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- W4205398938 endingPage "488" @default.
- W4205398938 startingPage "488" @default.
- W4205398938 abstract "Understanding the mechanisms of resistance to therapy in human cancer cells has become a multifaceted limiting factor to achieving optimal cures in cancer patients. Besides genetic and epigenetic alterations, enhanced DNA damage repair activity, deregulation of cell death, overexpression of transmembrane transporters, and complex interactions within the tumor microenvironment, other mechanisms of cancer treatment resistance have been recently proposed. In this review, we will summarize the preclinical and clinical studies highlighting the critical role of the microbiome in the efficacy of cancer treatment, concerning mainly chemotherapy and immunotherapy with immune checkpoint inhibitors. In addition to involvement in drug metabolism and immune surveillance, the production of microbiota-derived metabolites might represent the link between gut/intratumoral bacteria and response to anticancer therapies. Importantly, an emerging trend of using microbiota modulation by probiotics and fecal microbiota transplantation (FMT) to overcome cancer treatment resistance will be also discussed." @default.
- W4205398938 created "2022-01-25" @default.
- W4205398938 creator A5009013764 @default.
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- W4205398938 creator A5031309175 @default.
- W4205398938 creator A5050740286 @default.
- W4205398938 creator A5052989773 @default.
- W4205398938 creator A5085950307 @default.
- W4205398938 date "2022-01-01" @default.
- W4205398938 modified "2023-10-01" @default.
- W4205398938 title "The Impact of the Microbiome on Resistance to Cancer Treatment with Chemotherapeutic Agents and Immunotherapy" @default.
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