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- W4205403561 endingPage "1759720X2110609" @default.
- W4205403561 startingPage "1759720X2110609" @default.
- W4205403561 abstract "The antifibrotic therapies nintedanib and pirfenidone were first approved by the United States for the treatment of idiopathic pulmonary fibrosis in 2014. In 2020, nintedanib received U.S. Food and Drug Administration (FDA) approval for the treatment of all progressive fibrosing interstitial lung disease (ILD). Given that a major cause of mortality and morbidity in the idiopathic inflammatory myopathies (IIM) is progressive interstitial lung disease and respiratory failure, antifibrotic therapies may be useful as adjuvant to traditional immunosuppression. However, randomized controlled trials of antifibrotic therapies in IIM are lacking. The purpose of this review is to (1) summarize the mechanism of action of nintedanib and pirfenidone in ILD with possible role in IIM-ILD, (2) review the clinical data supporting their use in interstitial lung disease in general, and more specifically in connective tissue disease associated ILD, and (3) discuss the evidence and remaining challenges for using antifibrotic therapies in IIM-ILD." @default.
- W4205403561 created "2022-01-26" @default.
- W4205403561 creator A5021312163 @default.
- W4205403561 creator A5068568381 @default.
- W4205403561 date "2021-01-01" @default.
- W4205403561 modified "2023-10-18" @default.
- W4205403561 title "Role of antifibrotics in the management of idiopathic inflammatory myopathy associated interstitial lung disease" @default.
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- W4205403561 doi "https://doi.org/10.1177/1759720x211060907" @default.
- W4205403561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34917177" @default.
- W4205403561 hasPublicationYear "2021" @default.
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