Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205412802> ?p ?o ?g. }
- W4205412802 endingPage "331" @default.
- W4205412802 startingPage "310" @default.
- W4205412802 abstract "Non-alcoholic fatty liver disease (NAFLD) has emerged as the most common liver disorder worldwide mainly attributed to the epidemic spread of obesity and type 2 diabetes mellitus. Although it is considered a benign disease, NAFLD can progress to non-alcoholic steatohepatitis, liver cirrhosis and hepatocellular carcinoma (HCC). Most data regarding the epidemiology of NAFLD-related HCC are derived from cohort and population studies and show that its incidence is increasing as well as it is likely to emerge as the leading indication for liver transplantation, especially in the Western World. Although cirrhosis constitutes the main risk factor for HCC development, in patients with NAFLD, HCC can arise in the absence of cirrhosis, indicating specific carcinogenic molecular pathways. Since NAFLD as an underlying liver disease for HCC is often underdiagnosed due to lack of sufficient surveillance in this population, NAFLD-HCC patients are at advanced HCC stage at the time of diagnosis making the management of those patients clinically challenging and affecting their prognostic outcomes. In this current review, we summarize the latest literature on the epidemiology, other than liver cirrhosis-pathogenesis, risk factors and prognosis of NAFLD-HCC patients. Finally, we emphasize the prevention of the development of NAFLD-associated HCC and we provide some insight into the open questions and issues regarding the appropriate surveillance policies for those patients." @default.
- W4205412802 created "2022-01-26" @default.
- W4205412802 creator A5009573825 @default.
- W4205412802 creator A5054224194 @default.
- W4205412802 creator A5065144824 @default.
- W4205412802 creator A5084195133 @default.
- W4205412802 date "2022-01-21" @default.
- W4205412802 modified "2023-10-14" @default.
- W4205412802 title "Non-alcoholic fatty liver disease and hepatocellular carcinoma: Clinical challenges of an intriguing link" @default.
- W4205412802 cites W1035050697 @default.
- W4205412802 cites W1258381707 @default.
- W4205412802 cites W1596325438 @default.
- W4205412802 cites W1776128289 @default.
- W4205412802 cites W1843277435 @default.
- W4205412802 cites W1862643070 @default.
- W4205412802 cites W1920952588 @default.
- W4205412802 cites W1965385210 @default.
- W4205412802 cites W1967365717 @default.
- W4205412802 cites W1977567991 @default.
- W4205412802 cites W1980520860 @default.
- W4205412802 cites W1990340926 @default.
- W4205412802 cites W1990804638 @default.
- W4205412802 cites W1996424780 @default.
- W4205412802 cites W1996857574 @default.
- W4205412802 cites W2002004237 @default.
- W4205412802 cites W2002034811 @default.
- W4205412802 cites W2010042995 @default.
- W4205412802 cites W2016884881 @default.
- W4205412802 cites W2022514002 @default.
- W4205412802 cites W2023725755 @default.
- W4205412802 cites W2029691295 @default.
- W4205412802 cites W2029776483 @default.
- W4205412802 cites W2030543630 @default.
- W4205412802 cites W2034845419 @default.
- W4205412802 cites W2048613643 @default.
- W4205412802 cites W2051277632 @default.
- W4205412802 cites W2060343419 @default.
- W4205412802 cites W2061552888 @default.
- W4205412802 cites W2064890337 @default.
- W4205412802 cites W2067681932 @default.
- W4205412802 cites W2071424677 @default.
- W4205412802 cites W2071494821 @default.
- W4205412802 cites W2076341209 @default.
- W4205412802 cites W2078226028 @default.
- W4205412802 cites W2079146692 @default.
- W4205412802 cites W2080998956 @default.
- W4205412802 cites W2082712471 @default.
- W4205412802 cites W2086066803 @default.
- W4205412802 cites W2086542332 @default.
- W4205412802 cites W2087556175 @default.
- W4205412802 cites W2088849513 @default.
- W4205412802 cites W2097723042 @default.
- W4205412802 cites W2098629785 @default.
- W4205412802 cites W2101390213 @default.
- W4205412802 cites W2116448477 @default.
- W4205412802 cites W2117454090 @default.
- W4205412802 cites W2117976042 @default.
- W4205412802 cites W2137257146 @default.
- W4205412802 cites W2140561096 @default.
- W4205412802 cites W2145954591 @default.
- W4205412802 cites W2153974854 @default.
- W4205412802 cites W2160068207 @default.
- W4205412802 cites W2160233887 @default.
- W4205412802 cites W2163403599 @default.
- W4205412802 cites W2165778365 @default.
- W4205412802 cites W2170005129 @default.
- W4205412802 cites W2179591645 @default.
- W4205412802 cites W2204688218 @default.
- W4205412802 cites W2213177040 @default.
- W4205412802 cites W2237544788 @default.
- W4205412802 cites W2277004004 @default.
- W4205412802 cites W2288273357 @default.
- W4205412802 cites W2289068089 @default.
- W4205412802 cites W2321179708 @default.
- W4205412802 cites W2410624307 @default.
- W4205412802 cites W2412122776 @default.
- W4205412802 cites W2464819350 @default.
- W4205412802 cites W2517154702 @default.
- W4205412802 cites W2518412951 @default.
- W4205412802 cites W2527829175 @default.
- W4205412802 cites W2530478196 @default.
- W4205412802 cites W2550679725 @default.
- W4205412802 cites W2592093096 @default.
- W4205412802 cites W2607631396 @default.
- W4205412802 cites W2613817387 @default.
- W4205412802 cites W2625856057 @default.
- W4205412802 cites W2631630923 @default.
- W4205412802 cites W2679248272 @default.
- W4205412802 cites W2734724639 @default.
- W4205412802 cites W2750707341 @default.
- W4205412802 cites W2750832778 @default.
- W4205412802 cites W2752504842 @default.
- W4205412802 cites W2759997926 @default.
- W4205412802 cites W2760612518 @default.
- W4205412802 cites W2768061433 @default.
- W4205412802 cites W2796067155 @default.
- W4205412802 cites W2796459453 @default.
- W4205412802 cites W2808368206 @default.