FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205432885> ?p ?o ?g. }

• W4205432885 abstract "Parkinson's disease is a neurodegenerative disease characterized by the formation of neuronal inclusions of α-synuclein in patient brains. As the disease progresses, toxic α-synuclein aggregates transmit throughout the nervous system. No effective disease-modifying therapy has been established, and preventing α-synuclein aggregation is thought to be one of the most promising approaches to ameliorate the disease. In this study, we performed a two-step screening using the thioflavin T assay and a cell-based assay to identify α-synuclein aggregation inhibitors. The first screening, thioflavin T assay, allowed the identification of 30 molecules, among a total of 1262 FDA-approved small compounds, which showed inhibitory effects on α-synuclein fibrilization. In the second screening, a cell-based aggregation assay, seven out of these 30 candidates were found to prevent α-synuclein aggregation without causing substantial toxicity. Of the seven final candidates, tannic acid was the most promising compound. The robustness of our screening method was validated by a primary neuronal cell model and a Caenorhabditis elegans model, which demonstrated the effect of tannic acid against α-synuclein aggregation. In conclusion, our two-step screening system is a powerful method for the identification of α-synuclein aggregation inhibitors, and tannic acid is a promising candidate as a disease-modifying drug for Parkinson's disease." @default.
• W4205432885 created "2022-01-25" @default.
• W4205432885 creator A5000566593 @default.
• W4205432885 creator A5006806613 @default.
• W4205432885 creator A5022600763 @default.
• W4205432885 creator A5044022978 @default.
• W4205432885 creator A5044390320 @default.
• W4205432885 creator A5046287648 @default.
• W4205432885 creator A5046413444 @default.
• W4205432885 creator A5063560154 @default.
• W4205432885 creator A5064494183 @default.
• W4205432885 creator A5074347848 @default.
• W4205432885 creator A5074587065 @default.
• W4205432885 creator A5075166643 @default.
• W4205432885 creator A5077036127 @default.
• W4205432885 creator A5077674711 @default.
• W4205432885 creator A5087774085 @default.
• W4205432885 creator A5090144113 @default.
• W4205432885 date "2022-01-10" @default.
• W4205432885 modified "2023-10-17" @default.
• W4205432885 title "Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson’s disease" @default.
• W4205432885 cites W1923763303 @default.
• W4205432885 cites W1975341845 @default.
• W4205432885 cites W1989913002 @default.
• W4205432885 cites W1993241304 @default.
• W4205432885 cites W2026717532 @default.
• W4205432885 cites W2031215649 @default.
• W4205432885 cites W2034075546 @default.
• W4205432885 cites W2058233568 @default.
• W4205432885 cites W2072427499 @default.
• W4205432885 cites W2117503265 @default.
• W4205432885 cites W2124800531 @default.
• W4205432885 cites W2148373528 @default.
• W4205432885 cites W2148937629 @default.
• W4205432885 cites W2151616152 @default.
• W4205432885 cites W2162771723 @default.
• W4205432885 cites W2168432448 @default.
• W4205432885 cites W2174239077 @default.
• W4205432885 cites W2319269644 @default.
• W4205432885 cites W2339242828 @default.
• W4205432885 cites W2571594992 @default.
• W4205432885 cites W2593526069 @default.
• W4205432885 cites W2753292637 @default.
• W4205432885 cites W2893729429 @default.
• W4205432885 cites W2901519529 @default.
• W4205432885 cites W2911646467 @default.
• W4205432885 cites W2939921565 @default.
• W4205432885 cites W2960458171 @default.
• W4205432885 cites W2965362584 @default.
• W4205432885 cites W2969300201 @default.
• W4205432885 cites W2994755795 @default.
• W4205432885 doi "https://doi.org/10.1038/s41598-021-04131-9" @default.
• W4205432885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35013421" @default.
• W4205432885 hasPublicationYear "2022" @default.
• W4205432885 type Work @default.
• W4205432885 citedByCount "11" @default.
• W4205432885 countsByYear W42054328852022 @default.
• W4205432885 countsByYear W42054328852023 @default.
• W4205432885 crossrefType "journal-article" @default.
• W4205432885 hasAuthorship W4205432885A5000566593 @default.
• W4205432885 hasAuthorship W4205432885A5006806613 @default.
• W4205432885 hasAuthorship W4205432885A5022600763 @default.
• W4205432885 hasAuthorship W4205432885A5044022978 @default.
• W4205432885 hasAuthorship W4205432885A5044390320 @default.
• W4205432885 hasAuthorship W4205432885A5046287648 @default.
• W4205432885 hasAuthorship W4205432885A5046413444 @default.
• W4205432885 hasAuthorship W4205432885A5063560154 @default.
• W4205432885 hasAuthorship W4205432885A5064494183 @default.
• W4205432885 hasAuthorship W4205432885A5074347848 @default.
• W4205432885 hasAuthorship W4205432885A5074587065 @default.
• W4205432885 hasAuthorship W4205432885A5075166643 @default.
• W4205432885 hasAuthorship W4205432885A5077036127 @default.
• W4205432885 hasAuthorship W4205432885A5077674711 @default.
• W4205432885 hasAuthorship W4205432885A5087774085 @default.
• W4205432885 hasAuthorship W4205432885A5090144113 @default.
• W4205432885 hasBestOaLocation W42054328851 @default.
• W4205432885 hasConcept C104317684 @default.
• W4205432885 hasConcept C142724271 @default.
• W4205432885 hasConcept C178790620 @default.
• W4205432885 hasConcept C185592680 @default.
• W4205432885 hasConcept C2778896982 @default.
• W4205432885 hasConcept C2778944004 @default.
• W4205432885 hasConcept C2779134260 @default.
• W4205432885 hasConcept C2779734285 @default.
• W4205432885 hasConcept C2781393965 @default.
• W4205432885 hasConcept C502032728 @default.
• W4205432885 hasConcept C55493867 @default.
• W4205432885 hasConcept C71924100 @default.
• W4205432885 hasConcept C86803240 @default.
• W4205432885 hasConcept C98274493 @default.
• W4205432885 hasConceptScore W4205432885C104317684 @default.
• W4205432885 hasConceptScore W4205432885C142724271 @default.
• W4205432885 hasConceptScore W4205432885C178790620 @default.
• W4205432885 hasConceptScore W4205432885C185592680 @default.
• W4205432885 hasConceptScore W4205432885C2778896982 @default.
• W4205432885 hasConceptScore W4205432885C2778944004 @default.
• W4205432885 hasConceptScore W4205432885C2779134260 @default.
• W4205432885 hasConceptScore W4205432885C2779734285 @default.
• W4205432885 hasConceptScore W4205432885C2781393965 @default.
• W4205432885 hasConceptScore W4205432885C502032728 @default.

• next