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- W4205442747 abstract "Introduction Many nanoparticles have pharmacological and biochemical properties, including antioxidant and anti-inflammatory properties, which appear to be involved in anticarcinogenic and antimutagenic activities. In the recent study, nickel nanoparticles were green-synthesized using the Alhagi sparsifolia leaf aqueous extract. Material and methods The synthesized Ni nanoparticles were characterized by analytical techniques including SEM, UV-Vis., and FT-IR. The nanoparticles were formed in a spherical shape in the average size of 16.19 nm. Results In the antioxidant test, the IC50 of Ni nanoparticles and BHT against DPPH free radicals were 316 and 231 µg/mL, respectively. In the cellular and molecular part of the recent study, the treated cells with Ni nanoparticles were assessed by MTT assay for 48h about the cytotoxicity and anti-human breast cancer properties on normal (HUVEC) and breast cancer cell lines i.e. lobular carcinoma of breast (UACC-3133), inflammatory carcinoma of the breast (UACC-732), and metastatic carcinoma (MDA-MB-453). The viability of malignant breast cell line reduced dose-dependently in the presence of Ni nanoparticles. The IC50 of Ni nanoparticles were 477, 548, and 605 µg/mL against lobular carcinoma of breast (UACC-3133), inflammatory carcinoma of the breast (UACC-732), and metastatic carcinoma (MDA-MB-453) cell lines, respectively. Conclusions After clinical study, nickel nanoparticles containing Alhagi sparsifolia leaf aqueous extract may be used to formulate a new chemotherapeutic drug or supplement to treat the several types of human breast cancer. " @default.
- W4205442747 created "2022-01-25" @default.
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- W4205442747 date "2022-01-02" @default.
- W4205442747 modified "2023-10-14" @default.
- W4205442747 title "Anti-breast carcinoma effects of green synthesized nickel nanoparticles from Alhagi sparsifolia leaf aqueous extract: A pre-clinical trial study " @default.
- W4205442747 doi "https://doi.org/10.5114/aoms/145112" @default.
- W4205442747 hasPublicationYear "2022" @default.
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