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- W4205457746 abstract "Abstract Melatonin has been reported to affect intestinal function by targeting microbiome, morphological structure, barrier integrity and nutrient absorptive system. While the effect of melatonin on intestinal development in newborn infants is obscure, thus, this study firstly attempted to investigate the hypothesis that melatonin treatment improves intestinal development in sucking piglets. 14 healthy newborn piglets received 10 ml melatonin solution (1 mg/ml) or drinking water ( n = 7) for 21 days. The results showed that oral administration of melatonin increased liver relative weight ( p < 0.05) but failed to affect growth performance in sucking piglets ( p > 0.05). Immunostaining jejunal samples from melatonin group showed high expressions of nnos and claudin1, indicating that melatonin improved intestinal neural development and barrier integrity. Also, melatonin promoted intestinal absorptive function evidenced by the increased serum proline concentration in melatonin‐treated piglets compared with the control ( p < 0.05). Gut microbiota compositions were tested by 16S rDNA sequencing and the results showed that melatonin increased the relative abundance of Actinobacteria compared with the control ( p < 0.05) at the phylum level. However, Selenomonadales was markedly reduced compared with the control at the order level ( p < 0.05). Gut and faecal volatile fatty acids were tested to evaluate the microbiota metabolism, but no difference was noticed in volatile fatty acid concentrations ( p > 0.05). Melatonin improved intestinal development by affecting neural development, barrier integrity, nutrient absorption and microbiota in sucking piglets." @default.
- W4205457746 created "2022-01-25" @default.
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- W4205457746 date "2022-01-12" @default.
- W4205457746 modified "2023-10-06" @default.
- W4205457746 title "Effects of melatonin on intestinal function and bacterial compositions in sucking piglets" @default.
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- W4205457746 doi "https://doi.org/10.1111/jpn.13675" @default.
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