Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205493453> ?p ?o ?g. }
- W4205493453 endingPage "197" @default.
- W4205493453 startingPage "197" @default.
- W4205493453 abstract "The blood-brain barrier (BBB), which consists mainly of brain microvascular endothelial cells and astrocytes connected by tight junctions (TJs) and adhesion molecules (AMs), maintains the homeostatic balance between brain parenchyma and extracellular fluid. Accumulating evidence shows that BBB dysfunction is a common feature of neurodegenerative diseases, including stroke, traumatic brain injury, and Alzheimer's disease. Among the various pathological pathways of BBB dysfunction, reactive oxygen species (ROS) are known to play a key role in inducing BBB disruption mediated via TJ modification, AM induction, cytoskeletal reorganization, and matrix metalloproteinase activation. Thus, antioxidants have been suggested to exert beneficial effects on BBB dysfunction-associated brain diseases. In this review, we summarized the sources of ROS production in multiple cells that constitute or surround the BBB, such as BBB endothelial cells, astrocytes, microglia, and neutrophils. We also reviewed various pathological mechanisms by which BBB disruption is caused by ROS in these cells. Finally, we summarized the effects of various natural polyphenols on BBB dysfunction to suggest a therapeutic strategy for BBB disruption-related brain diseases." @default.
- W4205493453 created "2022-01-26" @default.
- W4205493453 creator A5003394582 @default.
- W4205493453 creator A5006429670 @default.
- W4205493453 creator A5041083866 @default.
- W4205493453 creator A5043855440 @default.
- W4205493453 creator A5062089122 @default.
- W4205493453 creator A5077656957 @default.
- W4205493453 date "2022-01-20" @default.
- W4205493453 modified "2023-10-14" @default.
- W4205493453 title "Effects of Natural Polyphenols on Oxidative Stress-Mediated Blood-Brain Barrier Dysfunction" @default.
- W4205493453 cites W1008398044 @default.
- W4205493453 cites W1536161802 @default.
- W4205493453 cites W1598564250 @default.
- W4205493453 cites W1619234695 @default.
- W4205493453 cites W1653299435 @default.
- W4205493453 cites W1699432502 @default.
- W4205493453 cites W1744354425 @default.
- W4205493453 cites W1847692201 @default.
- W4205493453 cites W1893412287 @default.
- W4205493453 cites W1896805280 @default.
- W4205493453 cites W1914622032 @default.
- W4205493453 cites W1955617899 @default.
- W4205493453 cites W1963645640 @default.
- W4205493453 cites W1965216303 @default.
- W4205493453 cites W1966653721 @default.
- W4205493453 cites W1966812653 @default.
- W4205493453 cites W1970881264 @default.
- W4205493453 cites W1970940868 @default.
- W4205493453 cites W1971050542 @default.
- W4205493453 cites W1971996726 @default.
- W4205493453 cites W1972489193 @default.
- W4205493453 cites W1974792405 @default.
- W4205493453 cites W1975412808 @default.
- W4205493453 cites W1976589295 @default.
- W4205493453 cites W1977253304 @default.
- W4205493453 cites W1977267175 @default.
- W4205493453 cites W1977940746 @default.
- W4205493453 cites W1979313341 @default.
- W4205493453 cites W1981258895 @default.
- W4205493453 cites W1986517451 @default.
- W4205493453 cites W1990887994 @default.
- W4205493453 cites W1992633183 @default.
- W4205493453 cites W1993998711 @default.
- W4205493453 cites W1994942139 @default.
- W4205493453 cites W1995984781 @default.
- W4205493453 cites W1997595168 @default.
- W4205493453 cites W1999713485 @default.
- W4205493453 cites W2001533810 @default.
- W4205493453 cites W2005675003 @default.
- W4205493453 cites W2005896958 @default.
- W4205493453 cites W2006496068 @default.
- W4205493453 cites W2006877449 @default.
- W4205493453 cites W2007636933 @default.
- W4205493453 cites W2010274527 @default.
- W4205493453 cites W2011564032 @default.
- W4205493453 cites W2012550810 @default.
- W4205493453 cites W2015085032 @default.
- W4205493453 cites W2015171564 @default.
- W4205493453 cites W2017300339 @default.
- W4205493453 cites W2020063866 @default.
- W4205493453 cites W2021273482 @default.
- W4205493453 cites W2023802645 @default.
- W4205493453 cites W2025960625 @default.
- W4205493453 cites W2033035679 @default.
- W4205493453 cites W2035569448 @default.
- W4205493453 cites W2041627221 @default.
- W4205493453 cites W2042487795 @default.
- W4205493453 cites W2045730256 @default.
- W4205493453 cites W2048801137 @default.
- W4205493453 cites W2051617804 @default.
- W4205493453 cites W2052322755 @default.
- W4205493453 cites W2052635425 @default.
- W4205493453 cites W2054720870 @default.
- W4205493453 cites W2057082641 @default.
- W4205493453 cites W2057745345 @default.
- W4205493453 cites W2058956065 @default.
- W4205493453 cites W2059299712 @default.
- W4205493453 cites W2064342286 @default.
- W4205493453 cites W2067108500 @default.
- W4205493453 cites W2067670322 @default.
- W4205493453 cites W2070872710 @default.
- W4205493453 cites W2070933064 @default.
- W4205493453 cites W2072862372 @default.
- W4205493453 cites W2073272315 @default.
- W4205493453 cites W2079916310 @default.
- W4205493453 cites W2080600302 @default.
- W4205493453 cites W2081653529 @default.
- W4205493453 cites W2084744910 @default.
- W4205493453 cites W2085128107 @default.
- W4205493453 cites W2085424855 @default.
- W4205493453 cites W2086443283 @default.
- W4205493453 cites W2086667809 @default.
- W4205493453 cites W2087243986 @default.
- W4205493453 cites W2089108509 @default.
- W4205493453 cites W2090857330 @default.
- W4205493453 cites W2091728196 @default.
- W4205493453 cites W2092852680 @default.