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• W4205502456 abstract "Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by reduced insulin sensitivity and dysfunction of β-cells. Although the increasing prevalence of diabetes worldwide is largely attributed to genetic predisposition or lifestyle factors (insufficient physical activity), and caloric intake. Environmental factors, exposure to xenobiotics and heavy metals have also been reported to be causative factors of T2DM. At this juncture, we, through our work unveil a plausible link between Pb2+ exposure and diabetes mellitus, and delineated a comprehensive understanding of the potential mechanisms of Pb2+-induced β-cells dysfunction. In our in vivo observations, we found that Pb2+ exposure strongly reduced glucose-stimulated insulin secretion and diminished functional pancreatic β-cell mass. Mechanistically, we found that Pb2+ downregulates intracellular cAMP level via hyper-activating Ca2+/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C and thereby reduces glucose-stimulated insulin secretion. Further, we report that Pb2+ inhibited mitochondrial adenosine triphosphate production and also identified Pb2+ as a negative regulator of β-cell proliferation via Ca2+/calmodulin-dependent protein kinase kinases-pAMPK-pRaptor axis. Together, our findings strongly reinforce Pb2+ to hijack the physiological role of calcium ions, by mimicking Ca2+ within pancreatic β-cell and thereby stands as a diabetogenic xenobiotic." @default.
• W4205502456 created "2022-01-26" @default.
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• W4205502456 date "2022-01-22" @default.
• W4205502456 modified "2023-10-18" @default.
• W4205502456 title "Molecular pathways dysregulated by Pb2+ exposure prompts pancreatic beta-cell dysfunction" @default.
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• W4205502456 doi "https://doi.org/10.1093/toxres/tfab121" @default.
• W4205502456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35237425" @default.
• W4205502456 hasPublicationYear "2022" @default.
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