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- W4205532761 endingPage "165" @default.
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- W4205532761 abstract "SARS-CoV-2, the coronavirus responsible for the current COVID-19 pandemic, encodes two proteases, 3CLpro and PLpro, two of the main antiviral research targets. Here we provide an overview of the structures and functions of 3CLpro and PLpro and examine strategies of structure-based drug designing and drug repurposing against these proteases. Rational structure-based drug design enables the generation of potent and target-specific antivirals. Drug repurposing offers an attractive prospect with an accelerated turnaround. Thus far, several protease inhibitors have been identified, and some candidates are undergoing trials that may well prove to be effective antivirals against SARS-CoV-2." @default.
- W4205532761 created "2022-01-26" @default.
- W4205532761 creator A5012344219 @default.
- W4205532761 creator A5041207856 @default.
- W4205532761 creator A5054454636 @default.
- W4205532761 date "2021-01-11" @default.
- W4205532761 modified "2023-09-26" @default.
- W4205532761 title "Structure-based inhibitor design and repurposing clinical drugs to target SARS-CoV-2 proteases" @default.
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- W4205532761 doi "https://doi.org/10.1042/bst20211180" @default.
- W4205532761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35015073" @default.
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