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Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205536259> ?p ?o ?g. }

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• W4205536259 abstract "The factor binding inducer of short transcripts-1 (FBI-1) is a POZ-domain Kruppel-like (POK) family of transcription factors and is known as a proto-oncogene or tumor suppressor in various carcinomas. However, the role of FBI-1 on epithelial-to-mesenchymal transition (EMT) and invasiveness in lung cancer remains unknown. Preliminarily, clinical data such as tissue microarray, Kaplan-Meier, and Oncomine were analyzed to confirm the correlation between lung cancer metastasis and FBI-1. To investigate the function of FBI-1 in EMT in lung cancer, EMT was measured in FBI-1-deficient or FBI-1-overexpressing cells. FBI-1 showed decreased expression in tumors metastasized to lymph nodes than in the primary tumor. In addition, it was also associated with improved survival rates of lung cancer patients. FBI-1 knockdown improved E-to-N-cadherin switching, migration, and invasion in A549 cells, similar to the initiation of EMT stimulated by transforming growth factor- β1 (TGF-β1). In contrast, overexpression of FBI-1 inhibited the transcription and activation of Smad2, thereby interfering with EMT, despite stimulation by TGF-β1. These results suggest that FBI-1 plays a negative role in EMT in lung cancer via the TGF-β1 signaling pathway, implying its use as a new potential therapeutic target and diagnostic indicator for early stage of lung cancer metastasis." @default.
• W4205536259 created "2022-01-25" @default.
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• W4205536259 date "2022-01-05" @default.
• W4205536259 modified "2023-10-16" @default.
• W4205536259 title "FBI‐1 inhibits epithelial‐to‐mesenchymal transition, migration, and invasion in lung adenocarcinoma A549 cells by downregulating transforming growth factor‐β1 signaling pathway" @default.
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• W4205536259 doi "https://doi.org/10.1002/jcb.30210" @default.
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