Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205540380> ?p ?o ?g. }
- W4205540380 endingPage "92" @default.
- W4205540380 startingPage "80" @default.
- W4205540380 abstract "Amyotrophic lateral sclerosis is a devastating neurodegenerative condition with few effective treatments. Current research is gathering momentum into the underlying pathology of this condition and how components of these pathological mechanisms affect individuals differently, leading to the broad manifestations encountered in clinical practice. We are moving away from considering this condition as merely an anterior horn cell disorder into a framework of a multisystem neurodegenerative condition in which early cortical hyperexcitability is key. The deposition of TAR DNA-binding protein 43 is also a relevant finding given the overlap with frontotemporal dysfunction. New techniques have been developed to provide a more accurate diagnosis, earlier in the disease course. This goes beyond the traditional nerve conduction studies and needle electromyography, to cortical excitability studies using transcranial magnetic stimulation, and the use of ultrasound. These ancillary tests are proposed for consideration of future diagnostic paradigms. As we learn more about this disease, future treatments need to ensure efficacy, safety, and a suitable target population to improve outcomes for these patients. In this time of active research into this condition, this paper highlights some of the areas of controversy to induce discussion surrounding these topics." @default.
- W4205540380 created "2022-01-25" @default.
- W4205540380 creator A5069734483 @default.
- W4205540380 creator A5087751182 @default.
- W4205540380 date "2020-07-13" @default.
- W4205540380 modified "2023-10-16" @default.
- W4205540380 title "Clinical Controversies in Amyotrophic Lateral Sclerosis" @default.
- W4205540380 cites W1215506979 @default.
- W4205540380 cites W135552506 @default.
- W4205540380 cites W1596759958 @default.
- W4205540380 cites W1690310058 @default.
- W4205540380 cites W1836565666 @default.
- W4205540380 cites W1963670372 @default.
- W4205540380 cites W1973993424 @default.
- W4205540380 cites W1983734876 @default.
- W4205540380 cites W1984200312 @default.
- W4205540380 cites W1991022478 @default.
- W4205540380 cites W1992045345 @default.
- W4205540380 cites W1994401109 @default.
- W4205540380 cites W1996576454 @default.
- W4205540380 cites W2003554693 @default.
- W4205540380 cites W2015037203 @default.
- W4205540380 cites W2020692948 @default.
- W4205540380 cites W2031132507 @default.
- W4205540380 cites W2037860056 @default.
- W4205540380 cites W2047541976 @default.
- W4205540380 cites W2055468364 @default.
- W4205540380 cites W2055538436 @default.
- W4205540380 cites W2059332922 @default.
- W4205540380 cites W2072177245 @default.
- W4205540380 cites W2073063121 @default.
- W4205540380 cites W2074020222 @default.
- W4205540380 cites W2076990754 @default.
- W4205540380 cites W2079844502 @default.
- W4205540380 cites W2088636845 @default.
- W4205540380 cites W2091712267 @default.
- W4205540380 cites W2098237643 @default.
- W4205540380 cites W2099310107 @default.
- W4205540380 cites W2101340322 @default.
- W4205540380 cites W2118968438 @default.
- W4205540380 cites W2128167427 @default.
- W4205540380 cites W2131461502 @default.
- W4205540380 cites W2136911505 @default.
- W4205540380 cites W2137169843 @default.
- W4205540380 cites W2137199534 @default.
- W4205540380 cites W2140248514 @default.
- W4205540380 cites W2142064395 @default.
- W4205540380 cites W2143695435 @default.
- W4205540380 cites W2148438777 @default.
- W4205540380 cites W2156236044 @default.
- W4205540380 cites W2158562257 @default.
- W4205540380 cites W2161938104 @default.
- W4205540380 cites W2165360324 @default.
- W4205540380 cites W2165829630 @default.
- W4205540380 cites W2169984218 @default.
- W4205540380 cites W2170769789 @default.
- W4205540380 cites W2273379033 @default.
- W4205540380 cites W2314689571 @default.
- W4205540380 cites W2337557761 @default.
- W4205540380 cites W2415773477 @default.
- W4205540380 cites W2460819002 @default.
- W4205540380 cites W2475222612 @default.
- W4205540380 cites W2520360089 @default.
- W4205540380 cites W2562565311 @default.
- W4205540380 cites W2565735485 @default.
- W4205540380 cites W2587274130 @default.
- W4205540380 cites W2591796793 @default.
- W4205540380 cites W2592442004 @default.
- W4205540380 cites W2593860967 @default.
- W4205540380 cites W2604965268 @default.
- W4205540380 cites W2608983137 @default.
- W4205540380 cites W2609198802 @default.
- W4205540380 cites W2614979396 @default.
- W4205540380 cites W2723715376 @default.
- W4205540380 cites W2735438407 @default.
- W4205540380 cites W2765457898 @default.
- W4205540380 cites W2768270394 @default.
- W4205540380 cites W2770703144 @default.
- W4205540380 cites W2773838930 @default.
- W4205540380 cites W2778547093 @default.
- W4205540380 cites W2790800342 @default.
- W4205540380 cites W2791173772 @default.
- W4205540380 cites W2794654744 @default.
- W4205540380 cites W2794716002 @default.
- W4205540380 cites W2801100899 @default.
- W4205540380 cites W2801564211 @default.
- W4205540380 cites W2884589591 @default.
- W4205540380 cites W2884915130 @default.
- W4205540380 cites W2901521475 @default.
- W4205540380 cites W2907108807 @default.
- W4205540380 cites W2912883663 @default.
- W4205540380 cites W2913609543 @default.
- W4205540380 cites W2920978396 @default.
- W4205540380 cites W2947054548 @default.
- W4205540380 cites W2948969964 @default.
- W4205540380 cites W2953194418 @default.
- W4205540380 cites W2959614930 @default.
- W4205540380 cites W2970644824 @default.