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• W4205547597 abstract "Subarachnoid hemorrhage (SAH) remains an important cause of mortality and long-term morbidity. This article uses a case-based approach to guide readers through the fundamental epidemiology and pathogenesis of SAH, the approach to diagnosis and management, the results of clinical trials and evidence to date, prognostic considerations, controversies, recent developments, and future directions in SAH.Historically, management of SAH focused on prevention and treatment of subsequent cerebral vasospasm, which was thought to be the primary cause of delayed cerebral ischemia. Clinical and translational studies over the past decade, including several therapeutic phase 3 randomized clinical trials, suggest that the pathophysiology of SAH-associated brain injury is multiphasic and multifactorial beyond large vessel cerebral vasospasm. The quest to reduce SAH-associated brain injury and improve outcomes is shifting away from large vessel cerebral vasospasm to a new paradigm targeting multiple brain injury mechanisms, including early brain injury, delayed cerebral ischemia, microcirculatory dysfunction, spreading cortical depolarization, inflammation, and the brain-body interaction in vascular brain injury with critical illness.Despite multiple negative randomized clinical trials in search of potential therapeutic agents ameliorating the downstream effects after SAH, the overall outcome of SAH has improved over recent decades, likely related to improvements in interventional options for ruptured cerebral aneurysms and in critical care management. Emerging clinical evidence also suggests potential harmful impact of historic empiric treatments for SAH-associated vasospasm, such as prophylactic induction of hypertension, hypervolemia, and hemodilution (triple H therapy).With decreasing mortality, long-term SAH survivorship and efforts to reduce chronic morbidity and to improve quality of life and patient-centered outcome are growing areas of unmet need. Despite existing guidelines, significant variabilities in local and regional practices and in scientific terminologies have historically limited advancement in SAH care and therapeutic development. Large global collaborative efforts developed harmonized SAH common data elements in 2019, and studies are under way to examine how existing variabilities in SAH care impact long-term SAH outcomes.Although the overall incidence and mortality of SAH is decreasing with advances in preventive and acute care, SAH remains a major cause of long-term morbidity in survivors. Significant variabilities in care settings and empiric treatment protocols and inconsistent scientific terminologies have limited advancement in patient care and therapeutic clinical studies. Large consensus efforts are under way to introduce clinical guidelines and common data elements to advance therapeutic approaches and improve patient outcome." @default.
• W4205547597 created "2022-01-25" @default.
• W4205547597 creator A5071706970 @default.
• W4205547597 date "2021-10-01" @default.
• W4205547597 modified "2023-10-12" @default.
• W4205547597 title "Subarachnoid Hemorrhage" @default.
• W4205547597 cites W1617537169 @default.
• W4205547597 cites W1624939398 @default.
• W4205547597 cites W1915219863 @default.
• W4205547597 cites W1966109927 @default.
• W4205547597 cites W1968226973 @default.
• W4205547597 cites W1969655988 @default.
• W4205547597 cites W1970647439 @default.
• W4205547597 cites W1972966055 @default.
• W4205547597 cites W1978857902 @default.
• W4205547597 cites W1984753589 @default.
• W4205547597 cites W1985930892 @default.
• W4205547597 cites W1989020267 @default.
• W4205547597 cites W1992575721 @default.
• W4205547597 cites W1994679985 @default.
• W4205547597 cites W1998024826 @default.
• W4205547597 cites W2000774826 @default.
• W4205547597 cites W2002638002 @default.
• W4205547597 cites W2012000361 @default.
• W4205547597 cites W2020527595 @default.
• W4205547597 cites W2024456239 @default.
• W4205547597 cites W2024945747 @default.
• W4205547597 cites W2027003025 @default.
• W4205547597 cites W2027822845 @default.
• W4205547597 cites W2030335004 @default.
• W4205547597 cites W2032134195 @default.
• W4205547597 cites W2037744261 @default.
• W4205547597 cites W2038022193 @default.
• W4205547597 cites W2038461636 @default.
• W4205547597 cites W2041172824 @default.
• W4205547597 cites W2044489109 @default.
• W4205547597 cites W2046442149 @default.
• W4205547597 cites W2046783992 @default.
• W4205547597 cites W2046926560 @default.
• W4205547597 cites W2049129828 @default.
• W4205547597 cites W2051837238 @default.
• W4205547597 cites W2051850514 @default.
• W4205547597 cites W2055090120 @default.
• W4205547597 cites W2057045896 @default.
• W4205547597 cites W2057173661 @default.
• W4205547597 cites W2059220913 @default.
• W4205547597 cites W2060752639 @default.
• W4205547597 cites W2061098130 @default.
• W4205547597 cites W2062079254 @default.
• W4205547597 cites W2063902766 @default.
• W4205547597 cites W2065094515 @default.
• W4205547597 cites W2069253288 @default.
• W4205547597 cites W2071876469 @default.
• W4205547597 cites W2074719184 @default.
• W4205547597 cites W2078080170 @default.
• W4205547597 cites W2082801080 @default.
• W4205547597 cites W2097128427 @default.
• W4205547597 cites W2098177993 @default.
• W4205547597 cites W2098798964 @default.
• W4205547597 cites W2102182787 @default.
• W4205547597 cites W2102869131 @default.
• W4205547597 cites W2103037096 @default.
• W4205547597 cites W2106692818 @default.
• W4205547597 cites W2107272669 @default.
• W4205547597 cites W2110471635 @default.
• W4205547597 cites W2111062482 @default.
• W4205547597 cites W2111708457 @default.
• W4205547597 cites W2113713760 @default.
• W4205547597 cites W2116291080 @default.
• W4205547597 cites W2116523744 @default.
• W4205547597 cites W2121685434 @default.
• W4205547597 cites W2124088483 @default.
• W4205547597 cites W2126003979 @default.
• W4205547597 cites W2131437690 @default.
• W4205547597 cites W2133016590 @default.
• W4205547597 cites W2136054150 @default.
• W4205547597 cites W2136265514 @default.
• W4205547597 cites W2137299577 @default.
• W4205547597 cites W2143671723 @default.
• W4205547597 cites W2144792598 @default.
• W4205547597 cites W2147462813 @default.
• W4205547597 cites W2155587611 @default.
• W4205547597 cites W2155759372 @default.
• W4205547597 cites W2157006832 @default.
• W4205547597 cites W2157219312 @default.
• W4205547597 cites W2157540829 @default.
• W4205547597 cites W2157872126 @default.
• W4205547597 cites W2158147889 @default.
• W4205547597 cites W2163508313 @default.
• W4205547597 cites W2166278425 @default.
• W4205547597 cites W2166435247 @default.
• W4205547597 cites W2168925567 @default.
• W4205547597 cites W2171390015 @default.
• W4205547597 cites W2185602086 @default.
• W4205547597 cites W2201277976 @default.
• W4205547597 cites W2219596193 @default.
• W4205547597 cites W2233303500 @default.
• W4205547597 cites W2306603485 @default.

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