FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205554352> ?p ?o ?g. }

• W4205554352 endingPage "3584" @default.
• W4205554352 startingPage "3569" @default.
• W4205554352 abstract "Mixed lineage kinase 3 (MLK3), a MAP3K member has been envisioned as a viable drug target in cancer, yet its detailed function and signaling is not fully elucidated. We identified that MLK3 tightly associates with an oncogene, PAK1. Mammalian PAK1 being a Ste20 (MAP4K) member, we tested whether it is an upstream regulator of MLK3. In contrast to our hypothesis, MLK3 activated PAK1 kinase activity directly, as well as in the cells. Although, MLK3 can phosphorylate PAK1 on Ser133 and Ser204 sites, PAK1S133A mutant is constitutively active, whereas, PAK1S204A is not activated by MLK3. Stable overexpression of PAK1S204A in breast cancer cells, impedes migration, invasion, and NFĸB activity. In vivo breast cancer cell tumorigenesis is significantly reduced in tumors expressing PAK1S204A mutant. These results suggest that mammalian PAK1 does not act as a MAP4K and MLK3-induced direct activation of PAK1 plays a key role in breast cancer tumorigenesis." @default.
• W4205554352 created "2022-01-25" @default.
• W4205554352 creator A5038930717 @default.
• W4205554352 creator A5044411309 @default.
• W4205554352 creator A5046360981 @default.
• W4205554352 creator A5049497627 @default.
• W4205554352 creator A5059546399 @default.
• W4205554352 creator A5061500801 @default.
• W4205554352 creator A5079175978 @default.
• W4205554352 creator A5081839578 @default.
• W4205554352 creator A5089191106 @default.
• W4205554352 date "2019-01-21" @default.
• W4205554352 modified "2023-10-16" @default.
• W4205554352 title "Mixed lineage kinase 3 promotes breast tumorigenesis via phosphorylation and activation of p21-activated kinase 1" @default.
• W4205554352 cites W1485140225 @default.
• W4205554352 cites W1539290896 @default.
• W4205554352 cites W1918275087 @default.
• W4205554352 cites W1964579181 @default.
• W4205554352 cites W1979400580 @default.
• W4205554352 cites W1980516263 @default.
• W4205554352 cites W1987134040 @default.
• W4205554352 cites W1998199805 @default.
• W4205554352 cites W1999826370 @default.
• W4205554352 cites W2009461629 @default.
• W4205554352 cites W2009906545 @default.
• W4205554352 cites W2016977803 @default.
• W4205554352 cites W2020466484 @default.
• W4205554352 cites W2027005796 @default.
• W4205554352 cites W2035394056 @default.
• W4205554352 cites W2037312364 @default.
• W4205554352 cites W2040567131 @default.
• W4205554352 cites W2050563501 @default.
• W4205554352 cites W2054353869 @default.
• W4205554352 cites W2054481493 @default.
• W4205554352 cites W2070190928 @default.
• W4205554352 cites W2080421196 @default.
• W4205554352 cites W2092529209 @default.
• W4205554352 cites W2094458603 @default.
• W4205554352 cites W2098301815 @default.
• W4205554352 cites W2102787965 @default.
• W4205554352 cites W2104453682 @default.
• W4205554352 cites W2109309944 @default.
• W4205554352 cites W2114136380 @default.
• W4205554352 cites W2114207292 @default.
• W4205554352 cites W2125708696 @default.
• W4205554352 cites W2126376309 @default.
• W4205554352 cites W2131564236 @default.
• W4205554352 cites W2132847489 @default.
• W4205554352 cites W2136499331 @default.
• W4205554352 cites W2150866920 @default.
• W4205554352 cites W2155201844 @default.
• W4205554352 cites W2170564629 @default.
• W4205554352 cites W2274038956 @default.
• W4205554352 cites W2284592103 @default.
• W4205554352 cites W2514674691 @default.
• W4205554352 cites W2613083354 @default.
• W4205554352 cites W2621792783 @default.
• W4205554352 cites W2766710027 @default.
• W4205554352 cites W2790805946 @default.
• W4205554352 cites W4233451333 @default.
• W4205554352 doi "https://doi.org/10.1038/s41388-019-0690-0" @default.
• W4205554352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30664689" @default.
• W4205554352 hasPublicationYear "2019" @default.
• W4205554352 type Work @default.
• W4205554352 citedByCount "11" @default.
• W4205554352 countsByYear W42055543522019 @default.
• W4205554352 countsByYear W42055543522020 @default.
• W4205554352 countsByYear W42055543522021 @default.
• W4205554352 countsByYear W42055543522022 @default.
• W4205554352 countsByYear W42055543522023 @default.
• W4205554352 crossrefType "journal-article" @default.
• W4205554352 hasAuthorship W4205554352A5038930717 @default.
• W4205554352 hasAuthorship W4205554352A5044411309 @default.
• W4205554352 hasAuthorship W4205554352A5046360981 @default.
• W4205554352 hasAuthorship W4205554352A5049497627 @default.
• W4205554352 hasAuthorship W4205554352A5059546399 @default.
• W4205554352 hasAuthorship W4205554352A5061500801 @default.
• W4205554352 hasAuthorship W4205554352A5079175978 @default.
• W4205554352 hasAuthorship W4205554352A5081839578 @default.
• W4205554352 hasAuthorship W4205554352A5089191106 @default.
• W4205554352 hasBestOaLocation W42055543522 @default.
• W4205554352 hasConcept C121608353 @default.
• W4205554352 hasConcept C137361374 @default.
• W4205554352 hasConcept C184235292 @default.
• W4205554352 hasConcept C24901178 @default.
• W4205554352 hasConcept C2781018059 @default.
• W4205554352 hasConcept C29537977 @default.
• W4205554352 hasConcept C502942594 @default.
• W4205554352 hasConcept C51853150 @default.
• W4205554352 hasConcept C54355233 @default.
• W4205554352 hasConcept C555283112 @default.
• W4205554352 hasConcept C86803240 @default.
• W4205554352 hasConcept C95444343 @default.
• W4205554352 hasConcept C97029542 @default.
• W4205554352 hasConceptScore W4205554352C121608353 @default.
• W4205554352 hasConceptScore W4205554352C137361374 @default.
• W4205554352 hasConceptScore W4205554352C184235292 @default.
• W4205554352 hasConceptScore W4205554352C24901178 @default.

• next