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- W4205560642 abstract "Abstract Bone metastases occur in patients with advanced-stage prostate cancer (PCa). The cell-cell interaction between PCa and the bone microenvironment forms a vicious cycle that modulates the bone microenvironment, increases bone deformities, and drives tumor growth in the bone. However, the molecular mechanisms of PCa-mediated modulation of the bone microenvironment are complex and remain poorly defined. Here, we evaluated growth differentiation factor-15 (GDF15) function using in vivo preclinical PCa-bone metastasis mouse models and an in vitro bone cell coculture system. Our results suggest that PCa-secreted GDF15 promotes bone metastases and induces bone microarchitectural alterations in a preclinical xenograft model. Mechanistic studies revealed that GDF15 increases osteoblast function and facilitates the growth of PCa in bone by activating osteoclastogenesis through osteoblastic production of CCL2 and RANKL and recruitment of osteomacs. Altogether, our findings demonstrate the critical role of GDF15 in the modulation of the bone microenvironment and subsequent development of PCa bone metastasis." @default.
- W4205560642 created "2022-01-25" @default.
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- W4205560642 date "2022-01-20" @default.
- W4205560642 modified "2023-10-16" @default.
- W4205560642 title "GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation" @default.
- W4205560642 cites W1507364611 @default.
- W4205560642 cites W1802397357 @default.
- W4205560642 cites W1864767937 @default.
- W4205560642 cites W1929863302 @default.
- W4205560642 cites W1960895270 @default.
- W4205560642 cites W1969959437 @default.
- W4205560642 cites W1970345836 @default.
- W4205560642 cites W1975577875 @default.
- W4205560642 cites W1975913194 @default.
- W4205560642 cites W1978073210 @default.
- W4205560642 cites W1979644682 @default.
- W4205560642 cites W1985058596 @default.
- W4205560642 cites W1988019879 @default.
- W4205560642 cites W1995156024 @default.
- W4205560642 cites W1998246535 @default.
- W4205560642 cites W1998254907 @default.
- W4205560642 cites W2016473084 @default.
- W4205560642 cites W2020641663 @default.
- W4205560642 cites W2026290208 @default.
- W4205560642 cites W2030908134 @default.
- W4205560642 cites W2031984295 @default.
- W4205560642 cites W2042811466 @default.
- W4205560642 cites W2048988434 @default.
- W4205560642 cites W2050309608 @default.
- W4205560642 cites W2051651031 @default.
- W4205560642 cites W2053042661 @default.
- W4205560642 cites W2060700125 @default.
- W4205560642 cites W2066749771 @default.
- W4205560642 cites W2072276134 @default.
- W4205560642 cites W2073982748 @default.
- W4205560642 cites W2083319499 @default.
- W4205560642 cites W2089903699 @default.
- W4205560642 cites W2090754742 @default.
- W4205560642 cites W2092273695 @default.
- W4205560642 cites W2097767628 @default.
- W4205560642 cites W2098868165 @default.
- W4205560642 cites W2108281583 @default.
- W4205560642 cites W2109525494 @default.
- W4205560642 cites W2109560931 @default.
- W4205560642 cites W2114050989 @default.
- W4205560642 cites W2116239490 @default.
- W4205560642 cites W2121299956 @default.
- W4205560642 cites W2128629090 @default.
- W4205560642 cites W2134975411 @default.
- W4205560642 cites W2138548105 @default.
- W4205560642 cites W2140727532 @default.
- W4205560642 cites W2145269260 @default.
- W4205560642 cites W2153628853 @default.
- W4205560642 cites W2166030187 @default.
- W4205560642 cites W2171338952 @default.
- W4205560642 cites W2307452902 @default.
- W4205560642 cites W2416479825 @default.
- W4205560642 cites W2495991482 @default.
- W4205560642 cites W2599351829 @default.
- W4205560642 cites W2599538813 @default.
- W4205560642 cites W2746853643 @default.
- W4205560642 cites W2748135921 @default.
- W4205560642 cites W2750180661 @default.
- W4205560642 cites W2759628183 @default.
- W4205560642 cites W2767646448 @default.
- W4205560642 cites W2787144751 @default.
- W4205560642 cites W2787956080 @default.
- W4205560642 cites W2801347649 @default.
- W4205560642 cites W2806481255 @default.
- W4205560642 cites W2907221685 @default.
- W4205560642 cites W2911188335 @default.
- W4205560642 cites W2912326250 @default.
- W4205560642 cites W2919595093 @default.
- W4205560642 cites W2923797470 @default.
- W4205560642 cites W2949310347 @default.
- W4205560642 cites W2955994816 @default.
- W4205560642 cites W2976906446 @default.
- W4205560642 cites W2986485896 @default.
- W4205560642 cites W3009560356 @default.
- W4205560642 cites W3080667847 @default.
- W4205560642 cites W3098851521 @default.
- W4205560642 doi "https://doi.org/10.1038/s41413-021-00178-6" @default.
- W4205560642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35058441" @default.
- W4205560642 hasPublicationYear "2022" @default.
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