Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205562189> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4205562189 abstract "Background: Interstitial lung disease in systemic sclerosis (SSc-ILD) is one of the most severe complications of systemic sclerosis (SSc) and is the main cause of mortality. In this study, we aimed to explore the key genes in SSc-ILD and analyze the relationship between key genes and immune cell infiltration as well as the key genes relevant to the hallmarks of cancer. Methods: Weighted gene co-expression network analysis (WGCNA) algorithm was implemented to explore hub genes in SSc-ILD samples from the Gene Expression Omnibus (GEO) database. Logistic regression analysis was performed to screen and verify the key gene related to SSc-ILD. CIBERSORT algorithms were utilized to analyze immune cell infiltration. Moreover, the correlation between the key genes and genes relevant to cancer was also evaluated. Furthermore, non-coding RNAs (ncRNAs) linking to PTGS2 were also explored. Results: In this study, we first performed WGCNA analysis for three GEO databases to find the potential hub genes in SSc-ILD. Subsequently, we determined PTGS2 was the key gene in SSC-ILD. Furthermore, in CIBERSORT analyses, PTGS2 were tightly correlated with immune cells such as regulatory T cells (Tregs) and was negatively correlated with CD20 expression. Moreover, PTGS2 was associated with tumor growth. Then, MALAT1, NEAT1, NORAD, XIST identified might be the most potential upstream lncRNAs, and LIMS1 and RANBP2 might be the two most potential upstream circRNAs. Conclusion: Collectively, our findings elucidated that ncRNAs-mediated downregulation of PTGS2, as a key gene in SSc-ILD, was positively related to the occurrence of SSc-ILD and abnormal immunocyte infiltration. It could be a promising factor for SSc-ILD progression to malignancy." @default.
- W4205562189 created "2022-01-26" @default.
- W4205562189 creator A5019566102 @default.
- W4205562189 creator A5049591354 @default.
- W4205562189 date "2022-01-13" @default.
- W4205562189 modified "2023-09-26" @default.
- W4205562189 title "The Downregulation of PTGS2 Mediated by ncRNAs is Tightly Correlated with Systemic Sclerosis-Interstitial Lung Disease" @default.
- W4205562189 cites W1515831988 @default.
- W4205562189 cites W1546712514 @default.
- W4205562189 cites W1567364560 @default.
- W4205562189 cites W1964703213 @default.
- W4205562189 cites W1974717741 @default.
- W4205562189 cites W1997074732 @default.
- W4205562189 cites W2013414651 @default.
- W4205562189 cites W2030516172 @default.
- W4205562189 cites W2056998032 @default.
- W4205562189 cites W2076796605 @default.
- W4205562189 cites W2077888205 @default.
- W4205562189 cites W2091579544 @default.
- W4205562189 cites W2091929727 @default.
- W4205562189 cites W2092260863 @default.
- W4205562189 cites W2098971028 @default.
- W4205562189 cites W2099344722 @default.
- W4205562189 cites W2103966606 @default.
- W4205562189 cites W2124495536 @default.
- W4205562189 cites W2146191069 @default.
- W4205562189 cites W2159731793 @default.
- W4205562189 cites W2498506084 @default.
- W4205562189 cites W2531669554 @default.
- W4205562189 cites W2549071917 @default.
- W4205562189 cites W2769504310 @default.
- W4205562189 cites W2790747514 @default.
- W4205562189 cites W2804710412 @default.
- W4205562189 cites W2915037198 @default.
- W4205562189 cites W2936745692 @default.
- W4205562189 cites W2944830642 @default.
- W4205562189 cites W3091233720 @default.
- W4205562189 cites W3131425476 @default.
- W4205562189 cites W3168277901 @default.
- W4205562189 cites W3185587603 @default.
- W4205562189 cites W4211001791 @default.
- W4205562189 doi "https://doi.org/10.3389/fgene.2021.795034" @default.
- W4205562189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35096012" @default.
- W4205562189 hasPublicationYear "2022" @default.
- W4205562189 type Work @default.
- W4205562189 citedByCount "1" @default.
- W4205562189 countsByYear W42055621892023 @default.
- W4205562189 crossrefType "journal-article" @default.
- W4205562189 hasAuthorship W4205562189A5019566102 @default.
- W4205562189 hasAuthorship W4205562189A5049591354 @default.
- W4205562189 hasBestOaLocation W42055621891 @default.
- W4205562189 hasConcept C104317684 @default.
- W4205562189 hasConcept C127561419 @default.
- W4205562189 hasConcept C203014093 @default.
- W4205562189 hasConcept C502942594 @default.
- W4205562189 hasConcept C54355233 @default.
- W4205562189 hasConcept C60644358 @default.
- W4205562189 hasConcept C70721500 @default.
- W4205562189 hasConcept C86803240 @default.
- W4205562189 hasConcept C8891405 @default.
- W4205562189 hasConceptScore W4205562189C104317684 @default.
- W4205562189 hasConceptScore W4205562189C127561419 @default.
- W4205562189 hasConceptScore W4205562189C203014093 @default.
- W4205562189 hasConceptScore W4205562189C502942594 @default.
- W4205562189 hasConceptScore W4205562189C54355233 @default.
- W4205562189 hasConceptScore W4205562189C60644358 @default.
- W4205562189 hasConceptScore W4205562189C70721500 @default.
- W4205562189 hasConceptScore W4205562189C86803240 @default.
- W4205562189 hasConceptScore W4205562189C8891405 @default.
- W4205562189 hasLocation W42055621891 @default.
- W4205562189 hasLocation W42055621892 @default.
- W4205562189 hasLocation W42055621893 @default.
- W4205562189 hasLocation W42055621894 @default.
- W4205562189 hasOpenAccess W4205562189 @default.
- W4205562189 hasPrimaryLocation W42055621891 @default.
- W4205562189 hasRelatedWork W2009966535 @default.
- W4205562189 hasRelatedWork W2019988726 @default.
- W4205562189 hasRelatedWork W2024344351 @default.
- W4205562189 hasRelatedWork W2082530227 @default.
- W4205562189 hasRelatedWork W2088063203 @default.
- W4205562189 hasRelatedWork W2171277769 @default.
- W4205562189 hasRelatedWork W2226563376 @default.
- W4205562189 hasRelatedWork W2539555867 @default.
- W4205562189 hasRelatedWork W2946009561 @default.
- W4205562189 hasRelatedWork W4309165329 @default.
- W4205562189 hasVolume "12" @default.
- W4205562189 isParatext "false" @default.
- W4205562189 isRetracted "false" @default.
- W4205562189 workType "article" @default.