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- W4205571522 abstract "In cortical pyramidal neurons, the axon initial segment (AIS) is pivotal in synaptic integration. It has been asserted that this is because there is a high density of Na(+) channels in the AIS. However, we found that action potential-associated Na(+) flux, as measured by high-speed fluorescence Na(+) imaging, was about threefold larger in the rat AIS than in the soma. Spike-evoked Na(+) flux in the AIS and the first node of Ranvier was similar and was eightfold lower in basal dendrites. At near-threshold voltages, persistent Na(+) conductance was almost entirely axonal. On a time scale of seconds, passive diffusion, and not pumping, was responsible for maintaining transmembrane Na(+) gradients in thin axons during high-frequency action potential firing. In computer simulations, these data were consistent with the known features of action potential generation in these neurons. PMID: 20543843 Funding information This work was supported by: NINDS NIH HHS, United States Grant ID: NS16295 NINDS NIH HHS, United States Grant ID: R56 NS016295 NINDS NIH HHS, United States Grant ID: R01 NS016295-25 NINDS NIH HHS, United States Grant ID: R01 NS016295" @default.
- W4205571522 created "2022-01-26" @default.
- W4205571522 creator A5021870639 @default.
- W4205571522 creator A5080645328 @default.
- W4205571522 date "2010-10-27" @default.
- W4205571522 modified "2023-09-28" @default.
- W4205571522 title "Faculty Opinions recommendation of Na+ imaging reveals little difference in action potential-evoked Na+ influx between axon and soma." @default.
- W4205571522 doi "https://doi.org/10.3410/f.5801957.5782058" @default.
- W4205571522 hasPublicationYear "2010" @default.
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