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• W4205601533 abstract "New paediatric acute lymphoblastic leukaemia (ALL) treatments have been developed and innovative products are in the pipeline. However, despite many active clinical trials, bridging bench science to clinical development to authorised medicines remains challenging. Research in first-line treatment continues to focus on multidrug chemotherapy with the potential addition of new targeted molecules being studied. Research in second- and third-line treatment represents a shift from cytotoxic intensification to an area of precision medicine through emergent innovative and immuno-oncology products. The collaborative research model in ALL involving different stakeholders should intensify to facilitate bench-to-bedside clinical translation for the benefit of patients." @default.
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• W4205601533 date "2022-05-01" @default.
• W4205601533 modified "2023-10-18" @default.
• W4205601533 title "The changing landscape of treatment options in childhood acute lymphoblastic leukaemia" @default.
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• W4205601533 doi "https://doi.org/10.1016/j.drudis.2022.01.002" @default.
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