Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205602844> ?p ?o ?g. }
- W4205602844 abstract "NRF2 is an important regulatory transcription factor involved in tumor immunity and tumorigenesis. In this study, we firstly identified that FKBP4/NR3C1 axis was a novel negative regulator of NRF2 in human breast cancer (BC) cells. The effect of FKBP4 appeared to be at protein level of NRF2 since it could not suppress the expression of NRF2 at mRNA level. Bioinformatics analysis and in vitro experiments further demonstrated that FKBP4 regulated NRF2 via regulating nuclear translocation of NR3C1. We then reported that naringenin, a flavonoid, widely distributed in citrus and tomato, could suppress autophagy and proliferation of BC cells through FKBP4/NR3C1/NRF2 signaling pathway in vitro and in vivo . Naringenin was also found to promote dendritic cell (DC) differentiation and maturation through FKBP4/NR3C1/NRF2 axis. Therefore, our study found that naringenin could induce inhibition of autophagy and cell proliferation in BC cells and enhance DC differentiation and maturation, at least in part, though regulation of FKBP4/NR3C1/NRF2 signaling pathway. Identification of FKBP4/NR3C1/NRF2 axis would provide insights for novel anti-tumor strategy against BC among tumor microenvironment." @default.
- W4205602844 created "2022-01-26" @default.
- W4205602844 creator A5007727798 @default.
- W4205602844 creator A5015137947 @default.
- W4205602844 creator A5018682457 @default.
- W4205602844 creator A5022022449 @default.
- W4205602844 creator A5022135589 @default.
- W4205602844 creator A5039227471 @default.
- W4205602844 creator A5039972688 @default.
- W4205602844 creator A5040724695 @default.
- W4205602844 creator A5042977387 @default.
- W4205602844 creator A5059010780 @default.
- W4205602844 creator A5067331026 @default.
- W4205602844 creator A5075284628 @default.
- W4205602844 creator A5082446769 @default.
- W4205602844 creator A5086721744 @default.
- W4205602844 date "2022-01-11" @default.
- W4205602844 modified "2023-09-30" @default.
- W4205602844 title "Naringenin Regulates FKBP4/NR3C1/NRF2 Axis in Autophagy and Proliferation of Breast Cancer and Differentiation and Maturation of Dendritic Cell" @default.
- W4205602844 cites W1565139562 @default.
- W4205602844 cites W1986875278 @default.
- W4205602844 cites W2011944525 @default.
- W4205602844 cites W2057187391 @default.
- W4205602844 cites W2063914959 @default.
- W4205602844 cites W2072393712 @default.
- W4205602844 cites W2075363163 @default.
- W4205602844 cites W2080292146 @default.
- W4205602844 cites W2080961843 @default.
- W4205602844 cites W2100097928 @default.
- W4205602844 cites W2111554856 @default.
- W4205602844 cites W2113754791 @default.
- W4205602844 cites W2116102471 @default.
- W4205602844 cites W2125583308 @default.
- W4205602844 cites W2158424998 @default.
- W4205602844 cites W2238888716 @default.
- W4205602844 cites W2295795004 @default.
- W4205602844 cites W2323644713 @default.
- W4205602844 cites W2336310263 @default.
- W4205602844 cites W2406251568 @default.
- W4205602844 cites W2520059130 @default.
- W4205602844 cites W2574924315 @default.
- W4205602844 cites W2583321150 @default.
- W4205602844 cites W2604819250 @default.
- W4205602844 cites W2605179369 @default.
- W4205602844 cites W2755119609 @default.
- W4205602844 cites W2765224588 @default.
- W4205602844 cites W2788528841 @default.
- W4205602844 cites W2794855596 @default.
- W4205602844 cites W2801988573 @default.
- W4205602844 cites W2883138700 @default.
- W4205602844 cites W2888230285 @default.
- W4205602844 cites W2900569176 @default.
- W4205602844 cites W2908708255 @default.
- W4205602844 cites W2936435806 @default.
- W4205602844 cites W2937441321 @default.
- W4205602844 cites W2965787757 @default.
- W4205602844 cites W2971049957 @default.
- W4205602844 cites W2998289897 @default.
- W4205602844 cites W3000513632 @default.
- W4205602844 cites W3003857694 @default.
- W4205602844 cites W3007012676 @default.
- W4205602844 cites W3014035083 @default.
- W4205602844 cites W3035950898 @default.
- W4205602844 cites W3037387411 @default.
- W4205602844 cites W3049605820 @default.
- W4205602844 cites W3095246951 @default.
- W4205602844 cites W3101711825 @default.
- W4205602844 cites W3107816418 @default.
- W4205602844 cites W3110258185 @default.
- W4205602844 cites W3112558224 @default.
- W4205602844 cites W3113269386 @default.
- W4205602844 cites W3116246032 @default.
- W4205602844 cites W3118356443 @default.
- W4205602844 cites W3119935843 @default.
- W4205602844 cites W3129510414 @default.
- W4205602844 cites W3129623592 @default.
- W4205602844 cites W3133117906 @default.
- W4205602844 cites W3164344078 @default.
- W4205602844 cites W3169464055 @default.
- W4205602844 cites W3173386337 @default.
- W4205602844 cites W3194278424 @default.
- W4205602844 cites W3201513519 @default.
- W4205602844 cites W904177710 @default.
- W4205602844 doi "https://doi.org/10.3389/fimmu.2021.745111" @default.
- W4205602844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35087512" @default.
- W4205602844 hasPublicationYear "2022" @default.
- W4205602844 type Work @default.
- W4205602844 citedByCount "9" @default.
- W4205602844 countsByYear W42056028442022 @default.
- W4205602844 countsByYear W42056028442023 @default.
- W4205602844 crossrefType "journal-article" @default.
- W4205602844 hasAuthorship W4205602844A5007727798 @default.
- W4205602844 hasAuthorship W4205602844A5015137947 @default.
- W4205602844 hasAuthorship W4205602844A5018682457 @default.
- W4205602844 hasAuthorship W4205602844A5022022449 @default.
- W4205602844 hasAuthorship W4205602844A5022135589 @default.
- W4205602844 hasAuthorship W4205602844A5039227471 @default.
- W4205602844 hasAuthorship W4205602844A5039972688 @default.
- W4205602844 hasAuthorship W4205602844A5040724695 @default.
- W4205602844 hasAuthorship W4205602844A5042977387 @default.