FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205606962> ?p ?o ?g. }

• W4205606962 abstract "Yellow mutant rainbow trout (YR), an economically important aquaculture species, is popular among consumers due to its excellent meat quality and attractive appearance. Skin color is a key economic trait for YR, but little is known about the molecular mechanism of skin color development. In this study, YR skin transcriptomes were analyzed to explore temporal expression patterns of pigmentation-related genes in three different stages of skin color development. In total, 16,590, 16,682, and 5619 genes were differentially expressed between fish at 1 day post-hatching (YR1d) and YR45d, YR1d and YR90d, and YR45d and YR90d. Numerous differentially expressed genes (DEGs) associated with pigmentation were identified, and almost all of them involved in pteridine and carotenoid synthesis were significantly upregulated in YR45d and YR90d compared to YR1d, including GCH1, PTS, QDPR, CSFIR1, SLC2A11, SCARB1, DGAT2, PNPLA2, APOD, and BCO2. Interestingly, many DEGs enriched in melanin synthesis pathways were also significantly upregulated, including melanogenesis (MITF, MC1R, SLC45A2, OCA2, and GPR143), tyrosine metabolism (TYR, TYRP1, and DCT), and MAPK signaling (KITA) pathways. Using short time-series expression miner, we identified eight differential gene expression pattern profiles, and DEGs in profile 7 were associated with skin pigmentation. Protein-protein interaction network analysis showed that two modules were related to xanthophores and melanophores. In addition, 1,812,329 simple sequence repeats and 2,011,334 single-nucleotide polymorphisms were discovered. The results enhance our understanding of the molecular mechanism underlying skin pigmentation in YR, and could accelerate the molecular breeding of fish species with valuable skin color traits and will likely be highly informative for developing new therapeutic approaches to treat pigmentation disorders and melanoma." @default.
• W4205606962 created "2022-01-26" @default.
• W4205606962 creator A5004003643 @default.
• W4205606962 creator A5014032287 @default.
• W4205606962 creator A5021162259 @default.
• W4205606962 creator A5027355538 @default.
• W4205606962 creator A5091161457 @default.
• W4205606962 date "2022-01-07" @default.
• W4205606962 modified "2023-10-17" @default.
• W4205606962 title "Analysis of yellow mutant rainbow trout transcriptomes at different developmental stages reveals dynamic regulation of skin pigmentation genes" @default.
• W4205606962 cites W1523735757 @default.
• W4205606962 cites W1568479515 @default.
• W4205606962 cites W1919257374 @default.
• W4205606962 cites W1965441780 @default.
• W4205606962 cites W1990139375 @default.
• W4205606962 cites W1995392225 @default.
• W4205606962 cites W1996664737 @default.
• W4205606962 cites W1999574084 @default.
• W4205606962 cites W2004767010 @default.
• W4205606962 cites W2007688165 @default.
• W4205606962 cites W2012619286 @default.
• W4205606962 cites W2019894619 @default.
• W4205606962 cites W2026647084 @default.
• W4205606962 cites W2033254013 @default.
• W4205606962 cites W2035341583 @default.
• W4205606962 cites W2043584813 @default.
• W4205606962 cites W2067857309 @default.
• W4205606962 cites W2069272954 @default.
• W4205606962 cites W2070314600 @default.
• W4205606962 cites W2072253833 @default.
• W4205606962 cites W2077892522 @default.
• W4205606962 cites W2078148759 @default.
• W4205606962 cites W2089117727 @default.
• W4205606962 cites W2092923458 @default.
• W4205606962 cites W2100184629 @default.
• W4205606962 cites W2102278945 @default.
• W4205606962 cites W2117450603 @default.
• W4205606962 cites W2133619623 @default.
• W4205606962 cites W2134160835 @default.
• W4205606962 cites W2148442536 @default.
• W4205606962 cites W2149098514 @default.
• W4205606962 cites W2179438025 @default.
• W4205606962 cites W2328767622 @default.
• W4205606962 cites W2513000638 @default.
• W4205606962 cites W2537951649 @default.
• W4205606962 cites W2610547935 @default.
• W4205606962 cites W2727469432 @default.
• W4205606962 cites W2767955636 @default.
• W4205606962 cites W2792512244 @default.
• W4205606962 cites W2796383848 @default.
• W4205606962 cites W2796956188 @default.
• W4205606962 cites W2801280700 @default.
• W4205606962 cites W2885052823 @default.
• W4205606962 cites W2888467903 @default.
• W4205606962 cites W2889622461 @default.
• W4205606962 cites W2911328426 @default.
• W4205606962 cites W2942040299 @default.
• W4205606962 cites W2951912016 @default.
• W4205606962 cites W2955647443 @default.
• W4205606962 cites W2980826742 @default.
• W4205606962 cites W2984362923 @default.
• W4205606962 cites W2992486743 @default.
• W4205606962 cites W2997642271 @default.
• W4205606962 cites W2998815211 @default.
• W4205606962 cites W3002803640 @default.
• W4205606962 cites W3003849327 @default.
• W4205606962 cites W3013256333 @default.
• W4205606962 cites W3041711062 @default.
• W4205606962 cites W3109146736 @default.
• W4205606962 cites W3121430125 @default.
• W4205606962 cites W3134041005 @default.
• W4205606962 cites W3164762952 @default.
• W4205606962 cites W802784551 @default.
• W4205606962 doi "https://doi.org/10.1038/s41598-021-04255-y" @default.
• W4205606962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34997156" @default.
• W4205606962 hasPublicationYear "2022" @default.
• W4205606962 type Work @default.
• W4205606962 citedByCount "12" @default.
• W4205606962 countsByYear W42056069622022 @default.
• W4205606962 countsByYear W42056069622023 @default.
• W4205606962 crossrefType "journal-article" @default.
• W4205606962 hasAuthorship W4205606962A5004003643 @default.
• W4205606962 hasAuthorship W4205606962A5014032287 @default.
• W4205606962 hasAuthorship W4205606962A5021162259 @default.
• W4205606962 hasAuthorship W4205606962A5027355538 @default.
• W4205606962 hasAuthorship W4205606962A5091161457 @default.
• W4205606962 hasBestOaLocation W42056069621 @default.
• W4205606962 hasConcept C104317684 @default.
• W4205606962 hasConcept C107538193 @default.
• W4205606962 hasConcept C143065580 @default.
• W4205606962 hasConcept C150194340 @default.
• W4205606962 hasConcept C154945302 @default.
• W4205606962 hasConcept C162317418 @default.
• W4205606962 hasConcept C177504595 @default.
• W4205606962 hasConcept C2779363728 @default.
• W4205606962 hasConcept C2909208804 @default.
• W4205606962 hasConcept C2994167347 @default.
• W4205606962 hasConcept C3019497199 @default.
• W4205606962 hasConcept C41008148 @default.
• W4205606962 hasConcept C505870484 @default.

• next