Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205638465> ?p ?o ?g. }
- W4205638465 abstract "Alu (B1 in rodents) hypomethylation, commonly found in diabetes mellitus patients, increases DNA damage and, consequently, delays the healing process. Alu siRNA increases Alu methylation, reduces DNA damage, and promotes cell proliferation. Aim: To explore whether B1 siRNA treatment restores B1 hypomethylation, resulting in a reduction in DNA damage and acceleration of the healing process in diabetic rat wounds. Methods: We generated splinted-excisional wounds in a streptozotocin (STZ)-induced type I diabetic rat model and treated the wounds with B1 siRNA/Ca-P nanoparticles to generate de novo DNA methylation in B1 intersperse elements. After treatment, we investigated B1 methylation levels, wound closure rate, wound histopathological structure, and DNA damage markers in diabetic wounds compared to nondiabetic wounds. Results: We reported that STZ-induced diabetic rat wounds exhibited B1 hypomethylation, wound repair defects, anatomical feature defects, and greater DNA damage compared to normal rats. We also determined that B1 siRNA treatment by Ca-P nanoparticle delivery restored a decrease in B1 methylation levels, remedied delayed wound healing, and improved the histological appearance of the wounds by reducing DNA damage. Conclusion: B1 hypomethylation is inducible in an STZ-induced type I diabetes rat model. Restoration of B1 hypomethylation using B1 siRNA leads to increased genome stability and improved wound repair in diabetes. Thus, B1 siRNA intervention may be a promising strategy for reprogramming DNA methylation to treat or prevent DNA damage-related diseases." @default.
- W4205638465 created "2022-01-25" @default.
- W4205638465 creator A5003962079 @default.
- W4205638465 creator A5020848195 @default.
- W4205638465 creator A5021302353 @default.
- W4205638465 creator A5031684327 @default.
- W4205638465 creator A5059415018 @default.
- W4205638465 creator A5070902598 @default.
- W4205638465 creator A5082830311 @default.
- W4205638465 creator A5088464169 @default.
- W4205638465 date "2022-01-19" @default.
- W4205638465 modified "2023-10-17" @default.
- W4205638465 title "B1 siRNA Increases de novo DNA Methylation of B1 Elements and Promotes Wound Healing in Diabetic Rats" @default.
- W4205638465 cites W1492946553 @default.
- W4205638465 cites W1500301819 @default.
- W4205638465 cites W1589742555 @default.
- W4205638465 cites W1967162280 @default.
- W4205638465 cites W1998731196 @default.
- W4205638465 cites W2009410829 @default.
- W4205638465 cites W2010798028 @default.
- W4205638465 cites W2014011582 @default.
- W4205638465 cites W2029005510 @default.
- W4205638465 cites W2037269568 @default.
- W4205638465 cites W2038510075 @default.
- W4205638465 cites W2039551908 @default.
- W4205638465 cites W2044874714 @default.
- W4205638465 cites W2081255427 @default.
- W4205638465 cites W2083510466 @default.
- W4205638465 cites W2096138645 @default.
- W4205638465 cites W2118977202 @default.
- W4205638465 cites W2119304571 @default.
- W4205638465 cites W2126525177 @default.
- W4205638465 cites W2129322966 @default.
- W4205638465 cites W2134965616 @default.
- W4205638465 cites W2137915568 @default.
- W4205638465 cites W2140204893 @default.
- W4205638465 cites W2145373200 @default.
- W4205638465 cites W2150708667 @default.
- W4205638465 cites W2153357138 @default.
- W4205638465 cites W2158231606 @default.
- W4205638465 cites W2163126627 @default.
- W4205638465 cites W2401288143 @default.
- W4205638465 cites W2560781586 @default.
- W4205638465 cites W2600560431 @default.
- W4205638465 cites W2606906244 @default.
- W4205638465 cites W2751717321 @default.
- W4205638465 cites W2782922662 @default.
- W4205638465 cites W2790277709 @default.
- W4205638465 cites W2896818937 @default.
- W4205638465 cites W2915171406 @default.
- W4205638465 cites W2922354437 @default.
- W4205638465 cites W2950785043 @default.
- W4205638465 cites W3036982723 @default.
- W4205638465 cites W3092252116 @default.
- W4205638465 cites W3133732579 @default.
- W4205638465 cites W3211005720 @default.
- W4205638465 cites W4241151929 @default.
- W4205638465 cites W63612215 @default.
- W4205638465 cites W2093083120 @default.
- W4205638465 doi "https://doi.org/10.3389/fcell.2021.802024" @default.
- W4205638465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35127718" @default.
- W4205638465 hasPublicationYear "2022" @default.
- W4205638465 type Work @default.
- W4205638465 citedByCount "2" @default.
- W4205638465 countsByYear W42056384652022 @default.
- W4205638465 countsByYear W42056384652023 @default.
- W4205638465 crossrefType "journal-article" @default.
- W4205638465 hasAuthorship W4205638465A5003962079 @default.
- W4205638465 hasAuthorship W4205638465A5020848195 @default.
- W4205638465 hasAuthorship W4205638465A5021302353 @default.
- W4205638465 hasAuthorship W4205638465A5031684327 @default.
- W4205638465 hasAuthorship W4205638465A5059415018 @default.
- W4205638465 hasAuthorship W4205638465A5070902598 @default.
- W4205638465 hasAuthorship W4205638465A5082830311 @default.
- W4205638465 hasAuthorship W4205638465A5088464169 @default.
- W4205638465 hasBestOaLocation W42056384651 @default.
- W4205638465 hasConcept C104317684 @default.
- W4205638465 hasConcept C134018914 @default.
- W4205638465 hasConcept C134935766 @default.
- W4205638465 hasConcept C143425029 @default.
- W4205638465 hasConcept C150194340 @default.
- W4205638465 hasConcept C153911025 @default.
- W4205638465 hasConcept C190727270 @default.
- W4205638465 hasConcept C203014093 @default.
- W4205638465 hasConcept C2779280383 @default.
- W4205638465 hasConcept C2780269544 @default.
- W4205638465 hasConcept C33288867 @default.
- W4205638465 hasConcept C502942594 @default.
- W4205638465 hasConcept C552990157 @default.
- W4205638465 hasConcept C55493867 @default.
- W4205638465 hasConcept C555293320 @default.
- W4205638465 hasConcept C71924100 @default.
- W4205638465 hasConcept C86803240 @default.
- W4205638465 hasConceptScore W4205638465C104317684 @default.
- W4205638465 hasConceptScore W4205638465C134018914 @default.
- W4205638465 hasConceptScore W4205638465C134935766 @default.
- W4205638465 hasConceptScore W4205638465C143425029 @default.
- W4205638465 hasConceptScore W4205638465C150194340 @default.
- W4205638465 hasConceptScore W4205638465C153911025 @default.
- W4205638465 hasConceptScore W4205638465C190727270 @default.