FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205645563> ?p ?o ?g. }

• W4205645563 abstract "Endothelium plays a fundamental role in the cardiovascular system, forming an interface between blood and adjacent tissues by regulating the vascular tone through the synthesis of nitric oxide, prostaglandins and other relaxing factors. Endothelial dysfunction is characterized by vasoconstriction, cell proliferation and shifting toward a proinflammatory and prothrombic state. In hypertension endothelial dysfunction may be involved in the initiation and development of vascular inflammation, vascular remodeling, and atherosclerosis and is independently associated with increased cardiovascular risk. Different conditions such as impaired vascular shear stress, inflammation and oxidative stress, activation of the renin angiotensin system have been described as important pathophysiological mechanisms involved in the development of endothelial dysfunction. The release of extracellular vesicles by neighboring cells in the vascular wall has emerged as an important regulator of endothelial function and with potential antihypertensive properties and beneficial effects by counteracting the hypertension mediated organ damage. Furthermore, macrovesicles are emerging as an innovative therapeutic approach for vascular protection, allowing the delivery of bioactive molecules, such as miRNA and drugs interacting with the renin angiotensin system. In this review we summarize the available evidence about the pathophysiological implications of endothelial dysfunction in cardiovascular diseases, focusing on hypertension and its sequelae, and the potential innovative therapeutic strategies targeting the endothelium with the aim to improve vascular function and remodeling." @default.
• W4205645563 created "2022-01-25" @default.
• W4205645563 creator A5020814480 @default.
• W4205645563 creator A5031769855 @default.
• W4205645563 creator A5054282642 @default.
• W4205645563 date "2022-01-20" @default.
• W4205645563 modified "2023-10-13" @default.
• W4205645563 title "Endothelial Dysfunction in Hypertension: Current Concepts and Clinical Implications" @default.
• W4205645563 cites W1562019099 @default.
• W4205645563 cites W1965691046 @default.
• W4205645563 cites W1966294883 @default.
• W4205645563 cites W1966971152 @default.
• W4205645563 cites W1971219120 @default.
• W4205645563 cites W1972436525 @default.
• W4205645563 cites W1975582897 @default.
• W4205645563 cites W1975781920 @default.
• W4205645563 cites W1981777743 @default.
• W4205645563 cites W1985578715 @default.
• W4205645563 cites W2003213503 @default.
• W4205645563 cites W2006898427 @default.
• W4205645563 cites W2009425158 @default.
• W4205645563 cites W2014346055 @default.
• W4205645563 cites W2018928665 @default.
• W4205645563 cites W2032171017 @default.
• W4205645563 cites W2032831426 @default.
• W4205645563 cites W2034426742 @default.
• W4205645563 cites W2037304767 @default.
• W4205645563 cites W2047107207 @default.
• W4205645563 cites W2053811269 @default.
• W4205645563 cites W2054177388 @default.
• W4205645563 cites W2055313665 @default.
• W4205645563 cites W2058767592 @default.
• W4205645563 cites W2061241639 @default.
• W4205645563 cites W2061595855 @default.
• W4205645563 cites W2069439360 @default.
• W4205645563 cites W2073859895 @default.
• W4205645563 cites W2074249358 @default.
• W4205645563 cites W2074499846 @default.
• W4205645563 cites W2084299658 @default.
• W4205645563 cites W2087754977 @default.
• W4205645563 cites W2106552550 @default.
• W4205645563 cites W2109074735 @default.
• W4205645563 cites W2111074998 @default.
• W4205645563 cites W2112443030 @default.
• W4205645563 cites W2114197087 @default.
• W4205645563 cites W2114369401 @default.
• W4205645563 cites W2116643762 @default.
• W4205645563 cites W2117748926 @default.
• W4205645563 cites W2120215319 @default.
• W4205645563 cites W2128651238 @default.
• W4205645563 cites W2131604815 @default.
• W4205645563 cites W2135265732 @default.
• W4205645563 cites W2139764595 @default.
• W4205645563 cites W2152399868 @default.
• W4205645563 cites W2152573476 @default.
• W4205645563 cites W2154663568 @default.
• W4205645563 cites W2161020445 @default.
• W4205645563 cites W2170273026 @default.
• W4205645563 cites W2181427902 @default.
• W4205645563 cites W2189340346 @default.
• W4205645563 cites W2228705256 @default.
• W4205645563 cites W2324841714 @default.
• W4205645563 cites W2330725315 @default.
• W4205645563 cites W2339774418 @default.
• W4205645563 cites W2377502162 @default.
• W4205645563 cites W2528037656 @default.
• W4205645563 cites W2561564221 @default.
• W4205645563 cites W2610817715 @default.
• W4205645563 cites W2726705340 @default.
• W4205645563 cites W2780378120 @default.
• W4205645563 cites W2793728426 @default.
• W4205645563 cites W2803038140 @default.
• W4205645563 cites W2962098235 @default.
• W4205645563 cites W2966654380 @default.
• W4205645563 cites W2978918943 @default.
• W4205645563 cites W2991072457 @default.
• W4205645563 cites W3003109697 @default.
• W4205645563 cites W3008065272 @default.
• W4205645563 cites W3015197361 @default.
• W4205645563 cites W3041110715 @default.
• W4205645563 cites W3093230136 @default.
• W4205645563 cites W3121389098 @default.
• W4205645563 cites W3165793489 @default.
• W4205645563 cites W3210054623 @default.
• W4205645563 cites W4234756224 @default.
• W4205645563 cites W4236920950 @default.
• W4205645563 cites W4251910888 @default.
• W4205645563 cites W4362197812 @default.
• W4205645563 doi "https://doi.org/10.3389/fmed.2021.798958" @default.
• W4205645563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35127755" @default.
• W4205645563 hasPublicationYear "2022" @default.
• W4205645563 type Work @default.
• W4205645563 citedByCount "63" @default.
• W4205645563 countsByYear W42056455632022 @default.
• W4205645563 countsByYear W42056455632023 @default.
• W4205645563 crossrefType "journal-article" @default.
• W4205645563 hasAuthorship W4205645563A5020814480 @default.
• W4205645563 hasAuthorship W4205645563A5031769855 @default.
• W4205645563 hasAuthorship W4205645563A5054282642 @default.
• W4205645563 hasBestOaLocation W42056455631 @default.

• next