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- W4205648958 abstract "Glucagon-like peptide-1 (GLP-1) is a peptide derived from differential processing of the precursor for the hormone glucagon. It is secreted predominantly by endocrine cells in the gut epithelium in response to nutrient stimulation. Studies from the last 35 years have given us an idea about its physiological functions. On the basis of some of its many actions, it has also been developed into a pharmaceutical agent for the treatment of obesity and type 2 diabetes (T2DM). It is currently positioned as the most effective anti-obesity agent available and is recommended in both national and international guidelines as an effective second-in line treatment for T2DM, in particular in patients with increased cardiovascular risk. In this review, I first discuss whether the processing of proglucagon may also result in GLP-1 formation in the pancreas and in glucagon in the gut. Next, I discuss the relationship between the physiological actions of GLP-1 and the therapeutic effects of the GLP-1 receptor agonists, which are far from being congruent and generally poorly understood. These relationships illustrate both the difficulties and the benefits of bridging results obtained in the laboratory with those emerging from the clinic." @default.
- W4205648958 created "2022-01-25" @default.
- W4205648958 creator A5085434984 @default.
- W4205648958 date "2022-01-24" @default.
- W4205648958 modified "2023-10-18" @default.
- W4205648958 title "Glucagon‐like peptide‐1: Are its roles as endogenous hormone and therapeutic wizard congruent?" @default.
- W4205648958 cites W1041790731 @default.
- W4205648958 cites W1494795869 @default.
- W4205648958 cites W1512370882 @default.
- W4205648958 cites W1582210525 @default.
- W4205648958 cites W1637070219 @default.
- W4205648958 cites W164778302 @default.
- W4205648958 cites W1903699177 @default.
- W4205648958 cites W1921480048 @default.
- W4205648958 cites W1945952457 @default.
- W4205648958 cites W1964212912 @default.
- W4205648958 cites W1965747302 @default.
- W4205648958 cites W1979288606 @default.
- W4205648958 cites W1979379931 @default.
- W4205648958 cites W1983109791 @default.
- W4205648958 cites W1983317997 @default.
- W4205648958 cites W1988405530 @default.
- W4205648958 cites W1989616977 @default.
- W4205648958 cites W1991263759 @default.
- W4205648958 cites W1991737556 @default.
- W4205648958 cites W1995482720 @default.
- W4205648958 cites W2001391476 @default.
- W4205648958 cites W2002171441 @default.
- W4205648958 cites W2003141714 @default.
- W4205648958 cites W2003572473 @default.
- W4205648958 cites W2004409542 @default.
- W4205648958 cites W2007879964 @default.
- W4205648958 cites W2008279427 @default.
- W4205648958 cites W2010787940 @default.
- W4205648958 cites W2013082477 @default.
- W4205648958 cites W2014156217 @default.
- W4205648958 cites W2017720492 @default.
- W4205648958 cites W2019549644 @default.
- W4205648958 cites W2020578808 @default.
- W4205648958 cites W2021022471 @default.
- W4205648958 cites W2024409703 @default.
- W4205648958 cites W2025931723 @default.
- W4205648958 cites W2029586722 @default.
- W4205648958 cites W2033087951 @default.
- W4205648958 cites W2033954313 @default.
- W4205648958 cites W2035284219 @default.
- W4205648958 cites W2036909990 @default.
- W4205648958 cites W2039423797 @default.
- W4205648958 cites W2045348654 @default.
- W4205648958 cites W2048809940 @default.
- W4205648958 cites W2053196978 @default.
- W4205648958 cites W2053720839 @default.
- W4205648958 cites W2057913111 @default.
- W4205648958 cites W2058922633 @default.
- W4205648958 cites W2061202826 @default.
- W4205648958 cites W2067233061 @default.
- W4205648958 cites W2071966058 @default.
- W4205648958 cites W2072237363 @default.
- W4205648958 cites W2074501705 @default.
- W4205648958 cites W2081276121 @default.
- W4205648958 cites W2086238197 @default.
- W4205648958 cites W2086565651 @default.
- W4205648958 cites W2094917076 @default.
- W4205648958 cites W2099223875 @default.
- W4205648958 cites W2106036385 @default.
- W4205648958 cites W2106339546 @default.
- W4205648958 cites W2106824929 @default.
- W4205648958 cites W2112981414 @default.
- W4205648958 cites W2117402345 @default.
- W4205648958 cites W2118991613 @default.
- W4205648958 cites W2119670027 @default.
- W4205648958 cites W2127409471 @default.
- W4205648958 cites W2140703820 @default.
- W4205648958 cites W2140978079 @default.
- W4205648958 cites W2143014102 @default.
- W4205648958 cites W2143069126 @default.
- W4205648958 cites W2143195699 @default.
- W4205648958 cites W2150137315 @default.
- W4205648958 cites W2152557643 @default.
- W4205648958 cites W2153950991 @default.
- W4205648958 cites W2163229244 @default.
- W4205648958 cites W2169914389 @default.
- W4205648958 cites W2196942236 @default.
- W4205648958 cites W2210262114 @default.
- W4205648958 cites W2337454357 @default.
- W4205648958 cites W2425644022 @default.
- W4205648958 cites W2519510391 @default.
- W4205648958 cites W2542456927 @default.
- W4205648958 cites W2587322147 @default.
- W4205648958 cites W2589545476 @default.
- W4205648958 cites W2595853302 @default.
- W4205648958 cites W2614800736 @default.
- W4205648958 cites W2757755247 @default.
- W4205648958 cites W2762892866 @default.
- W4205648958 cites W2790252631 @default.
- W4205648958 cites W2886598107 @default.
- W4205648958 cites W2899339394 @default.
- W4205648958 cites W2901979245 @default.