Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205650055> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4205650055 endingPage "80.e1" @default.
- W4205650055 startingPage "67" @default.
- W4205650055 abstract "Polmacoxib, a new coxib dually inhibiting cyclooxygenase-2 and carbonic anhydrase I/II, was recently approved for osteoarthritis treatment in South Korea. This study explored the population pharmacokinetic and pharmacodynamic characteristics of polmacoxib.Nonlinear mixed-effects modeling was performed using pooled pharmacokinetic data from a Phase I study in healthy individuals and pharmacokinetic properties and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) data from a Phase IIb study in patients with osteoarthritis. Pharmacodynamic models for WOMAC were sequentially fit using individual pharmacokinetic parameter estimates.Polmacoxib concentrations in whole blood were adequately described by the 2-compartment model, with mixed zero- and first-order absorption kinetics. Iron concentration was the significant covariate associated with clearance of polmacoxib. The relationship between the whole blood concentration of polmacoxib and WOMAC was best described by a 2-effect compartment model that consisted of central and peripheral compartments with the rate constant of 0.408 min-1 for distribution to the central effect compartment. A decrease in WOMAC was linked to the central effect site compartment concentration through an ordinary maximum effect model with an effect site concentration needed to achieve 50% of the maximum effect of 508 ng/mL.The current model accurately characterized the pharmacokinetic and pharmacodynamic properties of polmacoxib and could provide a basis for individualized drug therapy." @default.
- W4205650055 created "2022-01-25" @default.
- W4205650055 creator A5003763805 @default.
- W4205650055 creator A5022631166 @default.
- W4205650055 creator A5023423913 @default.
- W4205650055 creator A5026101027 @default.
- W4205650055 creator A5080900994 @default.
- W4205650055 date "2022-01-01" @default.
- W4205650055 modified "2023-10-16" @default.
- W4205650055 title "Population Pharmacokinetic and Pharmacodynamic Analysis of Polmacoxib in Healthy Volunteers and Patients With Osteoarthritis" @default.
- W4205650055 cites W1780627874 @default.
- W4205650055 cites W1884436975 @default.
- W4205650055 cites W1964056979 @default.
- W4205650055 cites W1984441096 @default.
- W4205650055 cites W1986079811 @default.
- W4205650055 cites W1990604933 @default.
- W4205650055 cites W1991950326 @default.
- W4205650055 cites W2022708774 @default.
- W4205650055 cites W2036491373 @default.
- W4205650055 cites W2054565825 @default.
- W4205650055 cites W2055395249 @default.
- W4205650055 cites W2065321505 @default.
- W4205650055 cites W2067866359 @default.
- W4205650055 cites W2072810447 @default.
- W4205650055 cites W2075256580 @default.
- W4205650055 cites W2077923150 @default.
- W4205650055 cites W2083741204 @default.
- W4205650055 cites W2084610846 @default.
- W4205650055 cites W2095935951 @default.
- W4205650055 cites W2145771743 @default.
- W4205650055 cites W2148371184 @default.
- W4205650055 cites W2149485684 @default.
- W4205650055 cites W2155820793 @default.
- W4205650055 cites W2158443299 @default.
- W4205650055 cites W2162299102 @default.
- W4205650055 cites W2163756514 @default.
- W4205650055 cites W2169625737 @default.
- W4205650055 cites W2223349637 @default.
- W4205650055 cites W2486185967 @default.
- W4205650055 doi "https://doi.org/10.1016/j.clinthera.2021.11.008" @default.
- W4205650055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34974943" @default.
- W4205650055 hasPublicationYear "2022" @default.
- W4205650055 type Work @default.
- W4205650055 citedByCount "1" @default.
- W4205650055 countsByYear W42056500552023 @default.
- W4205650055 crossrefType "journal-article" @default.
- W4205650055 hasAuthorship W4205650055A5003763805 @default.
- W4205650055 hasAuthorship W4205650055A5022631166 @default.
- W4205650055 hasAuthorship W4205650055A5023423913 @default.
- W4205650055 hasAuthorship W4205650055A5026101027 @default.
- W4205650055 hasAuthorship W4205650055A5080900994 @default.
- W4205650055 hasConcept C111113717 @default.
- W4205650055 hasConcept C112705442 @default.
- W4205650055 hasConcept C142724271 @default.
- W4205650055 hasConcept C204787440 @default.
- W4205650055 hasConcept C2776164576 @default.
- W4205650055 hasConcept C2776239304 @default.
- W4205650055 hasConcept C2779286237 @default.
- W4205650055 hasConcept C2908647359 @default.
- W4205650055 hasConcept C71924100 @default.
- W4205650055 hasConcept C98274493 @default.
- W4205650055 hasConcept C99454951 @default.
- W4205650055 hasConceptScore W4205650055C111113717 @default.
- W4205650055 hasConceptScore W4205650055C112705442 @default.
- W4205650055 hasConceptScore W4205650055C142724271 @default.
- W4205650055 hasConceptScore W4205650055C204787440 @default.
- W4205650055 hasConceptScore W4205650055C2776164576 @default.
- W4205650055 hasConceptScore W4205650055C2776239304 @default.
- W4205650055 hasConceptScore W4205650055C2779286237 @default.
- W4205650055 hasConceptScore W4205650055C2908647359 @default.
- W4205650055 hasConceptScore W4205650055C71924100 @default.
- W4205650055 hasConceptScore W4205650055C98274493 @default.
- W4205650055 hasConceptScore W4205650055C99454951 @default.
- W4205650055 hasIssue "1" @default.
- W4205650055 hasLocation W42056500551 @default.
- W4205650055 hasLocation W42056500552 @default.
- W4205650055 hasOpenAccess W4205650055 @default.
- W4205650055 hasPrimaryLocation W42056500551 @default.
- W4205650055 hasRelatedWork W1985286937 @default.
- W4205650055 hasRelatedWork W1988810699 @default.
- W4205650055 hasRelatedWork W2045407791 @default.
- W4205650055 hasRelatedWork W2095773979 @default.
- W4205650055 hasRelatedWork W2317839817 @default.
- W4205650055 hasRelatedWork W2322423563 @default.
- W4205650055 hasRelatedWork W3092039494 @default.
- W4205650055 hasRelatedWork W4312398015 @default.
- W4205650055 hasRelatedWork W4317104327 @default.
- W4205650055 hasRelatedWork W4327515429 @default.
- W4205650055 hasVolume "44" @default.
- W4205650055 isParatext "false" @default.
- W4205650055 isRetracted "false" @default.
- W4205650055 workType "article" @default.