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- W4205650101 abstract "Abstract Backgroud: Tumour recurrence and metastasis lead to poor prognosis in colon cancer (COAD). Therefore We aimed to identify a lncRNA signature through an integrative analysis of copy number variation, mutation and transcriptome data to predict prognosis and explore its internal mechanism.Methods: The lncRNA expression profile were collected from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). TCGA data was randomly divided 3:1 into training and testing cohort. In the training, we performed integrated analyses of three candidate lncRNA sets that correlated with prognosis, copy number variations and mutations to establish a signature through Cox regression analysis. The robustness was determined in the testing and GEO. Results: An 11-lncRNA signature that was significantly associated with prognosis was constructed in the training (P<0.0001, HR=2.014) , And this signature was validated in the testing (P=0.0019, HR=3.374) and GSE17536 (P=0.0076, HR=1.864). The signature is significantly related to MSI status and clinical prognostic factors. The prognostic-related risk scores were significantly excellent than the other five models have been reported. Furthermore, GSEA suggested that the signature was involved in COAD development and metastasis-related pathways.Conclusions: We identified an signature has strong robustness and can stably predict the prognosis of COAD in different platforms and may be implicated in COAD pathogenesis and metastasis and applied clinically as a prognostic marker." @default.
- W4205650101 created "2022-01-25" @default.
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- W4205650101 date "2021-02-04" @default.
- W4205650101 modified "2023-09-27" @default.
- W4205650101 title "Integrative Analysis and Identification of an Excellent lncRNA Signature to Predict Prognosis in Patients With Colon Cancer" @default.
- W4205650101 doi "https://doi.org/10.21203/rs.3.rs-153976/v1" @default.
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