FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205653933> ?p ?o ?g. }

• W4205653933 abstract "Aberrant activation of calmodulin 1 (CALM1) has been reported in human cancers. However, comprehensive understanding of the role of CALM1 in most cancer types has remained unclear. We systematically analyzed the expression landscape, DNA methylation, gene alteration, immune infiltration, clinical relevance, and molecular pathway of CALM1 in multiple cancers using various online tools, including The Cancer Genome Atlas, cBioPortal and the Human Protein Atlas databases. Kaplan-Meier and receiver operating characteristic (ROC) curves were plotted to explore the prognostic and diagnostic potential of CALM1 expression. Multivariate analyses were used to evaluate whether the CALM1 expression could be an independent risk factor. A nomogram predicting the overall survival (OS) of patients was developed, evaluated, and compared with the traditional Tumor-Node-Metastasis (TNM) model using decision curve analysis. R language was employed as the main tool for analysis and visualization. Results revealed CALM1 to be highly expressed in most cancers, its expression being regulated by DNA methylation in multiple cancers. CALM1 had a low mutation frequency (within 3%) and was associated with immune infiltration. We observed a substantial positive correlation between CALM1 expression and macrophage and neutrophil infiltration levels in multiple cancers. Different mutational forms of CALM1 hampered immune cell infiltration. Additionally, CALM1 expression had high diagnostic and prognostic potential. Multivariate analyses revealed CALM1 expression to be an independent risk factor for OS. Therefore, our newly developed nomogram had a higher clinical value than the TNM model. The concordance index, calibration curve, and time-dependent ROC curves of the nomogram exhibited excellent performance in terms of predicting the survival rate of patients. Moreover, elevated CALM1 expression contributes to the activation of cancer-related pathways, such as the WNT and MAPK pathways. Overall, our findings improved our understanding of the function of CALM1 in human cancers." @default.
• W4205653933 created "2022-01-25" @default.
• W4205653933 creator A5000336592 @default.
• W4205653933 creator A5069851134 @default.
• W4205653933 creator A5080793835 @default.
• W4205653933 creator A5084096798 @default.
• W4205653933 date "2022-01-12" @default.
• W4205653933 modified "2023-09-27" @default.
• W4205653933 title "In-Silico Multi-Omics Analysis of the Functional Significance of Calmodulin 1 in Multiple Cancers" @default.
• W4205653933 cites W1966107523 @default.
• W4205653933 cites W1985405860 @default.
• W4205653933 cites W1994607006 @default.
• W4205653933 cites W2035618305 @default.
• W4205653933 cites W2052366943 @default.
• W4205653933 cites W2109785769 @default.
• W4205653933 cites W2133380824 @default.
• W4205653933 cites W2149441684 @default.
• W4205653933 cites W2303253741 @default.
• W4205653933 cites W2594337087 @default.
• W4205653933 cites W2736730167 @default.
• W4205653933 cites W2743397410 @default.
• W4205653933 cites W2749042075 @default.
• W4205653933 cites W2765224588 @default.
• W4205653933 cites W2788148676 @default.
• W4205653933 cites W2793589490 @default.
• W4205653933 cites W2800301312 @default.
• W4205653933 cites W2884754721 @default.
• W4205653933 cites W2895856944 @default.
• W4205653933 cites W2900569176 @default.
• W4205653933 cites W2908785659 @default.
• W4205653933 cites W2915767933 @default.
• W4205653933 cites W2946657092 @default.
• W4205653933 cites W2980921743 @default.
• W4205653933 cites W3000663296 @default.
• W4205653933 cites W3000887590 @default.
• W4205653933 cites W3027286012 @default.
• W4205653933 cites W3039317077 @default.
• W4205653933 cites W3106746471 @default.
• W4205653933 cites W3118391223 @default.
• W4205653933 cites W3142673705 @default.
• W4205653933 cites W3193856798 @default.
• W4205653933 doi "https://doi.org/10.3389/fgene.2021.793508" @default.
• W4205653933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35096010" @default.
• W4205653933 hasPublicationYear "2022" @default.
• W4205653933 type Work @default.
• W4205653933 citedByCount "2" @default.
• W4205653933 countsByYear W42056539332022 @default.
• W4205653933 countsByYear W42056539332023 @default.
• W4205653933 crossrefType "journal-article" @default.
• W4205653933 hasAuthorship W4205653933A5000336592 @default.
• W4205653933 hasAuthorship W4205653933A5069851134 @default.
• W4205653933 hasAuthorship W4205653933A5080793835 @default.
• W4205653933 hasAuthorship W4205653933A5084096798 @default.
• W4205653933 hasBestOaLocation W42056539331 @default.
• W4205653933 hasConcept C104317684 @default.
• W4205653933 hasConcept C126322002 @default.
• W4205653933 hasConcept C143998085 @default.
• W4205653933 hasConcept C150194340 @default.
• W4205653933 hasConcept C18431079 @default.
• W4205653933 hasConcept C190727270 @default.
• W4205653933 hasConcept C34626388 @default.
• W4205653933 hasConcept C502942594 @default.
• W4205653933 hasConcept C54355233 @default.
• W4205653933 hasConcept C58471807 @default.
• W4205653933 hasConcept C71924100 @default.
• W4205653933 hasConcept C86803240 @default.
• W4205653933 hasConceptScore W4205653933C104317684 @default.
• W4205653933 hasConceptScore W4205653933C126322002 @default.
• W4205653933 hasConceptScore W4205653933C143998085 @default.
• W4205653933 hasConceptScore W4205653933C150194340 @default.
• W4205653933 hasConceptScore W4205653933C18431079 @default.
• W4205653933 hasConceptScore W4205653933C190727270 @default.
• W4205653933 hasConceptScore W4205653933C34626388 @default.
• W4205653933 hasConceptScore W4205653933C502942594 @default.
• W4205653933 hasConceptScore W4205653933C54355233 @default.
• W4205653933 hasConceptScore W4205653933C58471807 @default.
• W4205653933 hasConceptScore W4205653933C71924100 @default.
• W4205653933 hasConceptScore W4205653933C86803240 @default.
• W4205653933 hasFunder F4320327720 @default.
• W4205653933 hasFunder F4320335787 @default.
• W4205653933 hasLocation W42056539331 @default.
• W4205653933 hasLocation W42056539332 @default.
• W4205653933 hasLocation W42056539333 @default.
• W4205653933 hasLocation W42056539334 @default.
• W4205653933 hasOpenAccess W4205653933 @default.
• W4205653933 hasPrimaryLocation W42056539331 @default.
• W4205653933 hasRelatedWork W2120603712 @default.
• W4205653933 hasRelatedWork W2168316764 @default.
• W4205653933 hasRelatedWork W3012096999 @default.
• W4205653933 hasRelatedWork W3093526768 @default.
• W4205653933 hasRelatedWork W3200895526 @default.
• W4205653933 hasRelatedWork W3208351334 @default.
• W4205653933 hasRelatedWork W4310352383 @default.
• W4205653933 hasRelatedWork W4364378744 @default.
• W4205653933 hasRelatedWork W4377140011 @default.
• W4205653933 hasRelatedWork W4386086270 @default.
• W4205653933 hasVolume "12" @default.
• W4205653933 isParatext "false" @default.
• W4205653933 isRetracted "false" @default.
• W4205653933 workType "article" @default.