FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205656747> ?p ?o ?g. }

• W4205656747 endingPage "R135" @default.
• W4205656747 startingPage "R126" @default.
• W4205656747 abstract "Many lung diseases are caused by an excessive inflammatory response, and inflammatory lung diseases are often modeled using lipopolysaccharide (LPS) in mice. Cyclooxygenase-2 (COX-2) encoded by the Ptgs2 gene is induced in response to inflammatory stimuli including LPS. The objective of this study was to test the hypothesis that mice deficient in COX-2 ( Ptgs2 -/- ) will be protected from LPS-induced lung injury. Wild-type (WT; CD1 mice) and Ptgs2 -/- mice (on a CD1 background) were treated with LPS or vehicle for 24 h. LPS treatment resulted in histological evidence of lung injury, which was attenuated in the Ptgs2 -/- mice. LPS treatment increased the mRNA levels for tumor necrosis factor-α, interleukin-10, and monocyte chemoattractant protein-1 in the lungs of WT mice, and the LPS-induced increases in these levels were attenuated in the Ptgs2 -/- mice. The protein levels of active caspase-3 and caspase-9 were lower in the LPS-treated lungs of Ptgs2 -/- mice than in LPS-treated WT mice, as were the number of terminal deoxynucleotide transferase dUTP nick end labeling-positive cells in lung sections. LPS exposure resulted in a greater lung wet-to-dry weight ratio (W/D) in WT mice, suggestive of pulmonary edema, while in LPS-treated Ptgs2 -/- mice, the W/D was not different from controls and less than in LPS-treated WT mice. These results demonstrate that COX-2 is involved in the inflammatory response to LPS and suggest that COX-2 not only acts as a downstream participant in the inflammatory response, but also acts as a regulator of the inflammatory response likely through a feed-forward mechanism following LPS stimulation." @default.
• W4205656747 created "2022-01-26" @default.
• W4205656747 creator A5010579783 @default.
• W4205656747 creator A5015638413 @default.
• W4205656747 creator A5067574356 @default.
• W4205656747 creator A5076167118 @default.
• W4205656747 creator A5076748283 @default.
• W4205656747 creator A5077701476 @default.
• W4205656747 date "2022-02-01" @default.
• W4205656747 modified "2023-10-14" @default.
• W4205656747 title "Cyclooxygenase-2 deficiency attenuates lipopolysaccharide-induced inflammation, apoptosis, and acute lung injury in adult mice" @default.
• W4205656747 cites W1157168957 @default.
• W4205656747 cites W1983003192 @default.
• W4205656747 cites W1986861290 @default.
• W4205656747 cites W1992490895 @default.
• W4205656747 cites W1999682348 @default.
• W4205656747 cites W2000947149 @default.
• W4205656747 cites W2024160120 @default.
• W4205656747 cites W2026303741 @default.
• W4205656747 cites W2033886716 @default.
• W4205656747 cites W2034972265 @default.
• W4205656747 cites W2045525839 @default.
• W4205656747 cites W2051921682 @default.
• W4205656747 cites W2058405007 @default.
• W4205656747 cites W2068260789 @default.
• W4205656747 cites W2099152203 @default.
• W4205656747 cites W2114072838 @default.
• W4205656747 cites W2115866619 @default.
• W4205656747 cites W2120242825 @default.
• W4205656747 cites W2121916105 @default.
• W4205656747 cites W2151788240 @default.
• W4205656747 cites W2169196822 @default.
• W4205656747 cites W2169259339 @default.
• W4205656747 cites W2261614590 @default.
• W4205656747 cites W2288465238 @default.
• W4205656747 cites W2555467097 @default.
• W4205656747 cites W2590356973 @default.
• W4205656747 cites W2617729831 @default.
• W4205656747 cites W2620241325 @default.
• W4205656747 cites W2772652039 @default.
• W4205656747 cites W2783388357 @default.
• W4205656747 cites W2790632158 @default.
• W4205656747 cites W2810138159 @default.
• W4205656747 cites W2899900459 @default.
• W4205656747 cites W2908746587 @default.
• W4205656747 cites W2953053535 @default.
• W4205656747 cites W2972382464 @default.
• W4205656747 cites W3034867188 @default.
• W4205656747 cites W3038049609 @default.
• W4205656747 cites W3048552244 @default.
• W4205656747 cites W3087272870 @default.
• W4205656747 cites W3171259798 @default.
• W4205656747 doi "https://doi.org/10.1152/ajpregu.00140.2021" @default.
• W4205656747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34984926" @default.
• W4205656747 hasPublicationYear "2022" @default.
• W4205656747 type Work @default.
• W4205656747 citedByCount "5" @default.
• W4205656747 countsByYear W42056567472022 @default.
• W4205656747 countsByYear W42056567472023 @default.
• W4205656747 crossrefType "journal-article" @default.
• W4205656747 hasAuthorship W4205656747A5010579783 @default.
• W4205656747 hasAuthorship W4205656747A5015638413 @default.
• W4205656747 hasAuthorship W4205656747A5067574356 @default.
• W4205656747 hasAuthorship W4205656747A5076167118 @default.
• W4205656747 hasAuthorship W4205656747A5076748283 @default.
• W4205656747 hasAuthorship W4205656747A5077701476 @default.
• W4205656747 hasBestOaLocation W42056567472 @default.
• W4205656747 hasConcept C126322002 @default.
• W4205656747 hasConcept C134018914 @default.
• W4205656747 hasConcept C17991360 @default.
• W4205656747 hasConcept C181199279 @default.
• W4205656747 hasConcept C190283241 @default.
• W4205656747 hasConcept C203014093 @default.
• W4205656747 hasConcept C2776914184 @default.
• W4205656747 hasConcept C2777714996 @default.
• W4205656747 hasConcept C2778754761 @default.
• W4205656747 hasConcept C2779689624 @default.
• W4205656747 hasConcept C55493867 @default.
• W4205656747 hasConcept C71924100 @default.
• W4205656747 hasConcept C86803240 @default.
• W4205656747 hasConceptScore W4205656747C126322002 @default.
• W4205656747 hasConceptScore W4205656747C134018914 @default.
• W4205656747 hasConceptScore W4205656747C17991360 @default.
• W4205656747 hasConceptScore W4205656747C181199279 @default.
• W4205656747 hasConceptScore W4205656747C190283241 @default.
• W4205656747 hasConceptScore W4205656747C203014093 @default.
• W4205656747 hasConceptScore W4205656747C2776914184 @default.
• W4205656747 hasConceptScore W4205656747C2777714996 @default.
• W4205656747 hasConceptScore W4205656747C2778754761 @default.
• W4205656747 hasConceptScore W4205656747C2779689624 @default.
• W4205656747 hasConceptScore W4205656747C55493867 @default.
• W4205656747 hasConceptScore W4205656747C71924100 @default.
• W4205656747 hasConceptScore W4205656747C86803240 @default.
• W4205656747 hasIssue "2" @default.
• W4205656747 hasLocation W42056567471 @default.
• W4205656747 hasLocation W42056567472 @default.
• W4205656747 hasLocation W42056567473 @default.
• W4205656747 hasOpenAccess W4205656747 @default.

• next