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- W4205672035 abstract "Abstract An important component of efforts to manage the ongoing COVID19 pandemic is the R apid A ssessment of how natural selection contributes to the emergence and proliferation of potentially dangerous S ARS-CoV-2 lineages and CL ades (RASCL). The RASCL pipeline enables continuous comparative phylogenetics-based selection analyses of rapidly growing clade-focused genome surveillance datasets, such as those produced following the initial detection of potentially dangerous variants. From such datasets RASCL automatically generates down-sampled codon alignments of individual genes/ORFs containing contextualizing background reference sequences, analyzes these with a battery of selection tests, and outputs results as both machine readable JSON files, and interactive notebook-based visualizations. Availability RASCL is available from a dedicated repository at https://github.com/veg/RASCL and as a Galaxy workflow https://usegalaxy.eu/u/hyphy/w/rascl . Existing clade/variant analysis results are available here: https://observablehq.com/@aglucaci/rascl . Contact Dr. Sergei L Kosakovsky Pond ( spond@temple.edu ). Supplementary information N/A" @default.
- W4205672035 created "2022-01-26" @default.
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- W4205672035 date "2022-01-18" @default.
- W4205672035 modified "2023-10-18" @default.
- W4205672035 title "RASCL: Rapid Assessment Of SARS-CoV-2 Clades Through Molecular Sequence Analysis" @default.
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- W4205672035 doi "https://doi.org/10.1101/2022.01.15.476448" @default.
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