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• W4205679968 abstract "The identification and validation of biomarkers in hidradenitis suppurativa (HS) has potential to improve the understanding and management of this chronic, burdensome disease.To systematically identify all known HS biomarkers, categorize them by biomarker type, and critically evaluate their validity according to established criteria.Eligibility criteria for this review (PROSPERO Registration 230830) included randomized clinical trials, uncontrolled clinical trials, cohort studies, case-control studies, and other observational studies with no restrictions of patient age, sex, race or ethnicity, or language of publication up until December 31, 2020. All articles were categorized into biomarker type, defined using the US Food and Drug Administration Biomarkers, Endpoints, and other Tools (BEST) glossary. Assessment of each identified biomarker was undertaken in line with the US Food and Drug Administration and European Medicines Agency guidelines for the validation of proposed biomarkers. Assessment of the strength of overall data regarding individual biomarkers was undertaken using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach.A total of 3953 nonduplicate articles were screened, of which 1429 articles were retrieved based on the include/exclusion criteria applied. After full-text screen and data extraction, 106 articles were included in this review. The evidence of strength of 6 categories of biomarkers (susceptibility/risk, diagnostic, monitoring, predictive, prognostic, and pharmacodynamic/response biomarkers) was assessed using GRADE criteria. A total of 48 biomarkers were identified with a minimum GRADE rating of moderate. Only 1 diagnostic (serum IL-2R), 1 monitoring (dermal Doppler vascularity), and 2 predictive biomarkers (epithelialized tunnels and positive family history of HS) achieved a GRADE rating of high. None of the identified biomarkers had sufficient clinical validity to be recommended for routine use in the clinical setting.Major barriers to the identification, validation, and introduction of routine biomarkers in the management of HS include lack of independent biomarker validation studies (especially assumption-free omics-based techniques); insufficient assessment of collinearity between identified or proposed biomarkers; and a lack of routine integration of biomarkers into the structure of clinical trials. International consensus among researchers, clinicians, and pharmaceutical stakeholders is required to standardize goals and methods and encourage biomarker integration into future HS clinical trials. This systematic review presents a number of priorities for near-term future research to overcome such barriers and limitations of biomarkers in HS." @default.
• W4205679968 created "2022-01-25" @default.
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• W4205679968 date "2022-03-01" @default.
• W4205679968 modified "2023-09-29" @default.
• W4205679968 title "Identification of Biomarkers and Critical Evaluation of Biomarker Validation in Hidradenitis Suppurativa" @default.
• W4205679968 cites W1581869568 @default.
• W4205679968 cites W1721642365 @default.
• W4205679968 cites W1770130443 @default.
• W4205679968 cites W1825622469 @default.
• W4205679968 cites W1867780443 @default.
• W4205679968 cites W1905011311 @default.
• W4205679968 cites W1961929855 @default.
• W4205679968 cites W1969199357 @default.
• W4205679968 cites W1997472231 @default.
• W4205679968 cites W2107021177 @default.
• W4205679968 cites W2110755088 @default.
• W4205679968 cites W2139125221 @default.
• W4205679968 cites W2146730690 @default.
• W4205679968 cites W2149773242 @default.
• W4205679968 cites W2160965670 @default.
• W4205679968 cites W2168114675 @default.
• W4205679968 cites W2168368456 @default.
• W4205679968 cites W2180456455 @default.
• W4205679968 cites W2224237734 @default.
• W4205679968 cites W2332775272 @default.
• W4205679968 cites W2346275821 @default.
• W4205679968 cites W2406935300 @default.
• W4205679968 cites W2503109448 @default.
• W4205679968 cites W2562114632 @default.
• W4205679968 cites W2564885013 @default.
• W4205679968 cites W2567077409 @default.
• W4205679968 cites W2592494139 @default.
• W4205679968 cites W2604277285 @default.
• W4205679968 cites W2617357797 @default.
• W4205679968 cites W2694182897 @default.
• W4205679968 cites W2734622066 @default.
• W4205679968 cites W2756574903 @default.
• W4205679968 cites W2758853776 @default.
• W4205679968 cites W2774922248 @default.
• W4205679968 cites W2774941976 @default.
• W4205679968 cites W2778320654 @default.
• W4205679968 cites W2788093269 @default.
• W4205679968 cites W2789591663 @default.
• W4205679968 cites W2793440013 @default.
• W4205679968 cites W2806696712 @default.
• W4205679968 cites W2895032143 @default.
• W4205679968 cites W2898506731 @default.
• W4205679968 cites W2899371277 @default.
• W4205679968 cites W2900362695 @default.
• W4205679968 cites W2903052440 @default.
• W4205679968 cites W2944599630 @default.
• W4205679968 cites W2945571987 @default.
• W4205679968 cites W2946619968 @default.
• W4205679968 cites W2947361380 @default.
• W4205679968 cites W2954357071 @default.
• W4205679968 cites W2954442944 @default.
• W4205679968 cites W2960743018 @default.
• W4205679968 cites W2969440303 @default.
• W4205679968 cites W2970393203 @default.
• W4205679968 cites W2970751757 @default.
• W4205679968 cites W2971609950 @default.
• W4205679968 cites W2972342800 @default.
• W4205679968 cites W2973329262 @default.
• W4205679968 cites W2977229878 @default.
• W4205679968 cites W2979544789 @default.
• W4205679968 cites W2985289876 @default.
• W4205679968 cites W2987519893 @default.
• W4205679968 cites W2990597961 @default.
• W4205679968 cites W2997740954 @default.
• W4205679968 cites W2998567132 @default.
• W4205679968 cites W2999862077 @default.
• W4205679968 cites W2999898636 @default.
• W4205679968 cites W3004088921 @default.
• W4205679968 cites W3009514032 @default.
• W4205679968 cites W3019434847 @default.
• W4205679968 cites W3023064917 @default.
• W4205679968 cites W3027588706 @default.
• W4205679968 cites W3036601175 @default.
• W4205679968 cites W3037431440 @default.
• W4205679968 cites W3039504105 @default.
• W4205679968 cites W3080707874 @default.
• W4205679968 cites W3080991193 @default.
• W4205679968 cites W3084437562 @default.
• W4205679968 cites W3084587260 @default.
• W4205679968 cites W3087112323 @default.
• W4205679968 cites W3087951185 @default.
• W4205679968 cites W3088849667 @default.
• W4205679968 cites W3091647130 @default.
• W4205679968 cites W3092201977 @default.

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