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• W4205681761 abstract "Abstract Purpose Patients with inherited retinal diseases (IRDs) share altered retinal metabolic function. The aim of our study was to investigate the relationship between retinal metabolic alterations (retinal vessel Oximetry, RO) and structural findings (central retinal thickness and retinal nerve fibre layer thickness, RNFL) in IRDs. Methods A total of 181 eyes of 92 subjects were examined: 121 eyes of 62 patients with IRDs were compared to 60 eyes of 30 healthy age‐matched controls. The retinal vessel oximetry was performed with the oxygen saturation measurement tool of the Retinal Vessel Analyser (RVA; IMEDOS Systems UG, Jena, Germany). The oxygen saturation in all four major peripapillary retinal arterioles (A‐SO2; %) and venules (V‐SO2; %) were measured and their difference (A‐V SO2; %) was calculated. In addition, we calculated the mean central retinal oxygen exposure (cO2‐E; %/µm) and the mean peripapillary oxygen exposure (pO2‐E; %/µm) per micron of central retinal thickness and nerve fibre layer thickness. Results Rod‐cone dystrophy patients had the highest V‐SO2 and A‐SO2, the lowest A‐V SO2, the narrower D‐A and D‐V and the thickest RNFL, when compared to controls (p≤0.040), but also to patients with other IRDs. Furthermore, in rod‐cone dystrophies, the cO2‐E and the pO2‐E were higher in comparison to controls and to patients with other IRDs (p≤0.005). Cone‐rod dystrophy patients had the lowest cO2‐E compared to controls and patients with other IRDs (p≤0.035). Evaluated in central zones, the cO2‐E was significantly different when comparing CRD‐ against RCD patients in all zones (p<0.001), whereas against controls and patients with inherited macular dystrophy only in zones 1 and 2 (p≤0.018). The oxygen exposure was also the highest in the RCD, for both the nasal and the temporal peripapillary area among evaluated groups (p ≤ 0.025) Conclusions Clearly demonstrated through the O2‐E comparisons, rod‐cone dystrophy eyes seem to be more exposed to oxygen, the later presumably leading to more pronounced oxidative damage‐related remodeling." @default.
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• W4205681761 date "2022-01-01" @default.
• W4205681761 modified "2023-09-26" @default.
• W4205681761 title "Oxygen exposure in inherited diseases of the retina" @default.
• W4205681761 doi "https://doi.org/10.1111/j.1755-3768.2022.063" @default.
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