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- W4205683657 abstract "The spread of multi-drug resistance in bacteria is of profound significance. In pathogenic bacteria, several drug targets are the focus of drug development companies and research groups. The bacterial DNA gyrase and topoisomerase are two such important drug targets to control the bacterial infection and its spread of multi-drug resistance. The resistance produced to the various quinolone inhibitors results in targeting these enzymes through other non-quinolone based inhibitors. In this work, we have focused on the development of non-quinolone inhibitors of bacterial DNA gyrase and topoisomerase IV. The development of non-quinolone inhibitors showed lower resistance and favorable potency against both Gram positive and Gram-negative bacteria. Presently various non-quinolone based compounds are in different phases of clinical trials." @default.
- W4205683657 created "2022-01-25" @default.
- W4205683657 creator A5052484053 @default.
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- W4205683657 date "2022-01-01" @default.
- W4205683657 modified "2023-09-27" @default.
- W4205683657 title "Non-Quinolone Inhibitors of the Bacterial DNA Gyrase" @default.
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- W4205683657 doi "https://doi.org/10.1016/b978-0-12-820472-6.00177-8" @default.
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