FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205684527> ?p ?o ?g. }

• W4205684527 endingPage "1216" @default.
• W4205684527 startingPage "1207" @default.
• W4205684527 abstract "Electroencephalogram (EEG) discontinuity can occur at high concentrations of anesthetic drugs, reflecting suppression of electrocortical activity. This EEG pattern has been reported in children and reflects a deep state of anesthesia. Isoelectric events on the EEG, a more extreme degree of voltage suppression, have been shown to be associated with worse long-term neurologic outcomes in neonates undergoing cardiac surgery. However, the clinical significance of EEG discontinuities during pediatric anesthesia for noncardiac surgery is not yet known and merits further research. In this study, we assessed the incidence of EEG discontinuity during anesthesia induction in neurologically normal infants and the clinical factors associated with its development. We hypothesized that EEG discontinuity would be associated with sevoflurane-induced alpha (8-12 Hz) power during the period of anesthesia induction in infants.We prospectively recorded 26 channels of EEG during anesthesia induction in an observational cohort of 54 infants (median age, 7.6 months; interquartile range [IQR] [4.9-9.8 months]). We identified EEG discontinuity, defined as voltage amplitude <25 microvolts for >2 seconds, and assessed its association with sevoflurane-induced alpha power using spectral analysis and multivariable logistic regression adjusting for clinically important variables.EEG discontinuity was observed in 20 of 54 subjects (37%), with a total of 25 discrete events. Sevoflurane-induced alpha power in the posterior regions of the head (eg, parietal or occipital regions) was significantly lower in the EEG discontinuity group (midline parietal channel on the electroencephalogram, International 10-20 System [Pz]; 8.3 vs 11.2 decibels [dBs]; P = .004), and this association remained after multivariable adjustment (adjusted odds ratio [aOR] = 0.51 per dB increase in alpha power [95% CI, 0.30-0.89]; P = .02). There were no differences in the baseline (unanesthetized) EEG between groups in alpha power or power in any other frequency band.We demonstrate that EEG discontinuity is common during anesthesia induction and is related to the level of sevoflurane-induced posterior alpha power, a putative marker of cortical-thalamic circuit development in the first year of life. This association persisted even after adjusting for age and propofol coadministration. The fact that this difference was only observed during anesthesia and not in the baseline EEG suggests that otherwise hidden brain circuit properties are unmasked by general anesthesia. These neurophysiologic markers observed during anesthesia may be useful in identifying patients who may have a greater chance of developing discontinuity." @default.
• W4205684527 created "2022-01-26" @default.
• W4205684527 creator A5004287385 @default.
• W4205684527 creator A5005240128 @default.
• W4205684527 creator A5015157558 @default.
• W4205684527 creator A5028617330 @default.
• W4205684527 creator A5029426986 @default.
• W4205684527 creator A5031904499 @default.
• W4205684527 creator A5055366628 @default.
• W4205684527 creator A5064828851 @default.
• W4205684527 creator A5086230340 @default.
• W4205684527 date "2022-11-16" @default.
• W4205684527 modified "2023-10-11" @default.
• W4205684527 title "Decreased Electroencephalographic Alpha Power During Anesthesia Induction Is Associated With EEG Discontinuity in Human Infants" @default.
• W4205684527 cites W1950544107 @default.
• W4205684527 cites W1955974438 @default.
• W4205684527 cites W1967792486 @default.
• W4205684527 cites W1978956684 @default.
• W4205684527 cites W2002996884 @default.
• W4205684527 cites W2015304937 @default.
• W4205684527 cites W2016956756 @default.
• W4205684527 cites W2024313504 @default.
• W4205684527 cites W2038382211 @default.
• W4205684527 cites W2058059437 @default.
• W4205684527 cites W2090072589 @default.
• W4205684527 cites W2156035345 @default.
• W4205684527 cites W2166073443 @default.
• W4205684527 cites W2207920805 @default.
• W4205684527 cites W2215889409 @default.
• W4205684527 cites W2550190802 @default.
• W4205684527 cites W2580018307 @default.
• W4205684527 cites W2586524372 @default.
• W4205684527 cites W2605705348 @default.
• W4205684527 cites W2725161969 @default.
• W4205684527 cites W2737674920 @default.
• W4205684527 cites W2738237448 @default.
• W4205684527 cites W2767375284 @default.
• W4205684527 cites W2808314891 @default.
• W4205684527 cites W2885723710 @default.
• W4205684527 cites W2898186910 @default.
• W4205684527 cites W2912852742 @default.
• W4205684527 cites W2918317484 @default.
• W4205684527 cites W2946262173 @default.
• W4205684527 cites W2970659214 @default.
• W4205684527 cites W2971570110 @default.
• W4205684527 cites W2978116648 @default.
• W4205684527 cites W2981152026 @default.
• W4205684527 cites W3008244561 @default.
• W4205684527 cites W3021572469 @default.
• W4205684527 cites W3025945084 @default.
• W4205684527 cites W3033242681 @default.
• W4205684527 cites W3197314412 @default.
• W4205684527 doi "https://doi.org/10.1213/ane.0000000000005864" @default.
• W4205684527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35041633" @default.
• W4205684527 hasPublicationYear "2022" @default.
• W4205684527 type Work @default.
• W4205684527 citedByCount "6" @default.
• W4205684527 countsByYear W42056845272022 @default.
• W4205684527 countsByYear W42056845272023 @default.
• W4205684527 crossrefType "journal-article" @default.
• W4205684527 hasAuthorship W4205684527A5004287385 @default.
• W4205684527 hasAuthorship W4205684527A5005240128 @default.
• W4205684527 hasAuthorship W4205684527A5015157558 @default.
• W4205684527 hasAuthorship W4205684527A5028617330 @default.
• W4205684527 hasAuthorship W4205684527A5029426986 @default.
• W4205684527 hasAuthorship W4205684527A5031904499 @default.
• W4205684527 hasAuthorship W4205684527A5055366628 @default.
• W4205684527 hasAuthorship W4205684527A5064828851 @default.
• W4205684527 hasAuthorship W4205684527A5086230340 @default.
• W4205684527 hasConcept C118552586 @default.
• W4205684527 hasConcept C119060515 @default.
• W4205684527 hasConcept C141071460 @default.
• W4205684527 hasConcept C167639399 @default.
• W4205684527 hasConcept C2781453256 @default.
• W4205684527 hasConcept C42219234 @default.
• W4205684527 hasConcept C522805319 @default.
• W4205684527 hasConcept C71924100 @default.
• W4205684527 hasConceptScore W4205684527C118552586 @default.
• W4205684527 hasConceptScore W4205684527C119060515 @default.
• W4205684527 hasConceptScore W4205684527C141071460 @default.
• W4205684527 hasConceptScore W4205684527C167639399 @default.
• W4205684527 hasConceptScore W4205684527C2781453256 @default.
• W4205684527 hasConceptScore W4205684527C42219234 @default.
• W4205684527 hasConceptScore W4205684527C522805319 @default.
• W4205684527 hasConceptScore W4205684527C71924100 @default.
• W4205684527 hasIssue "6" @default.
• W4205684527 hasLocation W42056845271 @default.
• W4205684527 hasLocation W42056845272 @default.
• W4205684527 hasOpenAccess W4205684527 @default.
• W4205684527 hasPrimaryLocation W42056845271 @default.
• W4205684527 hasRelatedWork W1486358149 @default.
• W4205684527 hasRelatedWork W1988700645 @default.
• W4205684527 hasRelatedWork W2014958702 @default.
• W4205684527 hasRelatedWork W2024326443 @default.
• W4205684527 hasRelatedWork W2074565735 @default.
• W4205684527 hasRelatedWork W2158649361 @default.
• W4205684527 hasRelatedWork W2398472035 @default.
• W4205684527 hasRelatedWork W2946923044 @default.

• next