Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205707989> ?p ?o ?g. }
Showing items 1 to 49 of
49
with 100 items per page.
- W4205707989 abstract "Abstract Background: Topamax® ® has multiple pharmacological mechanisms that are efficient to treat epilepsy and migraine. Ginger has been demonstrated to have gingerols and shogaols compounds that proven to cross the blood-brain barrier causing migraine relief, implying that it is useful in the treatment of migraines. Moreover, Topamax has many off-label uses. So it was necessary to explore the possible neurotoxicity of Topamax®, Ginger oil and their interaction in the mice brain. Methods and Results : Male mice were orally gavage with Topamax®, ginger oil (400mg/kg), and Topamax® plus ginger oil with the same pattern for one month. Oxidative stress markers, acetylcholinesterase (AchE) and gamma aminobutyric acid (GABA) and tumor necrosis factor-alpha (TNF- α), were analyzed in brain tissue. Histopathological examination by hematoxylin and eosin, immunohistochemical glial fibrillary acidic protein (GFAP), and Bax expression analysis were done. The mRNA levels of GABAAR subunits, Gabra1, Gabra3, and Gabra5 were evaluated by RT qPCR. The analysis of data revealed that Topamax® elevated the levels of oxidative stress markers, neurotransmitters, TNF-α, and diminished the level of glutathione reduced (GSH). Topamax® exhibited various neuropathological alterations, strong Bax expression, and GFAP immune-reactivity in the cerebral cortex. The interaction effect of Topamax® plus ginger oil attenuated the changes induced by Topamax® in the abovementioned parameters. Both Topamax® and ginger oil upregulated the mRNA expression of gabra1 and gabra3 while their interaction markedly downregulated them. Conclusion: We can conclude that the Topamax® overdose could possibly cause neurotoxicity, but the interaction with ginger oil can reduce Topamax® -induced neurotoxicity and should be taken in parallel." @default.
- W4205707989 created "2022-01-25" @default.
- W4205707989 creator A5052106575 @default.
- W4205707989 creator A5052385508 @default.
- W4205707989 creator A5058782797 @default.
- W4205707989 creator A5064978300 @default.
- W4205707989 date "2022-01-07" @default.
- W4205707989 modified "2023-10-16" @default.
- W4205707989 title "Topamax® and Ginger Oil Potential Neurotoxicity And Their Interaction in Mice Thru Oxidative Stress and Inflammatory Markers, Neurotransmitters Expression and Immunohistochemical Measurements" @default.
- W4205707989 doi "https://doi.org/10.21203/rs.3.rs-1173182/v1" @default.
- W4205707989 hasPublicationYear "2022" @default.
- W4205707989 type Work @default.
- W4205707989 citedByCount "0" @default.
- W4205707989 crossrefType "posted-content" @default.
- W4205707989 hasAuthorship W4205707989A5052106575 @default.
- W4205707989 hasAuthorship W4205707989A5052385508 @default.
- W4205707989 hasAuthorship W4205707989A5058782797 @default.
- W4205707989 hasAuthorship W4205707989A5064978300 @default.
- W4205707989 hasBestOaLocation W42057079891 @default.
- W4205707989 hasConcept C126322002 @default.
- W4205707989 hasConcept C134018914 @default.
- W4205707989 hasConcept C2776151105 @default.
- W4205707989 hasConcept C2779491297 @default.
- W4205707989 hasConcept C29730261 @default.
- W4205707989 hasConcept C71924100 @default.
- W4205707989 hasConcept C98274493 @default.
- W4205707989 hasConceptScore W4205707989C126322002 @default.
- W4205707989 hasConceptScore W4205707989C134018914 @default.
- W4205707989 hasConceptScore W4205707989C2776151105 @default.
- W4205707989 hasConceptScore W4205707989C2779491297 @default.
- W4205707989 hasConceptScore W4205707989C29730261 @default.
- W4205707989 hasConceptScore W4205707989C71924100 @default.
- W4205707989 hasConceptScore W4205707989C98274493 @default.
- W4205707989 hasLocation W42057079891 @default.
- W4205707989 hasOpenAccess W4205707989 @default.
- W4205707989 hasPrimaryLocation W42057079891 @default.
- W4205707989 hasRelatedWork W1845232696 @default.
- W4205707989 hasRelatedWork W2054625401 @default.
- W4205707989 hasRelatedWork W2066059435 @default.
- W4205707989 hasRelatedWork W2704339979 @default.
- W4205707989 hasRelatedWork W3022336324 @default.
- W4205707989 hasRelatedWork W3123937641 @default.
- W4205707989 hasRelatedWork W3207431744 @default.
- W4205707989 hasRelatedWork W4297019876 @default.
- W4205707989 hasRelatedWork W4319596247 @default.
- W4205707989 hasRelatedWork W4321793368 @default.
- W4205707989 isParatext "false" @default.
- W4205707989 isRetracted "false" @default.
- W4205707989 workType "article" @default.