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- W4205718150 abstract "T cell circulation between peripheral tissues and the lymphoid compartment is critical for immunosurveillance and host defense. However, the factors that determine whether T cells remain in peripheral tissue or return to the circulation are undefined. Here we demonstrate that the chemokine receptor CCR7 is a critical signal that determines T cell exit from peripheral tissue. Both CCR7(-) and CCR7(+) effector T cells entered mouse asthmatic lung and while CCR7(-) T cells accumulated, CCR7(+) T cells continued to migrate into afferent lymph. Delivery of both CCR7(+) and CCR7(-) T cells directly into the airways showed that only CCR7(+) T cells exited the lung and entered draining lymph nodes. Our study establishes a molecular basis for T cell exit from peripheral tissues. PMID: 16116469 Funding information This work was supported by: NIAID NIH HHS, United States Grant ID: R01-AI40618 NIAID NIH HHS, United States Grant ID: F32-AI054107" @default.
- W4205718150 created "2022-01-26" @default.
- W4205718150 creator A5080784954 @default.
- W4205718150 date "2005-08-24" @default.
- W4205718150 modified "2023-09-27" @default.
- W4205718150 title "Faculty Opinions recommendation of Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics." @default.
- W4205718150 doi "https://doi.org/10.3410/f.1027634.332652" @default.
- W4205718150 hasPublicationYear "2005" @default.
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