FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205742762> ?p ?o ?g. }

• W4205742762 endingPage "83" @default.
• W4205742762 startingPage "77" @default.
• W4205742762 abstract "Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, an increasing number of chilblain-like lesions (ChLL) have been increasingly reported worldwide. To date, the causal link between ChLL and SARS-CoV-2 infection has not been unequivocally established.In this case series, we present demographic, clinical, laboratory, and histopathological information regarding 27 young patients with a clinical diagnosis of ChLL who referred to the Dermatology Unit of Papa Giovanni XXIII Hospital, Bergamo, Italy, from 1 April 2020 to 1 June 2020.The mean age was 14.2 years, and 21 patients (78%) experienced mild systemic symptoms a median of 28 days before the onset of cutaneous lesions. ChLL mostly involved the feet (20 patients - 74%). Among acral lesions, we identified three different clinical patterns: (i) chilblains in 20 patients (74%); (ii) fixed erythematous macules in 4 children (15%); (iii) erythrocyanosis in 3 female patients (11%). Blood examinations and viral serologies, including parvovirus B19, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and coxsackievirus were normal in all. Three patients (11%) underwent nasopharyngeal swab for RT-PCR for SARS-CoV-2 showing only 1 positive. Histopathological examinations of 7 skin biopsies confirmed the clinical diagnosis of chilblains; vessel thrombi were observed only in 1 case. Our findings failed to demonstrate the direct presence of SARS-CoV-2 RNA in skin biopsies, both with real-time polymerase chain reaction (RT-PCR) and RNAscope in situ hybridization (ISH).Limited number of cases, unavailability of laboratory confirmation of COVID-19 in all patients, potential methodological weakness, and latency of skin biopsies in comparison to cutaneous lesions onset.These observations may support the hypothesis of an inflammatory pathogenesis rather than the presence of peripheral viral particles. Although, we could not exclude an early phase of viral endothelial damage followed by an IFN-I or complement-mediated inflammatory phase. Further observations on a large number of patients are needed to confirm this hypothesis." @default.
• W4205742762 created "2022-01-25" @default.
• W4205742762 creator A5001655675 @default.
• W4205742762 creator A5012969542 @default.
• W4205742762 creator A5024677633 @default.
• W4205742762 creator A5043435667 @default.
• W4205742762 creator A5057447510 @default.
• W4205742762 creator A5063147525 @default.
• W4205742762 creator A5074410273 @default.
• W4205742762 creator A5075188736 @default.
• W4205742762 creator A5083335316 @default.
• W4205742762 creator A5086490803 @default.
• W4205742762 creator A5088773382 @default.
• W4205742762 creator A5089578403 @default.
• W4205742762 date "2022-01-01" @default.
• W4205742762 modified "2023-09-29" @default.
• W4205742762 title "RNAscope in situ hybridization and RT‐PCR for detection of SARS‐CoV‐2 in chilblain‐like lesions: A clinical, laboratory and histopathological study" @default.
• W4205742762 cites W1960895270 @default.
• W4205742762 cites W3001195213 @default.
• W4205742762 cites W3018949454 @default.
• W4205742762 cites W3020939730 @default.
• W4205742762 cites W3023677251 @default.
• W4205742762 cites W3023973583 @default.
• W4205742762 cites W3025852613 @default.
• W4205742762 cites W3031975311 @default.
• W4205742762 cites W3032222329 @default.
• W4205742762 cites W3036513241 @default.
• W4205742762 cites W3037583352 @default.
• W4205742762 cites W3037980078 @default.
• W4205742762 cites W3048883703 @default.
• W4205742762 cites W3083236403 @default.
• W4205742762 cites W3089724188 @default.
• W4205742762 cites W3093979943 @default.
• W4205742762 cites W3105642416 @default.
• W4205742762 cites W3107944255 @default.
• W4205742762 cites W3108054068 @default.
• W4205742762 cites W3108568475 @default.
• W4205742762 cites W3112601605 @default.
• W4205742762 cites W3121195730 @default.
• W4205742762 cites W3153597799 @default.
• W4205742762 cites W3173115214 @default.
• W4205742762 doi "https://doi.org/10.1111/pde.14903" @default.
• W4205742762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34989043" @default.
• W4205742762 hasPublicationYear "2022" @default.
• W4205742762 type Work @default.
• W4205742762 citedByCount "1" @default.
• W4205742762 countsByYear W42057427622022 @default.
• W4205742762 crossrefType "journal-article" @default.
• W4205742762 hasAuthorship W4205742762A5001655675 @default.
• W4205742762 hasAuthorship W4205742762A5012969542 @default.
• W4205742762 hasAuthorship W4205742762A5024677633 @default.
• W4205742762 hasAuthorship W4205742762A5043435667 @default.
• W4205742762 hasAuthorship W4205742762A5057447510 @default.
• W4205742762 hasAuthorship W4205742762A5063147525 @default.
• W4205742762 hasAuthorship W4205742762A5074410273 @default.
• W4205742762 hasAuthorship W4205742762A5075188736 @default.
• W4205742762 hasAuthorship W4205742762A5083335316 @default.
• W4205742762 hasAuthorship W4205742762A5086490803 @default.
• W4205742762 hasAuthorship W4205742762A5088773382 @default.
• W4205742762 hasAuthorship W4205742762A5089578403 @default.
• W4205742762 hasConcept C142724271 @default.
• W4205742762 hasConcept C159047783 @default.
• W4205742762 hasConcept C16005928 @default.
• W4205742762 hasConcept C2522874641 @default.
• W4205742762 hasConcept C2779630601 @default.
• W4205742762 hasConcept C71924100 @default.
• W4205742762 hasConceptScore W4205742762C142724271 @default.
• W4205742762 hasConceptScore W4205742762C159047783 @default.
• W4205742762 hasConceptScore W4205742762C16005928 @default.
• W4205742762 hasConceptScore W4205742762C2522874641 @default.
• W4205742762 hasConceptScore W4205742762C2779630601 @default.
• W4205742762 hasConceptScore W4205742762C71924100 @default.
• W4205742762 hasIssue "1" @default.
• W4205742762 hasLocation W42057427621 @default.
• W4205742762 hasLocation W42057427622 @default.
• W4205742762 hasOpenAccess W4205742762 @default.
• W4205742762 hasPrimaryLocation W42057427621 @default.
• W4205742762 hasRelatedWork W2000236737 @default.
• W4205742762 hasRelatedWork W2057260312 @default.
• W4205742762 hasRelatedWork W2128434532 @default.
• W4205742762 hasRelatedWork W2171409124 @default.
• W4205742762 hasRelatedWork W2278625985 @default.
• W4205742762 hasRelatedWork W2394381610 @default.
• W4205742762 hasRelatedWork W2596873895 @default.
• W4205742762 hasRelatedWork W2738981461 @default.
• W4205742762 hasRelatedWork W4234833016 @default.
• W4205742762 hasRelatedWork W4297184974 @default.
• W4205742762 hasVolume "39" @default.
• W4205742762 isParatext "false" @default.
• W4205742762 isRetracted "false" @default.
• W4205742762 workType "article" @default.