FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205761500> ?p ?o ?g. }

• W4205761500 abstract "Nerve growth factor-β (NGF) is critical for ovulation in the mammalian ovary and is luteotrophic when administered systemically to camelids and cattle. This study aimed to assess the direct effects of purified bovine NGF on steroidogenesis and angiogenic markers in the bovine pre-ovulatory follicle. Holstein heifers (n = 2) were synchronized with a standard protocol, and heifers with a preovulatory follicle (≥ 12 mm) had the ovary containing the dominant follicle removed via colpotomy. Pre-ovulatory follicles were dissected into 24 pieces containing theca and granulosa cells that were randomly allocated into culture media supplemented with either purified bovine NGF (100 ng/mL) or untreated (control) for 72 h. The supernatant media was harvested for quantification of progesterone, testosterone, and estradiol concentrations, whereas explants were subjected to mRNA analyses to assess expression of steroidogenic and angiogenic markers. Treatment of follicle wall pieces with NGF upregulated gene expression of steroidogenic enzyme HDS17B (P = 0.04) and increased testosterone production (P < 0.01). However, NGF treatment did not alter production of progesterone (P = 0.81) or estradiol (P = 0.14). Consistently, gene expression of steroidogenic enzymes responsible for producing these hormones (STAR, CYP11A1, HSD3B, CYP17A1, CYP19A1) were unaffected by NGF treatment (P ≥ 0.31). Treatment with NGF downregulated gene expression of the angiogenic enzyme FGF2 (P = 0.02) but did not alter PGES (P = 0.63), VEGFA (P = 0.44), and ESR1 (P = 0.77). Collectively, these results demonstrate that NGF from seminal plasma may interact directly on the theca and granulosa cells of the bovine pre-ovulatory follicle to stimulate testosterone production, which may be secondary to theca cell proliferation. Additionally, decreased FGF2 expression in NGF-treated follicle wall cells suggests hastened onset of follicle wall cellular remodeling that occurs during early luteal development." @default.
• W4205761500 created "2022-01-26" @default.
• W4205761500 creator A5011801528 @default.
• W4205761500 creator A5030790480 @default.
• W4205761500 creator A5037432034 @default.
• W4205761500 creator A5040949438 @default.
• W4205761500 creator A5081314358 @default.
• W4205761500 creator A5084189295 @default.
• W4205761500 creator A5087140986 @default.
• W4205761500 date "2022-01-17" @default.
• W4205761500 modified "2023-10-16" @default.
• W4205761500 title "Effects of Nerve Growth Factor-β From Bull Seminal Plasma on Steroidogenesis and Angiogenic Markers of the Bovine Pre-ovulatory Follicle Wall Cell Culture" @default.
• W4205761500 cites W1479055651 @default.
• W4205761500 cites W1967586250 @default.
• W4205761500 cites W1980527010 @default.
• W4205761500 cites W1989016953 @default.
• W4205761500 cites W1991176928 @default.
• W4205761500 cites W1993035190 @default.
• W4205761500 cites W1994718549 @default.
• W4205761500 cites W2003868685 @default.
• W4205761500 cites W2007444403 @default.
• W4205761500 cites W2009720517 @default.
• W4205761500 cites W2035446538 @default.
• W4205761500 cites W2039520953 @default.
• W4205761500 cites W2043625677 @default.
• W4205761500 cites W2044650837 @default.
• W4205761500 cites W2048319465 @default.
• W4205761500 cites W2051209291 @default.
• W4205761500 cites W2059155698 @default.
• W4205761500 cites W2063159660 @default.
• W4205761500 cites W2067652148 @default.
• W4205761500 cites W2071235117 @default.
• W4205761500 cites W2085128854 @default.
• W4205761500 cites W2093096968 @default.
• W4205761500 cites W2103023862 @default.
• W4205761500 cites W2107277218 @default.
• W4205761500 cites W2107640907 @default.
• W4205761500 cites W2122588580 @default.
• W4205761500 cites W2123751937 @default.
• W4205761500 cites W2145748723 @default.
• W4205761500 cites W2154048516 @default.
• W4205761500 cites W2157634837 @default.
• W4205761500 cites W2161023153 @default.
• W4205761500 cites W2164215458 @default.
• W4205761500 cites W2461181079 @default.
• W4205761500 cites W2477456541 @default.
• W4205761500 cites W2761071250 @default.
• W4205761500 cites W2891682937 @default.
• W4205761500 doi "https://doi.org/10.3389/fvets.2021.786480" @default.
• W4205761500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35111838" @default.
• W4205761500 hasPublicationYear "2022" @default.
• W4205761500 type Work @default.
• W4205761500 citedByCount "4" @default.
• W4205761500 countsByYear W42057615002022 @default.
• W4205761500 countsByYear W42057615002023 @default.
• W4205761500 crossrefType "journal-article" @default.
• W4205761500 hasAuthorship W4205761500A5011801528 @default.
• W4205761500 hasAuthorship W4205761500A5030790480 @default.
• W4205761500 hasAuthorship W4205761500A5037432034 @default.
• W4205761500 hasAuthorship W4205761500A5040949438 @default.
• W4205761500 hasAuthorship W4205761500A5081314358 @default.
• W4205761500 hasAuthorship W4205761500A5084189295 @default.
• W4205761500 hasAuthorship W4205761500A5087140986 @default.
• W4205761500 hasBestOaLocation W42057615001 @default.
• W4205761500 hasConcept C102570824 @default.
• W4205761500 hasConcept C104317684 @default.
• W4205761500 hasConcept C126322002 @default.
• W4205761500 hasConcept C134018914 @default.
• W4205761500 hasConcept C150194340 @default.
• W4205761500 hasConcept C16685009 @default.
• W4205761500 hasConcept C170493617 @default.
• W4205761500 hasConcept C175805485 @default.
• W4205761500 hasConcept C196843134 @default.
• W4205761500 hasConcept C2776986892 @default.
• W4205761500 hasConcept C2777203538 @default.
• W4205761500 hasConcept C2777702977 @default.
• W4205761500 hasConcept C2778324911 @default.
• W4205761500 hasConcept C2778423431 @default.
• W4205761500 hasConcept C2779279991 @default.
• W4205761500 hasConcept C2779670467 @default.
• W4205761500 hasConcept C2780536345 @default.
• W4205761500 hasConcept C526171541 @default.
• W4205761500 hasConcept C5512455 @default.
• W4205761500 hasConcept C55493867 @default.
• W4205761500 hasConcept C62231903 @default.
• W4205761500 hasConcept C71315377 @default.
• W4205761500 hasConcept C71924100 @default.
• W4205761500 hasConcept C80446465 @default.
• W4205761500 hasConcept C86803240 @default.
• W4205761500 hasConcept C87073359 @default.
• W4205761500 hasConcept C95444343 @default.
• W4205761500 hasConceptScore W4205761500C102570824 @default.
• W4205761500 hasConceptScore W4205761500C104317684 @default.
• W4205761500 hasConceptScore W4205761500C126322002 @default.
• W4205761500 hasConceptScore W4205761500C134018914 @default.
• W4205761500 hasConceptScore W4205761500C150194340 @default.
• W4205761500 hasConceptScore W4205761500C16685009 @default.
• W4205761500 hasConceptScore W4205761500C170493617 @default.
• W4205761500 hasConceptScore W4205761500C175805485 @default.
• W4205761500 hasConceptScore W4205761500C196843134 @default.

• next