Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205770978> ?p ?o ?g. }
- W4205770978 endingPage "31" @default.
- W4205770978 startingPage "31" @default.
- W4205770978 abstract "Malignant gliomas are associated with extremely poor clinical outcomes in both humans and dogs, and novel therapies are needed. Glioma-bearing canine patients may serve as promising preclinical models for human therapies, including complementary medicine. The objective of this study was to evaluate the effects of mistletoe extract (Viscum album) alone and in combination with mebendazole in an in vitro model of canine high-grade astrocytoma using the cell line SDT-3G. SDT-3G cells were exposed to a range of concentrations of mistletoe extract alone to obtain an IC50. In separate experiments, cells were exposed to mebendazole at a previously determined IC50 (0.03 µM) alone or in conjunction with varying concentrations of mistletoe extract to determine the additive effects. The IC50 for mistletoe alone was 5.644 ± 0.09 SD μg/mL. The addition of mistletoe at 5 μg/mL to mebendazole at 0.03 µM led to increased cell death compared to what would be expected for each drug separately. The cytotoxicity of mistletoe in vitro and its additive effect with mebendazole support future expanded in vitro and in vivo studies in dogs and supply early evidence that this may be a useful adjunct therapeutic agent for use in glioma-bearing dogs. To the authors' knowledge, this is the first published report of Viscum album extract in canine glioma." @default.
- W4205770978 created "2022-01-26" @default.
- W4205770978 creator A5014457670 @default.
- W4205770978 creator A5020544156 @default.
- W4205770978 creator A5056763447 @default.
- W4205770978 date "2022-01-15" @default.
- W4205770978 modified "2023-09-26" @default.
- W4205770978 title "European Mistletoe (Viscum album) Extract Is Cytotoxic to Canine High-Grade Astrocytoma Cells In Vitro and Has Additive Effects with Mebendazole" @default.
- W4205770978 cites W1544194316 @default.
- W4205770978 cites W1553534857 @default.
- W4205770978 cites W1905089437 @default.
- W4205770978 cites W1967034772 @default.
- W4205770978 cites W1968601707 @default.
- W4205770978 cites W1974542892 @default.
- W4205770978 cites W1979803685 @default.
- W4205770978 cites W1983495657 @default.
- W4205770978 cites W1992179207 @default.
- W4205770978 cites W2000000541 @default.
- W4205770978 cites W2006781128 @default.
- W4205770978 cites W2013219708 @default.
- W4205770978 cites W2019482220 @default.
- W4205770978 cites W2022014999 @default.
- W4205770978 cites W2040277279 @default.
- W4205770978 cites W2041066887 @default.
- W4205770978 cites W2051588629 @default.
- W4205770978 cites W2055962749 @default.
- W4205770978 cites W2062166509 @default.
- W4205770978 cites W2064288062 @default.
- W4205770978 cites W2064349256 @default.
- W4205770978 cites W2065715875 @default.
- W4205770978 cites W2069027822 @default.
- W4205770978 cites W2082914105 @default.
- W4205770978 cites W2090078367 @default.
- W4205770978 cites W2101893195 @default.
- W4205770978 cites W2113920410 @default.
- W4205770978 cites W2115862526 @default.
- W4205770978 cites W2120071860 @default.
- W4205770978 cites W2131981377 @default.
- W4205770978 cites W2133833211 @default.
- W4205770978 cites W2135428178 @default.
- W4205770978 cites W2142115420 @default.
- W4205770978 cites W2151794458 @default.
- W4205770978 cites W2158649478 @default.
- W4205770978 cites W2164088832 @default.
- W4205770978 cites W2181074044 @default.
- W4205770978 cites W2294528203 @default.
- W4205770978 cites W2315279202 @default.
- W4205770978 cites W2393820387 @default.
- W4205770978 cites W2411263727 @default.
- W4205770978 cites W2422973035 @default.
- W4205770978 cites W2442532513 @default.
- W4205770978 cites W2507591416 @default.
- W4205770978 cites W2648579953 @default.
- W4205770978 cites W2771145381 @default.
- W4205770978 cites W2772160966 @default.
- W4205770978 cites W2890902697 @default.
- W4205770978 cites W3033556583 @default.
- W4205770978 cites W4212949515 @default.
- W4205770978 doi "https://doi.org/10.3390/vetsci9010031" @default.
- W4205770978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35051115" @default.
- W4205770978 hasPublicationYear "2022" @default.
- W4205770978 type Work @default.
- W4205770978 citedByCount "1" @default.
- W4205770978 countsByYear W42057709782023 @default.
- W4205770978 crossrefType "journal-article" @default.
- W4205770978 hasAuthorship W4205770978A5014457670 @default.
- W4205770978 hasAuthorship W4205770978A5020544156 @default.
- W4205770978 hasAuthorship W4205770978A5056763447 @default.
- W4205770978 hasBestOaLocation W42057709781 @default.
- W4205770978 hasConcept C109316439 @default.
- W4205770978 hasConcept C150903083 @default.
- W4205770978 hasConcept C154317977 @default.
- W4205770978 hasConcept C18903297 @default.
- W4205770978 hasConcept C202751555 @default.
- W4205770978 hasConcept C207001950 @default.
- W4205770978 hasConcept C2778227246 @default.
- W4205770978 hasConcept C2779061029 @default.
- W4205770978 hasConcept C2780306569 @default.
- W4205770978 hasConcept C502942594 @default.
- W4205770978 hasConcept C55493867 @default.
- W4205770978 hasConcept C556039675 @default.
- W4205770978 hasConcept C71924100 @default.
- W4205770978 hasConcept C86803240 @default.
- W4205770978 hasConcept C98274493 @default.
- W4205770978 hasConceptScore W4205770978C109316439 @default.
- W4205770978 hasConceptScore W4205770978C150903083 @default.
- W4205770978 hasConceptScore W4205770978C154317977 @default.
- W4205770978 hasConceptScore W4205770978C18903297 @default.
- W4205770978 hasConceptScore W4205770978C202751555 @default.
- W4205770978 hasConceptScore W4205770978C207001950 @default.
- W4205770978 hasConceptScore W4205770978C2778227246 @default.
- W4205770978 hasConceptScore W4205770978C2779061029 @default.
- W4205770978 hasConceptScore W4205770978C2780306569 @default.
- W4205770978 hasConceptScore W4205770978C502942594 @default.
- W4205770978 hasConceptScore W4205770978C55493867 @default.
- W4205770978 hasConceptScore W4205770978C556039675 @default.
- W4205770978 hasConceptScore W4205770978C71924100 @default.
- W4205770978 hasConceptScore W4205770978C86803240 @default.