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- W4205775086 abstract "Dendritic cell (DC) maturation and migration are events critical for the initiation of immune responses. After encountering pathogens, DCs upregulate the expression of costimulatory molecules and subsequently migrate to secondary lymphoid organs. Calcium (Ca(2+)) entry governs the functions of many hematopoietic cell types, but the role of Ca(2+) entry in DC biology remains unclear. Here we report that the Ca(2+)-activated nonselective cation channel TRPM4 was expressed in and controlled the Ca(2+) homeostasis of mouse DCs. The absence of TRPM4, which elicited Ca(2+) overload, did not influence DC maturation but did considerably impair chemokine-dependent DC migration. Our results establish TRPM4-regulated Ca(2+) homeostasis as crucial for DC mobility but not maturation and emphasize that DC maturation and migration are independently regulated. PMID: 18758465 Funding information This work was supported by: NIAID NIH HHS, United States Grant ID: R01 AI046734-08 NIAID NIH HHS, United States Grant ID: R01 AI046734-07 NIAID NIH HHS, United States Grant ID: R01 AI046734-06 NIAID NIH HHS, United States Grant ID: R01 AI046734" @default.
- W4205775086 created "2022-01-25" @default.
- W4205775086 creator A5071455949 @default.
- W4205775086 date "2008-12-18" @default.
- W4205775086 modified "2023-09-26" @default.
- W4205775086 title "Faculty Opinions recommendation of The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells." @default.
- W4205775086 doi "https://doi.org/10.3410/f.1137939.596017" @default.
- W4205775086 hasPublicationYear "2008" @default.
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