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• W4205789336 abstract "Sensory neurons are responsible for the generation and transmission of nociceptive signals from the periphery to the central nervous system. They encompass a broadly heterogeneous population of highly specialized neurons. The understanding of the molecular choreography of individual subpopulations is essential to understand physiological and pathological pain states. Recently, it became evident that species differences limit transferability of research findings between human and rodents in pain research. Thus, it is necessary to systematically compare and categorize the electrophysiological data gained from human and rodent dorsal root ganglia neurons (DRGs). In this systematic review, we condense the available electrophysiological data defining subidentities in human and rat DRGs. A systematic search on PUBMED yielded 30 studies on rat and 3 studies on human sensory neurons. Defined outcome parameters included current clamp, voltage clamp, cell morphology, pharmacological readouts, and immune reactivity parameters. We compare evidence gathered for outcome markers to define subgroups, offer electrophysiological parameters for the definition of neuronal subtypes, and give a framework for the transferability of electrophysiological findings between species. A semiquantitative analysis revealed that for rat DRGs, there is an overarching consensus between studies that C-fiber linked sensory neurons display a lower action potential threshold, higher input resistance, a larger action potential overshoot, and a longer afterhyperpolarization duration compared to other sensory neurons. They are also more likely to display an infliction point in the falling phase of the action potential. This systematic review points out the need of more electrophysiological studies on human sensory neurons." @default.
• W4205789336 created "2022-01-25" @default.
• W4205789336 creator A5015297897 @default.
• W4205789336 creator A5056610922 @default.
• W4205789336 date "2022-01-15" @default.
• W4205789336 modified "2023-10-14" @default.
• W4205789336 title "Functional subgroups of rat and human sensory neurons: a systematic review of electrophysiological properties" @default.
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• W4205789336 doi "https://doi.org/10.1007/s00424-021-02656-6" @default.
• W4205789336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35031856" @default.
• W4205789336 hasPublicationYear "2022" @default.
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