Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205790948> ?p ?o ?g. }
- W4205790948 abstract "Cardiovascular diseases, especially atherosclerosis, are the leading cause of human mortality in Indonesia. Ipomoea batatas (L.) is a food plant used in Indonesian traditional medicine to treat cardiovascular diseases and related conditions. We assessed the anti-atherosclerotic activity of the aqueous extract of I. batatas leaves in a rat model of high-fat diet-induced atherosclerosis and its mechanism.The presence of amino acid content in the I. batatas L. purple variant was determined by liquid chromatography high-resolution mass spectrometry (LC-HRMS). Thirty male Wistar rats were divided into five groups (n=6/group), i.e., standard diet group (SD), high-fat diet group (HF), and HF plus I. batatas L. extracts orally (625; 1,250; or 2,500 mg/kg) groups. The numbers of macrophages and aortic wall thickness were analyzed histologically. Immunohistochemical analyses were performed to assess foam cells-oxidized low-density lipoprotein (oxLDL), endothelial nitric oxide synthase (eNOS), and vascular endothelial growth factor (VEGF) expression in the aorta.LC-HRMS analysis showed nine amino acid content were identified from I. batatas L. In vivo study revealed that oral administration of I. batatas L. leaf extract alleviated foam cells-oxLDL formation and aortic wall thickness caused by high-fat diet atherosclerosis rats. Further, I. batatas L. leaf extract promoted the number of macrophages and modulated VEGF and eNOS expression in the aorta.I. batatas L. leaf extract shows a positive anti-atherosclerosis effect. Furthermore, the mechanism may promote the macrophages, eNOS, VEGF expressions, and inhibition of foam cells-oxLDL formation and aortic wall thickness with the best dosage at 2,500 mg/kg. This could represent a novel approach to prevent cardiovascular diseases." @default.
- W4205790948 created "2022-01-26" @default.
- W4205790948 creator A5031542784 @default.
- W4205790948 creator A5063812781 @default.
- W4205790948 creator A5070345714 @default.
- W4205790948 creator A5086168813 @default.
- W4205790948 date "2022-01-06" @default.
- W4205790948 modified "2023-09-28" @default.
- W4205790948 title "Anti-atherosclerotic activity of aqueous extract of Ipomoea batatas (L.) leaves in high-fat diet-induced atherosclerosis model rats" @default.
- W4205790948 cites W1507916171 @default.
- W4205790948 cites W1880542775 @default.
- W4205790948 cites W1949072443 @default.
- W4205790948 cites W1970017835 @default.
- W4205790948 cites W1974081986 @default.
- W4205790948 cites W1974834280 @default.
- W4205790948 cites W1991741643 @default.
- W4205790948 cites W1994491528 @default.
- W4205790948 cites W1997023449 @default.
- W4205790948 cites W2003605294 @default.
- W4205790948 cites W2003923040 @default.
- W4205790948 cites W2004820940 @default.
- W4205790948 cites W2021322411 @default.
- W4205790948 cites W2045892982 @default.
- W4205790948 cites W2045982598 @default.
- W4205790948 cites W2057687781 @default.
- W4205790948 cites W2094629035 @default.
- W4205790948 cites W2099398050 @default.
- W4205790948 cites W2109074735 @default.
- W4205790948 cites W2119871913 @default.
- W4205790948 cites W2124376174 @default.
- W4205790948 cites W2134382614 @default.
- W4205790948 cites W2137475525 @default.
- W4205790948 cites W2137698038 @default.
- W4205790948 cites W2146917818 @default.
- W4205790948 cites W2149968000 @default.
- W4205790948 cites W2150616706 @default.
- W4205790948 cites W2156013098 @default.
- W4205790948 cites W2217809975 @default.
- W4205790948 cites W2336309832 @default.
- W4205790948 cites W2338544094 @default.
- W4205790948 cites W2515203770 @default.
- W4205790948 cites W2561564221 @default.
- W4205790948 cites W2585441851 @default.
- W4205790948 cites W2604650656 @default.
- W4205790948 cites W2766451938 @default.
- W4205790948 cites W2790782441 @default.
- W4205790948 cites W2804155717 @default.
- W4205790948 cites W2900255600 @default.
- W4205790948 cites W2909682173 @default.
- W4205790948 cites W2972821757 @default.
- W4205790948 cites W2980339904 @default.
- W4205790948 cites W2985630013 @default.
- W4205790948 cites W3004079464 @default.
- W4205790948 cites W3012927814 @default.
- W4205790948 cites W3085515718 @default.
- W4205790948 cites W3109275124 @default.
- W4205790948 cites W3112651644 @default.
- W4205790948 cites W3133867180 @default.
- W4205790948 cites W3151892493 @default.
- W4205790948 cites W3169910061 @default.
- W4205790948 cites W3180544260 @default.
- W4205790948 doi "https://doi.org/10.1515/jbcpp-2021-0080" @default.
- W4205790948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34986543" @default.
- W4205790948 hasPublicationYear "2022" @default.
- W4205790948 type Work @default.
- W4205790948 citedByCount "1" @default.
- W4205790948 countsByYear W42057909482022 @default.
- W4205790948 crossrefType "journal-article" @default.
- W4205790948 hasAuthorship W4205790948A5031542784 @default.
- W4205790948 hasAuthorship W4205790948A5063812781 @default.
- W4205790948 hasAuthorship W4205790948A5070345714 @default.
- W4205790948 hasAuthorship W4205790948A5086168813 @default.
- W4205790948 hasConcept C126322002 @default.
- W4205790948 hasConcept C134018914 @default.
- W4205790948 hasConcept C185592680 @default.
- W4205790948 hasConcept C2777622882 @default.
- W4205790948 hasConcept C2777895019 @default.
- W4205790948 hasConcept C2778163477 @default.
- W4205790948 hasConcept C2778326061 @default.
- W4205790948 hasConcept C2778728632 @default.
- W4205790948 hasConcept C2779980429 @default.
- W4205790948 hasConcept C2780072125 @default.
- W4205790948 hasConcept C31903555 @default.
- W4205790948 hasConcept C519581460 @default.
- W4205790948 hasConcept C55493867 @default.
- W4205790948 hasConcept C59822182 @default.
- W4205790948 hasConcept C71924100 @default.
- W4205790948 hasConcept C86803240 @default.
- W4205790948 hasConceptScore W4205790948C126322002 @default.
- W4205790948 hasConceptScore W4205790948C134018914 @default.
- W4205790948 hasConceptScore W4205790948C185592680 @default.
- W4205790948 hasConceptScore W4205790948C2777622882 @default.
- W4205790948 hasConceptScore W4205790948C2777895019 @default.
- W4205790948 hasConceptScore W4205790948C2778163477 @default.
- W4205790948 hasConceptScore W4205790948C2778326061 @default.
- W4205790948 hasConceptScore W4205790948C2778728632 @default.
- W4205790948 hasConceptScore W4205790948C2779980429 @default.
- W4205790948 hasConceptScore W4205790948C2780072125 @default.
- W4205790948 hasConceptScore W4205790948C31903555 @default.
- W4205790948 hasConceptScore W4205790948C519581460 @default.