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• W4205800385 endingPage "151956" @default.
• W4205800385 startingPage "151956" @default.
• W4205800385 abstract "Behçet's disease (BD) is an auto-inflammatory disease, primarily characterized by recurrent painful mucocutaneous ulcerations.A literature search was performed to write a narrative review into the pathogenesis and current treatment options of BD.The pathogenesis of BD remains to be elucidated, but is considered a genetically primed disease in which an external trigger causes immune activation resulting in inflammatory symptoms. GWAS data show an association between multiple genetic polymorphisms (HLA-B51, ERAP1, IL10 and IL23R-IL12RB2) and increased susceptibility to BD. Bacteria as streptococci, an unbalanced microbiome or molecular mimicry trigger the inflammation in BD. Increased production or responsiveness of pro-inflammatory components of the innate immune response (TLR, neutrophils, NK-cells or γδ T-cells) to these triggers may be a crucial step in the pathogenesis of BD. Additionally to an increased autoinflammatory response there is evidence of a dysregulated adaptive immune system, with a disturbed Th1/Th2 balance, expansion of Th17 cells and possibly a decrease in regulatory T cells, resulting in a surplus in pro-inflammatory cytokines. The inflammation causes a typical clinical phenotype including orogenital ulcerations, uveitis and skin lesions. Treatment is aimed at the aberrations found in the innate (neutrophils and γδ-T cells) and adaptive immune system (TNF-α, INF-γ, IL-1), directed at organ involvement and individualized based on patient characteristics.We presented an extensive review into the pathogenesis and treatment options of BD." @default.
• W4205800385 created "2022-01-25" @default.
• W4205800385 creator A5013309397 @default.
• W4205800385 creator A5016878392 @default.
• W4205800385 creator A5062554397 @default.
• W4205800385 date "2022-02-01" @default.
• W4205800385 modified "2023-10-06" @default.
• W4205800385 title "Immunopathogenesis of Behçet's disease and treatment modalities" @default.
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