FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205800804> ?p ?o ?g. }

• W4205800804 endingPage "153095" @default.
• W4205800804 startingPage "153095" @default.
• W4205800804 abstract "Recent studies have shown guanylurea (GUA) alters the growth and development of fish, induces oxidative stress, and disrupts the levels and expression of several genes, metabolites, and proteins related to the overall fitness of fish. Nonetheless, up to date, no study has assessed the potential neurotoxic effects that GUA may induce in non-target organisms. To fill the current knowledge gaps about the effects of this metabolite in the central nervous system of fish, we aimed to determine whether or not environmentally relevant concentrations of this metabolite may disrupt the behavior, redox status, AChE activity in Danio rerio adults. In addition, we also meant to assess if 25, 50, and 200 μg/L of GUA can alter the expression of several antioxidant defenses-, apoptosis-, AMPK pathway-, and neuronal communication-related genes in the brain of fish exposed for four months to GUA. Our results demonstrated that chronic exposure to GUA altered the swimming behavior of D. rerio, as fish remained more time frozen and traveled less distance in the tank compared to the control group. Moreover, this metabolite significantly increased the levels of oxidative damage biomarkers and inhibited the activity of acetylcholinesterase of fish in a concentration-dependent manner. Concerning gene expression, environmentally relevant concentrations of GUA downregulated the expression GRID2IP, PCDH17, and PCDH19, but upregulated Nrf1, Nrf2, p53, BAX, CASP3, PRKAA1, PRKAA2, and APP in fish after four months of exposure. Collectively, we can conclude that GUA may alter the homeostasis of several essential brain biomarkers, generating anxiety-like behavior in fish." @default.
• W4205800804 created "2022-01-26" @default.
• W4205800804 creator A5003775743 @default.
• W4205800804 creator A5032812469 @default.
• W4205800804 creator A5037865959 @default.
• W4205800804 creator A5048738944 @default.
• W4205800804 creator A5070457304 @default.
• W4205800804 creator A5070796563 @default.
• W4205800804 creator A5086402904 @default.
• W4205800804 date "2022-05-01" @default.
• W4205800804 modified "2023-10-10" @default.
• W4205800804 title "Chronic exposure to environmentally relevant concentrations of guanylurea induces neurotoxicity of Danio rerio adults" @default.
• W4205800804 cites W1000208362 @default.
• W4205800804 cites W1499080786 @default.
• W4205800804 cites W1508162082 @default.
• W4205800804 cites W1511202363 @default.
• W4205800804 cites W1515746007 @default.
• W4205800804 cites W1557712018 @default.
• W4205800804 cites W1590457525 @default.
• W4205800804 cites W1750690213 @default.
• W4205800804 cites W1971048984 @default.
• W4205800804 cites W1988821503 @default.
• W4205800804 cites W1996822183 @default.
• W4205800804 cites W2006679853 @default.
• W4205800804 cites W2022535843 @default.
• W4205800804 cites W2027015623 @default.
• W4205800804 cites W2055219455 @default.
• W4205800804 cites W2061333433 @default.
• W4205800804 cites W2077852011 @default.
• W4205800804 cites W2079749054 @default.
• W4205800804 cites W2094107463 @default.
• W4205800804 cites W2094125103 @default.
• W4205800804 cites W2108058238 @default.
• W4205800804 cites W2130769499 @default.
• W4205800804 cites W2143512060 @default.
• W4205800804 cites W2217461794 @default.
• W4205800804 cites W2320228393 @default.
• W4205800804 cites W2329336071 @default.
• W4205800804 cites W2491034915 @default.
• W4205800804 cites W2557513796 @default.
• W4205800804 cites W2604318154 @default.
• W4205800804 cites W2620372498 @default.
• W4205800804 cites W2732828256 @default.
• W4205800804 cites W2747084217 @default.
• W4205800804 cites W2756314208 @default.
• W4205800804 cites W2760088574 @default.
• W4205800804 cites W2789295379 @default.
• W4205800804 cites W2791113187 @default.
• W4205800804 cites W2791544604 @default.
• W4205800804 cites W2804758746 @default.
• W4205800804 cites W2887248232 @default.
• W4205800804 cites W2896647652 @default.
• W4205800804 cites W2897969206 @default.
• W4205800804 cites W2899678590 @default.
• W4205800804 cites W2905716177 @default.
• W4205800804 cites W2920633228 @default.
• W4205800804 cites W2945516613 @default.
• W4205800804 cites W2963328038 @default.
• W4205800804 cites W2971514915 @default.
• W4205800804 cites W2977108165 @default.
• W4205800804 cites W2989316097 @default.
• W4205800804 cites W2993032962 @default.
• W4205800804 cites W3017907928 @default.
• W4205800804 cites W3019405177 @default.
• W4205800804 cites W3036246005 @default.
• W4205800804 cites W3043206567 @default.
• W4205800804 cites W3082832471 @default.
• W4205800804 cites W3107536532 @default.
• W4205800804 cites W3110909094 @default.
• W4205800804 cites W3126728880 @default.
• W4205800804 cites W3175411618 @default.
• W4205800804 cites W3179942245 @default.
• W4205800804 cites W3191681572 @default.
• W4205800804 cites W3205324412 @default.
• W4205800804 cites W4293247451 @default.
• W4205800804 doi "https://doi.org/10.1016/j.scitotenv.2022.153095" @default.
• W4205800804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35038519" @default.
• W4205800804 hasPublicationYear "2022" @default.
• W4205800804 type Work @default.
• W4205800804 citedByCount "14" @default.
• W4205800804 countsByYear W42058008042022 @default.
• W4205800804 countsByYear W42058008042023 @default.
• W4205800804 crossrefType "journal-article" @default.
• W4205800804 hasAuthorship W4205800804A5003775743 @default.
• W4205800804 hasAuthorship W4205800804A5032812469 @default.
• W4205800804 hasAuthorship W4205800804A5037865959 @default.
• W4205800804 hasAuthorship W4205800804A5048738944 @default.
• W4205800804 hasAuthorship W4205800804A5070457304 @default.
• W4205800804 hasAuthorship W4205800804A5070796563 @default.
• W4205800804 hasAuthorship W4205800804A5086402904 @default.
• W4205800804 hasConcept C104317684 @default.
• W4205800804 hasConcept C178790620 @default.
• W4205800804 hasConcept C181199279 @default.
• W4205800804 hasConcept C185592680 @default.
• W4205800804 hasConcept C2776151105 @default.
• W4205800804 hasConcept C2776878037 @default.
• W4205800804 hasConcept C2777477808 @default.
• W4205800804 hasConcept C2778004101 @default.

• next