FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205804914> ?p ?o ?g. }

• W4205804914 endingPage "PR02" @default.
• W4205804914 startingPage "PR02" @default.
• W4205804914 abstract "Abstract Cancer immunotherapies, specifically checkpoint blockade therapies, are extremely successful at treating subpopulations of specific cancers long term. The idea is to disrupt the negative regulation of T cells and restore cytotoxic abilities allowing killing of the cancer cells and formation of memory T cells. This provides immunity that has the potential to last a lifetime against recurring cancer. One major limitation to checkpoint blockade is that it is has limited response rate, one theory as to why this is the case, is that there are multiple non-redundant pathways of regulation of T cell activation. In response to the heterogeneous and suppressive tumor microenvironment, the T cell may present many immune checkpoint proteins simultaneously. Thus, it is important to study the immune checkpoint proteins in context of one another with the goal of developing combinatorial therapies. Here we present the co-expression of two immune checkpoint proteins and how their co-expression results in altered metabolism in cytotoxic T cells. V-domain Immunoglobulin Suppressor of T-cell Activation (VISTA) is a protein with many roles that are still largely undefined across a variety of immune cells in which it is expressed. T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) is a bi-directional receptor that has been reported to have a suppressive intrinsic T cell role when probed with agonistic antibody, the mechanism is yet to be defined. Our data suggest that VISTA and TIGIT are co-expressed in varying amounts across a variety of murine and human cancers and that this co-expression may contribute to an altered metabolic phenotype. Our results give insight to the contribution of multiple checkpoint proteins to the state of the cytotoxic T cell and declare the importance of studying these proteins in context of one another. This data reaffirm the need to study non-redundant pathways of T cell suppression with the goal of developing inhibitors that are more broadly applicable to restore anti-tumor immunity and increase patient survival. Citation Format: Cassandra Gilmour, Seong-Keun (Steve) Yoo, Timothy Chan, Lily Wang. The co-expression of VISTA and TIGIT on cytotoxic T cells defines subpopulation with altered immunometabolism [abstract]. In: Abstracts: AACR Virtual Special Conference: Tumor Immunology and Immunotherapy; 2021 Oct 5-6. Philadelphia (PA): AACR; Cancer Immunol Res 2022;10(1 Suppl):Abstract nr PR02." @default.
• W4205804914 created "2022-01-26" @default.
• W4205804914 creator A5020503630 @default.
• W4205804914 creator A5065838176 @default.
• W4205804914 creator A5066893251 @default.
• W4205804914 creator A5080223712 @default.
• W4205804914 date "2022-01-01" @default.
• W4205804914 modified "2023-10-06" @default.
• W4205804914 title "Abstract PR02: The co-expression of VISTA and TIGIT on cytotoxic T cells defines subpopulation with altered immunometabolism" @default.
• W4205804914 doi "https://doi.org/10.1158/2326-6074.tumimm21-pr02" @default.
• W4205804914 hasPublicationYear "2022" @default.
• W4205804914 type Work @default.
• W4205804914 citedByCount "0" @default.
• W4205804914 crossrefType "journal-article" @default.
• W4205804914 hasAuthorship W4205804914A5020503630 @default.
• W4205804914 hasAuthorship W4205804914A5065838176 @default.
• W4205804914 hasAuthorship W4205804914A5066893251 @default.
• W4205804914 hasAuthorship W4205804914A5080223712 @default.
• W4205804914 hasConcept C151730666 @default.
• W4205804914 hasConcept C154317977 @default.
• W4205804914 hasConcept C159654299 @default.
• W4205804914 hasConcept C202751555 @default.
• W4205804914 hasConcept C203014093 @default.
• W4205804914 hasConcept C2776090121 @default.
• W4205804914 hasConcept C2776107976 @default.
• W4205804914 hasConcept C2777701055 @default.
• W4205804914 hasConcept C2779118045 @default.
• W4205804914 hasConcept C2779343474 @default.
• W4205804914 hasConcept C2780674031 @default.
• W4205804914 hasConcept C2780851360 @default.
• W4205804914 hasConcept C502942594 @default.
• W4205804914 hasConcept C55493867 @default.
• W4205804914 hasConcept C86803240 @default.
• W4205804914 hasConcept C8891405 @default.
• W4205804914 hasConcept C95444343 @default.
• W4205804914 hasConceptScore W4205804914C151730666 @default.
• W4205804914 hasConceptScore W4205804914C154317977 @default.
• W4205804914 hasConceptScore W4205804914C159654299 @default.
• W4205804914 hasConceptScore W4205804914C202751555 @default.
• W4205804914 hasConceptScore W4205804914C203014093 @default.
• W4205804914 hasConceptScore W4205804914C2776090121 @default.
• W4205804914 hasConceptScore W4205804914C2776107976 @default.
• W4205804914 hasConceptScore W4205804914C2777701055 @default.
• W4205804914 hasConceptScore W4205804914C2779118045 @default.
• W4205804914 hasConceptScore W4205804914C2779343474 @default.
• W4205804914 hasConceptScore W4205804914C2780674031 @default.
• W4205804914 hasConceptScore W4205804914C2780851360 @default.
• W4205804914 hasConceptScore W4205804914C502942594 @default.
• W4205804914 hasConceptScore W4205804914C55493867 @default.
• W4205804914 hasConceptScore W4205804914C86803240 @default.
• W4205804914 hasConceptScore W4205804914C8891405 @default.
• W4205804914 hasConceptScore W4205804914C95444343 @default.
• W4205804914 hasIssue "1_Supplement" @default.
• W4205804914 hasLocation W42058049141 @default.
• W4205804914 hasOpenAccess W4205804914 @default.
• W4205804914 hasPrimaryLocation W42058049141 @default.
• W4205804914 hasRelatedWork W2079588331 @default.
• W4205804914 hasRelatedWork W2112727616 @default.
• W4205804914 hasRelatedWork W2592785733 @default.
• W4205804914 hasRelatedWork W2898485571 @default.
• W4205804914 hasRelatedWork W3197815049 @default.
• W4205804914 hasRelatedWork W3204309362 @default.
• W4205804914 hasRelatedWork W3211450793 @default.
• W4205804914 hasRelatedWork W4200022043 @default.
• W4205804914 hasRelatedWork W4220675202 @default.
• W4205804914 hasRelatedWork W4313385114 @default.
• W4205804914 hasVolume "10" @default.
• W4205804914 isParatext "false" @default.
• W4205804914 isRetracted "false" @default.
• W4205804914 workType "article" @default.