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• W4205857029 abstract "Abstract The cell-free transcriptome in amniotic fluid (AF) has been shown to be informative of physiologic and pathologic processes in pregnancy; however, the change in AF proteome with gestational age has mostly been studied by targeted approaches. The objective of this study was to describe the gestational age-dependent changes in the AF proteome during normal pregnancy by using an omics platform. The abundance of 1310 proteins was measured on a high-throughput aptamer-based proteomics platform in AF samples collected from women during midtrimester (16–24 weeks of gestation, n = 15) and at term without labor (37–42 weeks of gestation, n = 13). Only pregnancies without obstetrical complications were included in the study. Almost 25% (320) of AF proteins significantly changed in abundance between the midtrimester and term gestation. Of these, 154 (48.1%) proteins increased, and 166 (51.9%) decreased in abundance at term compared to midtrimester. Tissue-specific signatures of the trachea, salivary glands, brain regions, and immune system were increased while those of the gestational tissues (uterus, placenta, and ovary), cardiac myocytes, and fetal liver were decreased at term compared to midtrimester. The changes in AF protein abundance were correlated with those previously reported in the cell-free AF transcriptome. Intersecting gestational age-modulated AF proteins and their corresponding mRNAs previously reported in the maternal blood identified neutrophil-related protein/mRNA pairs that were modulated in the same direction. The first study to utilize an aptamer-based assay to profile the AF proteome modulation with gestational age, it reveals that almost one-quarter of the proteins are modulated as gestation advances, which is more than twice the fraction of altered plasma proteins (~ 10%). The results reported herein have implications for future studies focused on discovering biomarkers to predict, monitor, and diagnose obstetrical diseases." @default.
• W4205857029 created "2022-01-26" @default.
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• W4205857029 date "2022-01-12" @default.
• W4205857029 modified "2023-10-18" @default.
• W4205857029 title "The amniotic fluid proteome changes with gestational age in normal pregnancy: a cross-sectional study" @default.
• W4205857029 cites W1504600926 @default.
• W4205857029 cites W1538399233 @default.
• W4205857029 cites W1893553316 @default.
• W4205857029 cites W1963481111 @default.
• W4205857029 cites W1965519079 @default.
• W4205857029 cites W1966327575 @default.
• W4205857029 cites W1969405385 @default.
• W4205857029 cites W1969717580 @default.
• W4205857029 cites W1972952097 @default.
• W4205857029 cites W1974562359 @default.
• W4205857029 cites W1982042298 @default.
• W4205857029 cites W1983621089 @default.
• W4205857029 cites W1983727861 @default.
• W4205857029 cites W1989879161 @default.
• W4205857029 cites W1995439030 @default.
• W4205857029 cites W2005244375 @default.
• W4205857029 cites W2011567980 @default.
• W4205857029 cites W2012034410 @default.
• W4205857029 cites W2016474243 @default.
• W4205857029 cites W2017560560 @default.
• W4205857029 cites W2018686666 @default.
• W4205857029 cites W2021129827 @default.
• W4205857029 cites W2024886564 @default.
• W4205857029 cites W2027035932 @default.
• W4205857029 cites W2029760928 @default.
• W4205857029 cites W2033784618 @default.
• W4205857029 cites W2034808493 @default.
• W4205857029 cites W2037854342 @default.
• W4205857029 cites W2049377859 @default.
• W4205857029 cites W2051793746 @default.
• W4205857029 cites W2052158229 @default.
• W4205857029 cites W2052483304 @default.
• W4205857029 cites W2053395772 @default.
• W4205857029 cites W2055482379 @default.
• W4205857029 cites W2055706903 @default.
• W4205857029 cites W2058352802 @default.
• W4205857029 cites W2062376206 @default.
• W4205857029 cites W2062989416 @default.
• W4205857029 cites W2078129137 @default.
• W4205857029 cites W2078635052 @default.
• W4205857029 cites W2084373725 @default.
• W4205857029 cites W2085519504 @default.
• W4205857029 cites W2090785462 @default.
• W4205857029 cites W2101033580 @default.
• W4205857029 cites W2103017472 @default.
• W4205857029 cites W2104989405 @default.
• W4205857029 cites W2107580398 @default.
• W4205857029 cites W2108493629 @default.
• W4205857029 cites W2108813933 @default.
• W4205857029 cites W2109613520 @default.
• W4205857029 cites W2114472373 @default.
• W4205857029 cites W2116791127 @default.
• W4205857029 cites W2118326567 @default.
• W4205857029 cites W2119025581 @default.
• W4205857029 cites W2119442255 @default.
• W4205857029 cites W2120784205 @default.
• W4205857029 cites W2121535080 @default.
• W4205857029 cites W2129124381 @default.
• W4205857029 cites W2132101917 @default.
• W4205857029 cites W2132739313 @default.
• W4205857029 cites W2134981162 @default.
• W4205857029 cites W2137799518 @default.
• W4205857029 cites W2138255346 @default.
• W4205857029 cites W2138654862 @default.
• W4205857029 cites W2146512944 @default.
• W4205857029 cites W2149642623 @default.
• W4205857029 cites W2164683872 @default.
• W4205857029 cites W2166059050 @default.
• W4205857029 cites W2173732482 @default.
• W4205857029 cites W2176679849 @default.
• W4205857029 cites W2187486383 @default.
• W4205857029 cites W2462540433 @default.
• W4205857029 cites W2537211012 @default.
• W4205857029 cites W2550287279 @default.
• W4205857029 cites W2592790525 @default.
• W4205857029 cites W2734384506 @default.
• W4205857029 cites W2736345178 @default.
• W4205857029 cites W2748826793 @default.
• W4205857029 cites W2757943674 @default.
• W4205857029 cites W2761933427 @default.
• W4205857029 cites W2767195935 @default.
• W4205857029 cites W2790959743 @default.
• W4205857029 cites W2792457831 @default.
• W4205857029 cites W2800449741 @default.

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