Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205873964> ?p ?o ?g. }
- W4205873964 endingPage "1431" @default.
- W4205873964 startingPage "1423" @default.
- W4205873964 abstract "Therapeutic drug monitoring (TDM) is useful for optimizing monoclonal antibodies (mAbs) for the treatment of immune-mediated inflammatory disorders including inflammatory bowel disease (IBD). However, TDM in clinical practice is still restricted by long turnaround times between sampling and results and the fact that dosing of mAbs to a target drug concentration is challenging due to high pharmacokinetic (PK) variability at both a population and patient level. Overcoming these barriers may be addressed by point-of-care (POC) assays, model-informed precision dosing (MIPD), and pharmacogenetics/pharmacogenomics.This review provides an overview of the optimization of TDM of mAbs in IBD including POC testing, MIPD, and pharmacogenetics.Recent advances in sampling, quantification, and support of clinical decisions include POC assays and PK dashboards, which may allow for prompt and precise application of TDM in clinical practice. Future perspectives toward a more personalized implementation of TDM could include the incorporation of pharmacogenetics/pharmacogenomics to identify subgroups of patients who would benefit more from proactive TDM or combination therapy such as those prone to immunogenicity and/or accelerated drug clearance. However, there are still challenges regarding the implementation of these innovative approaches, and more data from prospective studies and randomized controlled trials are needed." @default.
- W4205873964 created "2022-01-26" @default.
- W4205873964 creator A5060108766 @default.
- W4205873964 creator A5078196032 @default.
- W4205873964 date "2021-12-02" @default.
- W4205873964 modified "2023-09-25" @default.
- W4205873964 title "Optimizing therapeutic drug monitoring in inflammatory bowel disease: a focus on therapeutic monoclonal antibodies" @default.
- W4205873964 cites W1487398079 @default.
- W4205873964 cites W1976546496 @default.
- W4205873964 cites W2003835888 @default.
- W4205873964 cites W2008531871 @default.
- W4205873964 cites W2121816503 @default.
- W4205873964 cites W2149309054 @default.
- W4205873964 cites W2476548567 @default.
- W4205873964 cites W2479623580 @default.
- W4205873964 cites W2530995556 @default.
- W4205873964 cites W2599446307 @default.
- W4205873964 cites W2600807646 @default.
- W4205873964 cites W2606702770 @default.
- W4205873964 cites W2611555333 @default.
- W4205873964 cites W2748972541 @default.
- W4205873964 cites W2774965460 @default.
- W4205873964 cites W2790432738 @default.
- W4205873964 cites W2790920611 @default.
- W4205873964 cites W2791601614 @default.
- W4205873964 cites W2793288127 @default.
- W4205873964 cites W2795832935 @default.
- W4205873964 cites W2807107922 @default.
- W4205873964 cites W2807354012 @default.
- W4205873964 cites W2807752300 @default.
- W4205873964 cites W2885847499 @default.
- W4205873964 cites W2898464095 @default.
- W4205873964 cites W2903922961 @default.
- W4205873964 cites W2905446203 @default.
- W4205873964 cites W2908031613 @default.
- W4205873964 cites W2914225473 @default.
- W4205873964 cites W2916794721 @default.
- W4205873964 cites W2921300065 @default.
- W4205873964 cites W2923576761 @default.
- W4205873964 cites W2925936395 @default.
- W4205873964 cites W2944335283 @default.
- W4205873964 cites W2946766748 @default.
- W4205873964 cites W2947239898 @default.
- W4205873964 cites W2947682635 @default.
- W4205873964 cites W2949255324 @default.
- W4205873964 cites W2960185068 @default.
- W4205873964 cites W2961547340 @default.
- W4205873964 cites W2962783208 @default.
- W4205873964 cites W2970941662 @default.
- W4205873964 cites W2978824500 @default.
- W4205873964 cites W2978880955 @default.
- W4205873964 cites W2980187728 @default.
- W4205873964 cites W2981369898 @default.
- W4205873964 cites W2981379845 @default.
- W4205873964 cites W2982347425 @default.
- W4205873964 cites W2982350957 @default.
- W4205873964 cites W3002318915 @default.
- W4205873964 cites W3003100238 @default.
- W4205873964 cites W3004803806 @default.
- W4205873964 cites W3009333022 @default.
- W4205873964 cites W3018394618 @default.
- W4205873964 cites W3021307263 @default.
- W4205873964 cites W3022411707 @default.
- W4205873964 cites W3025703135 @default.
- W4205873964 cites W3026522548 @default.
- W4205873964 cites W3031220816 @default.
- W4205873964 cites W3031486532 @default.
- W4205873964 cites W3033999832 @default.
- W4205873964 cites W3049054729 @default.
- W4205873964 cites W3081181261 @default.
- W4205873964 cites W3094948559 @default.
- W4205873964 cites W3097186514 @default.
- W4205873964 cites W3100112673 @default.
- W4205873964 cites W3107522317 @default.
- W4205873964 cites W3111210633 @default.
- W4205873964 cites W3113400896 @default.
- W4205873964 cites W3129156881 @default.
- W4205873964 cites W3131841634 @default.
- W4205873964 cites W3135273470 @default.
- W4205873964 cites W3138562990 @default.
- W4205873964 cites W3163390188 @default.
- W4205873964 cites W3168623818 @default.
- W4205873964 cites W3169178469 @default.
- W4205873964 cites W3170455294 @default.
- W4205873964 cites W3175704805 @default.
- W4205873964 cites W3186840737 @default.
- W4205873964 cites W3190385737 @default.
- W4205873964 cites W3190445083 @default.
- W4205873964 cites W3194433942 @default.
- W4205873964 cites W3196878046 @default.
- W4205873964 cites W3199247301 @default.
- W4205873964 cites W3200938257 @default.
- W4205873964 cites W3204717716 @default.
- W4205873964 cites W3214217810 @default.
- W4205873964 cites W4221125055 @default.
- W4205873964 cites W4225558860 @default.
- W4205873964 doi "https://doi.org/10.1080/17425255.2021.2027367" @default.
- W4205873964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34996330" @default.