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• W4205884092 abstract "In a phase 3 trial in African infants and children, the RTS,S/AS01 vaccine (GSK) showed moderate efficacy against clinical malaria. We sought to further understand RTS,S/AS01-induced immune responses associated with vaccine protection.Applying the blood transcriptional module (BTM) framework, we characterized the transcriptomic response to RTS,S/AS01 vaccination in antigen-stimulated (and vehicle control) peripheral blood mononuclear cells sampled from a subset of trial participants at baseline and month 3 (1-month post-third dose). Using a matched case-control study design, we evaluated which of these 'RTS,S/AS01 signature BTMs' associated with malaria case status in RTS,S/AS01 vaccinees. Antigen-specific T-cell responses were analyzed by flow cytometry. We also performed a cross-study correlates analysis where we assessed the generalizability of our findings across three controlled human malaria infection studies of healthy, malaria-naive adult RTS,S/AS01 recipients.RTS,S/AS01 vaccination was associated with downregulation of B-cell and monocyte-related BTMs and upregulation of T-cell-related BTMs, as well as higher month 3 (vs. baseline) circumsporozoite protein-specific CD4+ T-cell responses. There were few RTS,S/AS01-associated BTMs whose month 3 levels correlated with malaria risk. In contrast, baseline levels of BTMs associated with dendritic cells and with monocytes (among others) correlated with malaria risk. The baseline dendritic cell- and monocyte-related BTM correlations with malaria risk appeared to generalize to healthy, malaria-naive adults.A prevaccination transcriptomic signature associates with malaria in RTS,S/AS01-vaccinated African children, and elements of this signature may be broadly generalizable. The consistent presence of monocyte-related modules suggests that certain monocyte subsets may inhibit protective RTS,S/AS01-induced responses.Funding was obtained from the NIH-NIAID (R01AI095789), NIH-NIAID (U19AI128914), PATH Malaria Vaccine Initiative (MVI), and Ministerio de Economía y Competitividad (Instituto de Salud Carlos III, PI11/00423 and PI14/01422). The RNA-seq project has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under grant number U19AI110818 to the Broad Institute. This study was also supported by the Vaccine Statistical Support (Bill and Melinda Gates Foundation award INV-008576/OPP1154739 to R.G.). C.D. was the recipient of a Ramon y Cajal Contract from the Ministerio de Economía y Competitividad (RYC-2008-02631). G.M. was the recipient of a Sara Borrell-ISCIII fellowship (CD010/00156) and work was performed with the support of Department of Health, Catalan Government grant (SLT006/17/00109). This research is part of the ISGlobal's Program on the Molecular Mechanisms of Malaria which is partially supported by the Fundación Ramón Areces and we acknowledge support from the Spanish Ministry of Science and Innovation through the 'Centro de Excelencia Severo Ochoa 2019-2023' Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program." @default.
• W4205884092 created "2022-01-26" @default.
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• W4205884092 date "2022-01-21" @default.
• W4205884092 modified "2023-10-17" @default.
• W4205884092 title "Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case–control study" @default.
• W4205884092 cites W1242484266 @default.
• W4205884092 cites W1528421226 @default.
• W4205884092 cites W1607536760 @default.
• W4205884092 cites W1860505696 @default.
• W4205884092 cites W1904333788 @default.
• W4205884092 cites W1965060637 @default.
• W4205884092 cites W1969218538 @default.
• W4205884092 cites W1974769731 @default.
• W4205884092 cites W1986071019 @default.
• W4205884092 cites W2017445000 @default.
• W4205884092 cites W2034088837 @default.
• W4205884092 cites W2048134603 @default.
• W4205884092 cites W2049580315 @default.
• W4205884092 cites W2063627505 @default.
• W4205884092 cites W2081098333 @default.
• W4205884092 cites W2107018762 @default.
• W4205884092 cites W2108476551 @default.
• W4205884092 cites W2109106997 @default.
• W4205884092 cites W2110065044 @default.
• W4205884092 cites W2112220625 @default.
• W4205884092 cites W2123577868 @default.
• W4205884092 cites W2130410032 @default.
• W4205884092 cites W2137526110 @default.
• W4205884092 cites W2143421242 @default.
• W4205884092 cites W2146512944 @default.
• W4205884092 cites W2151777859 @default.
• W4205884092 cites W2158614517 @default.
• W4205884092 cites W2160395304 @default.
• W4205884092 cites W2163861382 @default.
• W4205884092 cites W2164643779 @default.
• W4205884092 cites W2172958821 @default.
• W4205884092 cites W2178883502 @default.
• W4205884092 cites W2181213627 @default.
• W4205884092 cites W2229921221 @default.
• W4205884092 cites W2233660390 @default.
• W4205884092 cites W2244674613 @default.
• W4205884092 cites W2340217599 @default.
• W4205884092 cites W2414241210 @default.
• W4205884092 cites W2436449558 @default.
• W4205884092 cites W2482786872 @default.
• W4205884092 cites W2545036041 @default.
• W4205884092 cites W2588086300 @default.
• W4205884092 cites W2612498490 @default.
• W4205884092 cites W2612894522 @default.
• W4205884092 cites W2613306892 @default.
• W4205884092 cites W2748324962 @default.
• W4205884092 cites W2760237399 @default.
• W4205884092 cites W2790844064 @default.
• W4205884092 cites W2898154893 @default.
• W4205884092 cites W2901618591 @default.
• W4205884092 cites W2910016806 @default.
• W4205884092 cites W2946248791 @default.
• W4205884092 cites W2968184509 @default.
• W4205884092 cites W2969548103 @default.
• W4205884092 cites W3005530564 @default.
• W4205884092 cites W3007282081 @default.
• W4205884092 cites W3013397538 @default.
• W4205884092 cites W3015851459 @default.
• W4205884092 cites W3017483958 @default.
• W4205884092 cites W3021855507 @default.
• W4205884092 cites W3024426664 @default.
• W4205884092 cites W3044993434 @default.
• W4205884092 cites W3115162871 @default.
• W4205884092 cites W3126460810 @default.
• W4205884092 cites W3139502687 @default.
• W4205884092 cites W3160449471 @default.
• W4205884092 cites W3166615618 @default.
• W4205884092 cites W4254848468 @default.

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