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- W4205887306 abstract "Despite effective chemotherapy to treat schistosome infections, re-infection rates are extremely high. Resistance to reinfection can develop, however it typically takes several years following numerous rounds of treatment and re-infection, and often develops in only a small cohort of individuals. Using a well-established and highly permissive mouse model, we investigated whether immunoregulatory mechanisms influence the development of resistance. Following Praziquantel (PZQ) treatment of S. mansoni infected mice we observed a significant and mixed anti-worm response, characterized by Th1, Th2 and Th17 responses. Despite the elevated anti-worm response in PBMC's, liver, spleen and mesenteric lymph nodes, this did not confer any protection from a secondary challenge infection. Because a significant increase in IL-10-producing CD4(+)CD44(+)CD25(+)GITR(+) lymphocytes was observed, we hypothesised that IL-10 was obstructing the development of resistance. Blockade of IL-10 combined with PZQ treatment afforded a greater than 50% reduction in parasite establishment during reinfection, compared to PZQ treatment alone, indicating that IL-10 obstructs the development of acquired resistance. Markedly enhanced Th1, Th2 and Th17 responses, worm-specific IgG1, IgG2b and IgE and circulating eosinophils characterized the protection. This study demonstrates that blocking IL-10 signalling during PZQ treatment can facilitate the development of protective immunity and provide a highly effective strategy to protect against reinfection with S. mansoni. PMID: 21829367 Funding information This work was supported by: Intramural NIH HHS, United States Medical Research Council, United Kingdom Grant ID: MC_UP_A253_1028" @default.
- W4205887306 created "2022-01-26" @default.
- W4205887306 creator A5076715795 @default.
- W4205887306 date "2011-08-16" @default.
- W4205887306 modified "2023-10-05" @default.
- W4205887306 title "Faculty Opinions recommendation of IL-10 blocks the development of resistance to re-infection with Schistosoma mansoni." @default.
- W4205887306 doi "https://doi.org/10.3410/f.12774956.14048054" @default.
- W4205887306 hasPublicationYear "2011" @default.
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