Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205890231> ?p ?o ?g. }
- W4205890231 endingPage "381" @default.
- W4205890231 startingPage "363" @default.
- W4205890231 abstract "The senescence of brain cells has recently attracted great interest regarding its potentially important role in brain aging and neurodegenerative diseases such as Alzheimer and Parkinson diseases. From physiological aging to neurodegeneration, senescencelike phenotypes are found in multiple subclasses of dividing and nondividing brain cells, including glial cells, endothelial cells, neural stem cells, and neurons. These senescent cells may co-opt cellular machineries to activate their secretosomes, contributing to neuroinflammatory lesions and focal atrophies. Thus, antisenescence therapies may provide a unique opportunity to attenuate a wide range of age-related neuropathology. However, questions exist about which cell compartments are more relevant for pathogenesis and whether mitotic and postmitotic activities of senescent cells are characteristically distinct. The two types of senescence may contribute distinctively to neurodegeneration, and their senescence and secretory pathways may respond differently to genetic and pharmacological perturbations, known as senolytics or senomorphics. A better understanding of the mechanisms underlying the heterogeneity of senescence will help the development of novel therapeutic strategies for neurodegenerative diseases." @default.
- W4205890231 created "2022-01-26" @default.
- W4205890231 creator A5042213683 @default.
- W4205890231 creator A5088088646 @default.
- W4205890231 date "2022-01-01" @default.
- W4205890231 modified "2023-09-27" @default.
- W4205890231 title "Cellular senescence in neurodegenerative diseases" @default.
- W4205890231 cites W1033197108 @default.
- W4205890231 cites W1544991924 @default.
- W4205890231 cites W1552543129 @default.
- W4205890231 cites W1565351177 @default.
- W4205890231 cites W1604647569 @default.
- W4205890231 cites W1800944583 @default.
- W4205890231 cites W1808133217 @default.
- W4205890231 cites W1811802061 @default.
- W4205890231 cites W1861300743 @default.
- W4205890231 cites W1940501747 @default.
- W4205890231 cites W1967331757 @default.
- W4205890231 cites W1976635482 @default.
- W4205890231 cites W1980729492 @default.
- W4205890231 cites W1981000616 @default.
- W4205890231 cites W1982481909 @default.
- W4205890231 cites W1989958428 @default.
- W4205890231 cites W1991625887 @default.
- W4205890231 cites W1992182416 @default.
- W4205890231 cites W2001720505 @default.
- W4205890231 cites W2003634461 @default.
- W4205890231 cites W2004314923 @default.
- W4205890231 cites W2007632818 @default.
- W4205890231 cites W2016802225 @default.
- W4205890231 cites W2017042997 @default.
- W4205890231 cites W2025693096 @default.
- W4205890231 cites W2026433865 @default.
- W4205890231 cites W2028169108 @default.
- W4205890231 cites W2061248667 @default.
- W4205890231 cites W2064810608 @default.
- W4205890231 cites W2069519394 @default.
- W4205890231 cites W2071251338 @default.
- W4205890231 cites W2077450385 @default.
- W4205890231 cites W2079302588 @default.
- W4205890231 cites W2084792449 @default.
- W4205890231 cites W2086540565 @default.
- W4205890231 cites W2087404852 @default.
- W4205890231 cites W2090067193 @default.
- W4205890231 cites W2096347759 @default.
- W4205890231 cites W2097049162 @default.
- W4205890231 cites W2116505693 @default.
- W4205890231 cites W2125084281 @default.
- W4205890231 cites W2128807350 @default.
- W4205890231 cites W2130458932 @default.
- W4205890231 cites W2139976280 @default.
- W4205890231 cites W2140930678 @default.
- W4205890231 cites W2150336691 @default.
- W4205890231 cites W2154462305 @default.
- W4205890231 cites W2160279897 @default.
- W4205890231 cites W2210634983 @default.
- W4205890231 cites W2224886002 @default.
- W4205890231 cites W2264758825 @default.
- W4205890231 cites W2295308497 @default.
- W4205890231 cites W2407603317 @default.
- W4205890231 cites W2510083852 @default.
- W4205890231 cites W2534906898 @default.
- W4205890231 cites W2583634043 @default.
- W4205890231 cites W2591114726 @default.
- W4205890231 cites W2750509325 @default.
- W4205890231 cites W2762611634 @default.
- W4205890231 cites W2782415604 @default.
- W4205890231 cites W2784612915 @default.
- W4205890231 cites W2801266108 @default.
- W4205890231 cites W2802493769 @default.
- W4205890231 cites W2805598377 @default.
- W4205890231 cites W2860743873 @default.
- W4205890231 cites W2888559669 @default.
- W4205890231 cites W2890865075 @default.
- W4205890231 cites W2897278865 @default.
- W4205890231 cites W2905659301 @default.
- W4205890231 cites W2908142980 @default.
- W4205890231 cites W2912225074 @default.
- W4205890231 cites W2912918280 @default.
- W4205890231 cites W2915779410 @default.
- W4205890231 cites W2923125845 @default.
- W4205890231 cites W2928157366 @default.
- W4205890231 cites W2942678593 @default.
- W4205890231 cites W2948410583 @default.
- W4205890231 cites W2954373828 @default.
- W4205890231 cites W2970747205 @default.
- W4205890231 cites W2977336849 @default.
- W4205890231 cites W2982456513 @default.
- W4205890231 cites W2989654235 @default.
- W4205890231 cites W2990274291 @default.
- W4205890231 cites W2991414673 @default.
- W4205890231 cites W3002036216 @default.
- W4205890231 cites W3028992072 @default.
- W4205890231 cites W3111207111 @default.
- W4205890231 cites W3120886928 @default.
- W4205890231 cites W3124591628 @default.
- W4205890231 cites W4211139529 @default.
- W4205890231 doi "https://doi.org/10.1016/b978-0-12-822514-1.00012-2" @default.