FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205893590> ?p ?o ?g. }

• W4205893590 endingPage "12" @default.
• W4205893590 startingPage "1" @default.
• W4205893590 abstract "Hepatitis B virus-related acute liver failure (HBV-ALF) is a common type of liver failure, associated with high short-term mortality and morbidity rates. However, the immune landscape of HBV-ALF and its correlation with cell death are currently unknown. Based on 3 Gene Expression Omnibus data sets, infiltrated immune cells were quantified by single-sample gene set enrichment analysis method. The expression levels of immune genes and the abundance of immune cells in liver failure were compared with those in normal liver. The enrichment scores of cell death gene sets from Kyoto Encyclopedia of Genes and Genomes (KEGG) were calculated by gene set variation analysis method, and a protein-protein interaction (PPI) network was constructed using Cytoscape. Besides 21 differentially expressed immune genes, we identified 11 types of differentially infiltrated immune cells in HBV-ALF compared with normal liver. Enriched pathways of these immune genes mainly consisted of chemokine receptors, chemokine binding, interleukin-10 signaling, and TNFs bind their physiological receptors by Reactome pathway analysis. In addition, the enrichment scores of apoptosis and necroptosis pathway instead of autophagy and ferroptosis were increased in liver failure compared with normal liver. PPI network and gene cluster analysis of immune genes and apoptosis and necroptosis genes suggested that hub genes were mainly related to immune response and apoptosis. In summary, our study offers a conceptual framework to understand the immune landscape of HBV-ALF, which might help to improve prognosis." @default.
• W4205893590 created "2022-01-26" @default.
• W4205893590 creator A5008182583 @default.
• W4205893590 creator A5029696011 @default.
• W4205893590 creator A5039778506 @default.
• W4205893590 creator A5058568961 @default.
• W4205893590 creator A5059323250 @default.
• W4205893590 creator A5072071140 @default.
• W4205893590 creator A5080179476 @default.
• W4205893590 creator A5081201228 @default.
• W4205893590 creator A5081688615 @default.
• W4205893590 creator A5090688671 @default.
• W4205893590 date "2022-01-06" @default.
• W4205893590 modified "2023-10-17" @default.
• W4205893590 title "The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration Analysis" @default.
• W4205893590 cites W2010475904 @default.
• W4205893590 cites W2033587318 @default.
• W4205893590 cites W2074213282 @default.
• W4205893590 cites W2081088350 @default.
• W4205893590 cites W2118844439 @default.
• W4205893590 cites W2142225943 @default.
• W4205893590 cites W2159616534 @default.
• W4205893590 cites W2170866962 @default.
• W4205893590 cites W2327856202 @default.
• W4205893590 cites W2757195376 @default.
• W4205893590 cites W2890318255 @default.
• W4205893590 cites W2894095552 @default.
• W4205893590 cites W2901004936 @default.
• W4205893590 cites W2937441321 @default.
• W4205893590 cites W2948105638 @default.
• W4205893590 cites W2949273159 @default.
• W4205893590 cites W2969017711 @default.
• W4205893590 cites W2971079908 @default.
• W4205893590 cites W2972923507 @default.
• W4205893590 cites W2973083853 @default.
• W4205893590 cites W2999044683 @default.
• W4205893590 cites W3014881093 @default.
• W4205893590 cites W3026170167 @default.
• W4205893590 cites W3042336587 @default.
• W4205893590 cites W4235551585 @default.
• W4205893590 cites W4242966060 @default.
• W4205893590 doi "https://doi.org/10.1155/2022/6764379" @default.
• W4205893590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35036448" @default.
• W4205893590 hasPublicationYear "2022" @default.
• W4205893590 type Work @default.
• W4205893590 citedByCount "4" @default.
• W4205893590 countsByYear W42058935902022 @default.
• W4205893590 countsByYear W42058935902023 @default.
• W4205893590 crossrefType "journal-article" @default.
• W4205893590 hasAuthorship W4205893590A5008182583 @default.
• W4205893590 hasAuthorship W4205893590A5029696011 @default.
• W4205893590 hasAuthorship W4205893590A5039778506 @default.
• W4205893590 hasAuthorship W4205893590A5058568961 @default.
• W4205893590 hasAuthorship W4205893590A5059323250 @default.
• W4205893590 hasAuthorship W4205893590A5072071140 @default.
• W4205893590 hasAuthorship W4205893590A5080179476 @default.
• W4205893590 hasAuthorship W4205893590A5081201228 @default.
• W4205893590 hasAuthorship W4205893590A5081688615 @default.
• W4205893590 hasAuthorship W4205893590A5090688671 @default.
• W4205893590 hasBestOaLocation W42058935901 @default.
• W4205893590 hasConcept C103474210 @default.
• W4205893590 hasConcept C104317684 @default.
• W4205893590 hasConcept C13373296 @default.
• W4205893590 hasConcept C150194340 @default.
• W4205893590 hasConcept C152724338 @default.
• W4205893590 hasConcept C157081693 @default.
• W4205893590 hasConcept C162317418 @default.
• W4205893590 hasConcept C190283241 @default.
• W4205893590 hasConcept C203014093 @default.
• W4205893590 hasConcept C2522874641 @default.
• W4205893590 hasConcept C2780593183 @default.
• W4205893590 hasConcept C31573885 @default.
• W4205893590 hasConcept C54355233 @default.
• W4205893590 hasConcept C86803240 @default.
• W4205893590 hasConcept C8891405 @default.
• W4205893590 hasConcept C94030615 @default.
• W4205893590 hasConceptScore W4205893590C103474210 @default.
• W4205893590 hasConceptScore W4205893590C104317684 @default.
• W4205893590 hasConceptScore W4205893590C13373296 @default.
• W4205893590 hasConceptScore W4205893590C150194340 @default.
• W4205893590 hasConceptScore W4205893590C152724338 @default.
• W4205893590 hasConceptScore W4205893590C157081693 @default.
• W4205893590 hasConceptScore W4205893590C162317418 @default.
• W4205893590 hasConceptScore W4205893590C190283241 @default.
• W4205893590 hasConceptScore W4205893590C203014093 @default.
• W4205893590 hasConceptScore W4205893590C2522874641 @default.
• W4205893590 hasConceptScore W4205893590C2780593183 @default.
• W4205893590 hasConceptScore W4205893590C31573885 @default.
• W4205893590 hasConceptScore W4205893590C54355233 @default.
• W4205893590 hasConceptScore W4205893590C86803240 @default.
• W4205893590 hasConceptScore W4205893590C8891405 @default.
• W4205893590 hasConceptScore W4205893590C94030615 @default.
• W4205893590 hasFunder F4320321001 @default.
• W4205893590 hasLocation W42058935901 @default.
• W4205893590 hasLocation W42058935902 @default.
• W4205893590 hasLocation W42058935903 @default.
• W4205893590 hasLocation W42058935904 @default.
• W4205893590 hasOpenAccess W4205893590 @default.

• next