Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205915545> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4205915545 endingPage "285" @default.
- W4205915545 startingPage "282" @default.
- W4205915545 abstract "Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disorder resulting from a reciprocal translocation between the long arms of chromosomes 9 and 22. This is termed the Philadelphia chromosome, and leads to production of the fusion oncoprotein BCR-ABL, a 210 kDa constitutively active tyrosine kinase. CML has three distinct phases: chronic, accelerated and blast. Most patients (85%) present in the chronic phase, which is associated with leucocytosis and splenomegaly. More advanced phases are associated with bone marrow failure and carry a poor prognosis. The introduction of tyrosine kinase inhibitors (TKIs; imatinib, dasatinib, nilotinib, bosutinib, ponatinib) has altered the clinical course of CML for most patients, turning it from a fatal leukaemia to a chronic disorder managed with oral medication. Patients with chronic phase CML have excellent responses to TKIs, and individuals with an optimal response can expect a normal lifespan; some successfully discontinue TKI therapy. However, resistance to TKIs is seen, particularly in advanced CML. In these patients, allogeneic stem cell transplantation can warrant consideration. With increasing experience in TKI use, different adverse effect profiles are emerging and require consideration when choosing the most suitable TKI for an individual patient." @default.
- W4205915545 created "2022-01-26" @default.
- W4205915545 creator A5057534414 @default.
- W4205915545 date "2021-05-01" @default.
- W4205915545 modified "2023-09-26" @default.
- W4205915545 title "Chronic myeloid leukaemia" @default.
- W4205915545 cites W2107398329 @default.
- W4205915545 cites W2343511371 @default.
- W4205915545 cites W2780178948 @default.
- W4205915545 cites W3009751715 @default.
- W4205915545 cites W3046714659 @default.
- W4205915545 doi "https://doi.org/10.1016/j.mpmed.2021.02.005" @default.
- W4205915545 hasPublicationYear "2021" @default.
- W4205915545 type Work @default.
- W4205915545 citedByCount "1" @default.
- W4205915545 countsByYear W42059155452022 @default.
- W4205915545 crossrefType "journal-article" @default.
- W4205915545 hasAuthorship W4205915545A5057534414 @default.
- W4205915545 hasConcept C104317684 @default.
- W4205915545 hasConcept C121608353 @default.
- W4205915545 hasConcept C126322002 @default.
- W4205915545 hasConcept C138626823 @default.
- W4205915545 hasConcept C143998085 @default.
- W4205915545 hasConcept C170493617 @default.
- W4205915545 hasConcept C185592680 @default.
- W4205915545 hasConcept C203014093 @default.
- W4205915545 hasConcept C2777413986 @default.
- W4205915545 hasConcept C2777583451 @default.
- W4205915545 hasConcept C2778208673 @default.
- W4205915545 hasConcept C2778729363 @default.
- W4205915545 hasConcept C2778820342 @default.
- W4205915545 hasConcept C2778904597 @default.
- W4205915545 hasConcept C2779536868 @default.
- W4205915545 hasConcept C2780381907 @default.
- W4205915545 hasConcept C2910157418 @default.
- W4205915545 hasConcept C2993416501 @default.
- W4205915545 hasConcept C3019892230 @default.
- W4205915545 hasConcept C42362537 @default.
- W4205915545 hasConcept C55493867 @default.
- W4205915545 hasConcept C71924100 @default.
- W4205915545 hasConceptScore W4205915545C104317684 @default.
- W4205915545 hasConceptScore W4205915545C121608353 @default.
- W4205915545 hasConceptScore W4205915545C126322002 @default.
- W4205915545 hasConceptScore W4205915545C138626823 @default.
- W4205915545 hasConceptScore W4205915545C143998085 @default.
- W4205915545 hasConceptScore W4205915545C170493617 @default.
- W4205915545 hasConceptScore W4205915545C185592680 @default.
- W4205915545 hasConceptScore W4205915545C203014093 @default.
- W4205915545 hasConceptScore W4205915545C2777413986 @default.
- W4205915545 hasConceptScore W4205915545C2777583451 @default.
- W4205915545 hasConceptScore W4205915545C2778208673 @default.
- W4205915545 hasConceptScore W4205915545C2778729363 @default.
- W4205915545 hasConceptScore W4205915545C2778820342 @default.
- W4205915545 hasConceptScore W4205915545C2778904597 @default.
- W4205915545 hasConceptScore W4205915545C2779536868 @default.
- W4205915545 hasConceptScore W4205915545C2780381907 @default.
- W4205915545 hasConceptScore W4205915545C2910157418 @default.
- W4205915545 hasConceptScore W4205915545C2993416501 @default.
- W4205915545 hasConceptScore W4205915545C3019892230 @default.
- W4205915545 hasConceptScore W4205915545C42362537 @default.
- W4205915545 hasConceptScore W4205915545C55493867 @default.
- W4205915545 hasConceptScore W4205915545C71924100 @default.
- W4205915545 hasIssue "5" @default.
- W4205915545 hasLocation W42059155451 @default.
- W4205915545 hasOpenAccess W4205915545 @default.
- W4205915545 hasPrimaryLocation W42059155451 @default.
- W4205915545 hasRelatedWork W1554937972 @default.
- W4205915545 hasRelatedWork W2013963600 @default.
- W4205915545 hasRelatedWork W2155107050 @default.
- W4205915545 hasRelatedWork W2599004336 @default.
- W4205915545 hasRelatedWork W2606453016 @default.
- W4205915545 hasRelatedWork W2943053710 @default.
- W4205915545 hasRelatedWork W388027184 @default.
- W4205915545 hasRelatedWork W4205915545 @default.
- W4205915545 hasRelatedWork W4296468420 @default.
- W4205915545 hasRelatedWork W4363673819 @default.
- W4205915545 hasVolume "49" @default.
- W4205915545 isParatext "false" @default.
- W4205915545 isRetracted "false" @default.
- W4205915545 workType "article" @default.