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- W4205954714 abstract "The role of radiation therapy in the management of high-grade gliomas was established by a series of prospective randomized trials. Subsequently, numerous attempts to improve outcomes with dose escalation, radiation sensitizers, neutrons, and brachytherapy have been unsuccessful. The lack of success with these approaches may be a consequence of poor target volume definition, tumor repopulation, or innate radioresistance. Until recently, the role of chemotherapy in the management of glioblastoma multiforme was unclear, but a large phase III randomized trial conclusively demonstrated a survival advantage of temozolomide delivered concurrently with radiation and in the adjuvant setting. The role of chemotherapy in the management of anaplastic astrocytoma and anaplastic oliodendroglioma remains to be defined. Current focus is on the identification of molecular pathways unique to high-grade gliomas that may serve as targets for future therapeutic agents." @default.
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- W4205954714 date "2007-11-20" @default.
- W4205954714 modified "2023-09-27" @default.
- W4205954714 title "Radiation Therapy" @default.
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- W4205954714 doi "https://doi.org/10.1007/978-1-59745-185-7_13" @default.
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